Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Administration of 10 mg/kg TRH to mice was found to reduce the sleep and hypothermia induced by 4.7 g/kg ethanol. However, TRH did not reduce the sleep of mice that were given gamma-hydroxybutyric acid (GHBA), baclophen, or aminooxyacetic acid (AOAA) in combination with 3 g/kg/ ethanol. TRH also failed to reverse the hypothermia induced by the combination of ethanol and baclophen or GHBA, and the characteristic neurological effects of TRH e.g. tremor, increased muscle tone, and increased respiratory rate were reduced. In addition, TRH-induced locomotor stimulation was prevented by pretreatment with small doses of the GABA-ergic agents, and while 30 mg/kg TRH reduced the hypothermia produced by large doses of the GABA-ergic drugs, it did not antagonize the locomotor retardation produced by baclophen or GHBA. A hypothesis that the analeptic effects of TRH may be medicated via an inhibition of GABA systems is discussed.
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PMID:Antagonism of the analeptic activity of thyrotropin-releasing hormone (TRH) by agents which enhance GABA transmission. 1 50

An unusual case of Whipple's disease is reported. The diagnosis was difficult as the characteristic digestive sign and symptoms (malabsorption, diarrhea, mucosal infiltration by PAS-positive macrophages) were absent. After a ten-year history of seronegative arthritis, myocardiopathy, with aortic insufficiency, basilar pulmonary infiltrates, enlarged lymph nodes, the patient, a 56 years old man, was referred to us for a severe vegetative and neurological dysfunction: stupor, dysarthria, akinesia, hypertonia, hypothermia and abnormal thirst. A CT-scan showed a low-density area of the right hypothalamus, and PAS-positive macrophages were found in a lymph node, in the CSF and in a cerebral biopsy. The patient then received a classical antibiotic treatment, yet the neurologic dysfunction remained severe. Finally, a trial with rifampicin brought a striking improvement of the patient's condition, which has now lasted for three years.
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PMID:[Hypothalamic form of Whipple's disease. Favorable effect of rifampicin]. 619 50

The effects of morphine on body temperature have been shown to be altered by restraint. The purpose of this study was to determine how the type of restraint alters body temperature measurements and whether restraint alters the effects of morphine on body temperature by interfering with the ability of the rats to adjust their posture. The thermic effects of 5 doses of morphine (3.8 to 45 mg/kg) were compared in two types of restraint and confinement to a 13 X 20 X 20 cm pan without restraint. In unrestrained rats, morphine caused predominantly hyperthermia, but with restraint morphine caused hyperthermia at low doses and hypothermia at higher doses. Morphine hypothermia was greater in rats restrained in a wire-mesh restrainer which prevented heat and humidity build-up than in the commonly used plastic restrainer. In the unrestrained rats, morphine treatment was associated with a posture characterized by exophthalmos, immobility, a hunched position and increased muscle tone. Restrained rats could not assume a compact posture. These results suggest that restraint alters the thermic effect of morphine mainly by interfering with postural mechanisms which reduce heat loss.
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PMID:Restraint alters the thermic response to morphine by postural interference. 686 55

Vegetative disturbances were observed in 88 out of 102 patients, 86%, after a primary brain lesion during onset of brain death. Tachycardia was most common in 64%, hypotonia below 80 mm Hg and hypertonia above 170 mm Hg were present in about half of all cases. Hyperthermia above 40 degrees C was noted in 25%, hypothermia below 36 degrees C was observed in 31%. The kind of underlying brain lesion had no regular influence on the vegetative disturbances. In 5 out of 6 younger patients these disturbances were less pronounced.
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PMID:[Autonomic dysfunction and the development of secondary brain death syndrome]. 763 45

We describe herein the clinical symptoms, clinical course and results of investigation of 7 patients with bilateral basal ganglia-thalamic lesions (BBTL). All patients had spastic quadriplegia with rigidity. They were unable to sit and turn over. They could follow objects, turn head towards a sound and recognize parents to some degree. They were all evaluated as having the most severe degree of disability (Oshima's classification 1). They all had dysphagia and 2 patients had a episode of bradycardia and hypothermia, which might be evidences of brain stem disorders. Muscle hypertonia, vomiting, hematemesis and obstructive respiration, which were the major complications for the patients, worsened with age. High percentage of histories of birth asphyxia and poor feeding in the neonatal period suggested that perinatal brain insults might be one of the important factors for developing BBTL. It seemed to be difficult to explain that such diffuse brain injuries in our cases were caused by only the insults during parturition. Brain insults during parturition as well as prenatal factors probably participate in developing BBTL. Although the cerebrum of the patients seem to be relatively preserved in the images of head CT-scan, MRI of the patients revealed diffuse brain lesions. All of five patients tested had an abnormal auditory brain stem response (ABR). These investigations demonstrated that patients with BBTL have diffuse brain damage including brain stem. Further observation is needed to verify the mechanisms of development and the time of onset of BBTL.
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PMID:[Clinical consideration of patients with neonatal bilateral basal ganglia-thalamic lesion due to hypoxic ischemic encephalopathy]. 807 89