Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020672 (
hypothermia
)
17,327
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of
Dopram
(R) on hexobarbital induced narcosis and
hypothermia
was determined. Sodium hexobarbital (70mg/kg, i.p.) sleeping times were assessed in saline,
Dopram
(R), 20 and 40 mg/kg, i.p., administered mice. A dose-response increase in sodium hexobarbital induced narcosis was produced by
Dopram
(R). The duration of
Dopram
(R) effect on hexobarbital narcosis was also assessed.
Dopram
(R) potentiated significantly hexobarbital sleeping times when administered two hours prior to sodium hexobarbital challenge.
Dopram
(R) also was observed to significantly increase the hypothermic response to hexobarbital. The effect of the individual components of
Dopram
(R) (doxapram hydrochloride and chlorobutanol) on hexobarbital narcosis and
hypothermia
was evaluated. It was found that doxapram hydrochloride (20 and 40 mg/kg, i.p.) and chlorobutanol (5 and 10 mg/kg, i.p.) potentiated sodium hexobarbital narcosis and
hypothermia
. It seems that doxapram hydrochloride and chlorobutanol are both responsible for the potentiation of hexobarbital narcosis and
hypothermia
by
Dopram
(R).
...
PMID:Evaluation of Dopram(R) and its effects on hexobarbital narcosis. 69 25
