Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sodium salt of 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid inhibits exploratory behavior and induces hypothermia in mice. The compound enhances central effects of L-DOPA, such as: gross excitation in group, fighting behavior, anticataleptogenic action and hyperthermic effect. The L-DOPA central effects are mitigated by pyridoxal phosphate. The 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid sodium salt abolishes the protective action of pyridoxal phosphate. In vitro this salt inhibits DOPA-decarboxylase. It is suggested that the compound under discussion is a competitive antagonist of L-DOPA, when the latter is involved in reactions with pyridoxal phosphate.
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PMID:[The pharmacology of 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid sodium salt]. 56 75

A mild hypothermia was produced in female rats during treatment with pyridoxine HCl (Vitamin B6), 100 mg/kg, administered in the drinking water. The hypothermic effect appeared by day 3 and persisted through 15 days of treatment. The reduction in core temperature was greater early in the day, just following the nocturnal period of maximum food and water consumption of the rat. Tail tendon temperatures of control and pyridoxine-treated animals showed no evidence of increased heat loss. Thus the hypothermia appears to reflect decreased heat production. The implications of a reduced metabolic rate for gerontological research are discussed.
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PMID:Pyridoxine reduces core body temperature in rats. 707 Oct 86