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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Postoperative hyperplasia enhances experimental intestinal carcinogenesis, but the effects of nonsurgical adaptation are uncertain. The tropic and tumour-promoting potentials of moderate hypothermia were tested in two groups of male Sprague-Dawley rats housed at 10 degrees C for 30 weeks. One group (n = 10) received a 6-week course of azoxymethane (total dose 90 mg kg-1). The second group (n = 7) acted as hypothermic controls. Another 2 groups maintained at 22 degrees C received azoxymethane (n = 15) or served as normothermic controls (n = 15). Overall food intake was 42% higher in the hypothermic groups, yet at sacrifice mean body weight was 13% lower (P less than 0.01). Hypothermia and azoxymethane combined to produce the following increases in crypt cell production rate (CCPR), as determined stathmokinetically: duodenum 170%, jejunum 172%, ileum 74%, proximal colon 227% (P = 0.05-0.01). Independently hypothermia had no effect, but azoxymethane produced 76-156% increases in CCPR throughout the large intestine. Although hypothermia did not affect overall tumour yield, the mean diameter of proximal colonic tumours was increased by 65% (P less than 0.05). In rats receiving azoxymethane, hypothermia stimulates cell proliferation in the small bowel as well as in the proximal colon, where it has a correspondingly mild cocarcinogenic effect.
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PMID:Effect of hypothermia on intestinal adaptation and carcinogenesis in the rat. 356 60

To substantiate some concepts of an oxygen-peroxide model of carcinogenesis, a number of experiments were conducted, and also the data were utilized previously obtained by the writers on the directed flow of water dissolved oxygen influenced by a permanent magnetic field. The observed suppressive action of the magnetic field on the growth of transplantable Pliss lymphosarcoma and PC-1 tumor may be accounted for the latter uncoupling oxygen in actively growing hyperoxic neoplastic cells from other participants of the direct free radical oxidation, spliting or minimizing in them closed cycles of reproduction of toxic products of lipids hyperoxidation. The enhanced effect of magnetic therapy under hypothermia is due to the well-known property of oxygen to change its magnetic susceptibility under the influence of temperature.
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PMID:[Enhanced antitumor effect in the combined action of a magnetic field and hypothermia]. 689 43

An account is given of the "oxygen theory" of biomagnetic effects, whereby molecular oxygen is the primary, elementary, and fundamental material affected by the influence of a permanent magnetic field (PMF). The ability of a PMF to alter inductively the motion of paramagnetic O2 dissolved in a fluid, and to uncouple it from other substances which participate in oxidative processes leads, first of all, to a disturbance of O2 transport and to a disturbance of cellular bioenergetic processes. A series of biomagnetic effects are explainable on the basis of the suggested mechanism. Experimental data regarding changes in pO2 in tumor tissue under the influence of a PMF, and data concerning the inhibition of growth of reinoculated tumors (Pliss' lymphosarcoma and RS-1) under the combined influence of PMF and hypothermia, are given as indirect support of the oxygen mechanism of PMF effects and the oxygen-peroxide mechanism of carcinogenesis.
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PMID:Permanent magnetic fields: influence on oxygen-substrate interactions and possible mechanisms of several biomagnetic effects. 689 5

Cold-inducible RNA binding protein (CIRP) was discovered after the cells were exposed to a moderate cold shock because its production was induced. Other cellular stresses such as ultraviolet light radiation and hypoxia also could increase its expression. Under stress conditions, CIRP could up regulate its own expression by self-transcriptional activation of alternative promoters. After relocating into cytoplasm from nucleus, CIRP assists cells in adapting to novel environmental conditions via stabilizing specific mRNAs and facilitating their translation. It not only participates in anti-apoptosis processes under mild hypothermia condition, but also protects cells from ultraviolet radiation and hypoxia induced senescence process. This article focuses on the possible mechanisms of its inducible expression, cytoprotective functions and carcinogenesis. In addition, extracellular CIRP has been shown to be a novel danger-associated molecular patter (DAMP) member and is able to induce inflammatory response. Finally, based on the distinct roles of CIRP in intracellular and extracellular conditions, a possible model of CIRP-mediated cell fate has been proposed.
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PMID:The role of cold-inducible RNA binding protein in cell stress response. 2860 39

Low-temperature treatments (i.e., hypothermia) may be one way of regulating environmental radiation damage in living systems. With this in mind, hibernation under hypothermic conditions has been proposed as a useful approach for long-term human space flight. However, the underlying mechanisms of hypothermia-induced radioresistance are as yet undetermined, and the conventional risk assessment of radiation exposure during hibernation remains insufficient for estimating the effects of chronic exposure to galactic cosmic rays (GCRs). To promote scientific discussions on the application of hibernation in space travel, this literature review provides an overview of the progress to date in the interdisciplinary research field of radiation biology and hypothermia and addresses possible issues related to hypothermic treatments as countermeasures against GCRs. At present, there are concerns about the potential effects of chronic radiation exposure on neurological disorders, carcinogenesis, ischemia heat failures, and infertility in astronauts; these require further study. These concerns may be resolved by comparing and integrating data gleaned from experimental and epidemiological studies.
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PMID:The Effect of Low Temperatures on Environmental Radiation Damage in Living Systems: Does Hypothermia Show Promise for Space Travel? 3288 91