Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of two Ca2+ channel inhibitors (CCIs) on ethanol-induced hypothermia and hypnosis, on tolerance formation to both effects, and on audiogenic convulsions during ethanol withdrawal was studied in rats. Nifedipine, 2 and 5 mg/kg IP, significantly augmented the hypnotic action of ethanol without affecting hypothermia. Diltiazem failed to influence either effect of the toxin. Rectal temperature did not change in ethanol-naive rats after acute injection of diltiazem or nifedipine. Both drugs dose-dependently suppressed the development of tolerance to the hypothermic effect of ethanol without affecting the tolerance to the hypnotic action. Only nifedipine markedly suppressed the audiogenic seizure response in ethanol withdrawn animals. These data suggest that Ca2+ channels play a role in both acute and chronic effects of ethanol while pointing to certain differences in behavioral effects of various CCIs.
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PMID:Different effect of diltiazem and nifedipine on some central actions of ethanol in the rat. 271 89

The influence of ciprofloxacin, ofloxacin and pefloxacin on acute toxicity of ethanol, ethanol-induced hypothermia, ethanol sleeping time was investigated in mice. Moreover, the combined effect of fluoroquinolones and ethanol on spontaneous locomotor activity, motor coordination in mice and ethanol abstinence syndrome in rats was examined. The fluoroquinolones (20 and 80 mg/kg) were injected intraperitoneally. The drugs were given in single or repeated doses for 7 days. In acute experiments, drugs were given 30 min before ethanol administration. In chronic experiments, the last dose of fluoroquinolones was given 18 h prior to ethanol injection. It has been shown that the fluoroquinolones decrease acute toxicity of ethanol, antagonize its hypothermic effect, decrease ethanol inhibitory effect on motor coordination in mice, and increase ethanol-induced hypermotility in mice and audiogenic seizure response in rats during alcohol abstinence syndrome. Ciprofloxacin and ofloxacin administered repeatedly increase the influence of ethanol on duration of ethanol-induced sleep. The influence of fluoroquinolones on ethanol central action depends on the drug used, its dose and route of administration.
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PMID:Influence of fluoroquinolones on the central action of ethanol. 1038 47