Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Spontaneous adult-onset hypothyroidism, confirmed by a thyroid-stimulating hormone stimulation test, thyroid biopsy, and response to replacement therapy, is described in a female cat. Clinical signs consisted of profound apathy, hypothermia, poor hair growth, severe seborrhea sicca, and a puffy face. Cutaneous histological changes consisted of epidermal and follicular hyperkeratosis, teloginization of hairs, and dermal mucin deposition. There was no adnexal atrophy. Lymphocytic thyroiditis, equivalent to Hashimoto's thyroiditis, was shown by thyroid biopsy. Clinical signs rapidly responded to thyroxine replacement therapy. Glucose intolerance was coexistent with the hypothyroidism, but was not dramatically influenced by thyroxine therapy and probably was an independently occurring endocrinopathy.
 ...
PMID:Spontaneous adult-onset hypothyroidism in a cat. 826 45

We administered anesthesia for a 20-month-old boy with non-bullous ichthyosiform erythroderma who underwent orthopedic syndactyly repair on two occasions. Anesthetic considerations include the difficult fixation of the tracheal tube and iv cannulas and the risk of hypothermia. Intravenous access placement was also difficult due to the hyperkeratosis and the deformity of extremities. In the first surgery, pharyngeal temperature fell to 34.4 degrees C despite the use of the 37 degrees C circulating water mattress and room temperature set to 26 degrees C. It gradually returned to 36 degrees C during the surgery. We applied Steri-Strip compound benzoin tincture to the skin to increase adhesiveness before taping the tracheal tube. It resulted in a good fixation but difficult removal. In the second surgery, we fixed the tracheal tube with a tube holder which enabled the fixation without the use of adhesive tapes to the skin. To maintain body temperature we used forced air warming device Bair Huggar, which was very useful to avoid hypothermia but resulting in a rather high body temperature. In conclusion, a tube holder was an effective device to fix the tracheal tube in this patient. Forced air warming device was useful to prevent hypothermia.
 ...
PMID:[Anesthetic considerations for a boy with non-bullous ichthyosiform erythroderma]. 2138 73

A retrospective study revealed ten cases of emphysematous ingluvitis in Loriinae birds from two zoological collections between 2009 and 2020. Common clinical features were sudden death with gas distention of the crop, subcutaneous cervical emphysema and poor body condition, but also included collapse, hypothermia and abandonment. Macroscopic examination revealed moderate crop enlargement, distention and thickening with minimal intraluminal content, and moderate to severe submucosal to transmural gas-filled cysts (emphysema). Histopathology identified widespread transmural multifocal to coalescing empty pseudo-cystic cavities with lytic necrosis, pyo-/granulomatous inflammatory infiltrates, epithelial ulceration, parakeratotic hyperkeratosis, epithelial ballooning degeneration, and occasional intralesional rod-shaped bacteria. The lesion may have impaired the birds' ability to ingest food, resulting in suboptimal body condition. Necrotizing to granulomatous aspiration pneumonia was also a feature in some cases. Anaerobic bacterial culture of four crops identified Clostridium perfringens with associated toxin genes for alpha and occasionally beta2 toxin (cpa and cpb2 genes respectively), by PCR analysis of bacterial isolates cultured from fresh or frozen tissue. C. perfringens was identified as the common etiological agent of emphysematous ingluvitis in crop and/or liver (six out of ten birds), and type A was confirmed in five birds. C. perfringens was not detected in the crop nor liver of two unaffected Loriinae birds. This is the first publication that characterizes nectarivorous bird emphysematous ingluvitis (NBEI), attributes C. perfringens as an etiological agent, and highlights this novel disease as an important cause of death in Loriinae birds, particularly in nestling and fledgling stage of development, but also in older lorikeets and lories.
 ...
PMID:Nectarivorous Bird Emphysematous Ingluvitis (NBEI): A Novel Disease in Loriinae Birds Associated With Clostridium perfringens Infection. 3325 Dec 74