Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

After the skin damage against the background of general deep prolonged hypothermia its organotypic regeneration took place with de novo formation of hairs and sebaceous glands. In certain periods of the wound process, the mitotic activity of keratinocytes was markedly higher than the rate of their apoptosis, thus providing for sharp thickening of the regenerating epidermis. No such phenomena were observed in the rats that were wounded under the normal thermal conditions. Instead a scar was formed in the place of regenerate. Accumulation of keratohyalin in granules in the epidermis granular layer and formation of a horny layer in the normothermic animals started earlier than in the cooled rats. Delay of differentiation of the keratinocytes, as well as marked predominance of the mitotic activity over the apoptosis rate in the regenerating epidermis of the cooled rats could induce organotypic skin regeneration.
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PMID:[Epidermal keratinocyte proliferation, differentiation and apoptosis in the posttraumatic skin regeneration of rats with different initial reactivities]. 770 82

The cytoprotective activity of F16BP has been documented in severe conditions such as convulsions, reperfusion injury, septic shock, diabetic complications, hypothermia-induced injury, UV-provoked skin damage and in other processes including apoptosis and excitotoxicity. F16BP shows very efficient cytoprotective activity in astroglial cells exposed to H(2)O(2)-provoked oxidative stress and during neuronal injury caused by hypoxic conditions. As most of the aforementioned processes involve iron activity-related conditions, we investigated the ferric and ferrous iron binding properties of F16BP under physiological conditions using (31)P NMR and EPR spectroscopy. Our results indicate that cytoprotective F16BP activity is predominantly based on ferrous iron sequestration. (31)P NMR spectroscopy of F16BP employing paramagnetic properties of iron clearly showed that F16BP forms stabile complexes with Fe(2+) which was verified by EPR of another divalent cation-Mn(2+). On the other hand, F16BP does not sequester ferric iron nor does it increase its redox activity as shown by (31)P NMR and EPR spin-trapping. Therefore, F16BP may be beneficial in neurodegenerative and other conditions that are characterised by ferric iron stores and deposits.
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PMID:Relevance of the ability of fructose 1,6-bis(phosphate) to sequester ferrous but not ferric ions. 2123 35