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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The intraperitoneal administration of sodium salicylate, L-tryptophan, and tyrosine resulted in significant hypothermia when rats were exposed to a 4degree C ambient temperature. Salicylate and tryptophan increased plasma levels of nonprotein-bound tryptophan while total and bound tryptophan were reduced in salicylate-treated rats. Tryptophan concentrations were unaffected by tyrosine administration. Concomitant with increases in free plasma tryptophan, there occurred significant rises in brain levels of tryptophan in both groups of rats, while brain tyrosine levels were increased in those rats receiving tyrosine. Similarly, significant increments in hypothalamic serotonin levels in rats receiving salicylate or L-tryptophan and increases in hypothalamic norepinephrine in tyrosine-treated rats seem to reflect the increased availability of tryptophan and tyrosine for monamine synthesis. However, alternative mechanisms of hypothermiaseem to be operative since oxygen consumption studies demonstrate dissimilar results for tryptophan and salicylate administration.
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PMID:Salicylate, tryptophan, and tyrosine hypothermia. 113 May 45

The effects on body temperature of intracerebroventricular and intraperitoneal sodium salicylate were evaluated in anesthetized and nonanesthetized, nonrestrained rats. Also, the effects of various neurotransmitter receptor blocking drugs were evaluated on salicylate-induced hypothermia of nonanesthetized animals. Sodium salicylate, 150-350 mg/kg induced a dose-related hypothermia of unanesthetized animals. However, in anesthetized animals, marked hyperthermia was observed. In unanesthetized, unrestrained rats, intracerebroventricular administration of 1.0 mg/h salicylate caused greater hypothermia than peripheral administration of salicylate, 350 mg/kg. Salicylate hypothermia was unaffected by para-chlorophenylalanine, cyproheptadine, or naloxone, and was only partially inhibited by pimozide. These results strongly suggest a potent direct action of salicylate within the central nervous system to induce hypothermia, and suggest possible involvement of dopaminergic neurons in this process.
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PMID:Central and peripheral actions of salicylate in altering nonpyrogenic thermoregulation of rats. 288 3