Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ergometrine (EGM), 40 mg/kg ip or 100 microgram ivc, produces strong and long-lasting increase of locomotor activity of the rat, completely prevented by pretreatment with spiperone, 0.4 mg/kg, ip, or pimozide, 4 mg/kg ip. Given at a dose of 100 microgram ivc EGM produced a deep hypothermia, resistant to spiperone pretreatment (0.4 mg/kg ip). EGM decelerates cerebral serotonin (5-HT) turnover in mice and rats as measured by accumulation of 5-hydroxyindoleacetic acid after pretreatment with probenecid, and depresses the accumulation of 5-HT in the rat brain stem after pretreatment with pargyline. EGM potentiates the hind limb flexor of spinal rat. This effect is blocked by cyproheptadine (1 mg/kg ip) and danitracen (3 mg/kg ip). The results indicate that EGM stimulates both dopamine and 5-HT receptors in the central nervous system.
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PMID:Dopaminergic and serotonergic effects of ergometrine. 88 3

Ergometrine, a spasmolytic which also stimulates dopamine receptors, was investigated as a potential central stimulant. It did not influence the locomotor activity of normal rats and mice, and in high doses even depressed it. The locomotor activity depressed by reserpine, spiroperidol, and pimozide was elevated by ergometrine. Ergometrine antagonized neuroleptic-induced catalepsy and abolished ptosis and hypothermia produced by reserpine. Given alone ergometrine depressed the body temperature in rats and mice, and this effect was abolished by pimozide in both species, and by spiroperidol and haloperidol in mice. The hypothermia was not antagonized by atropine. In several respects the central action of ergometrine resembles that of apomorphine.
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PMID:Central action of ergometrine. 103 20