Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Somatosensory evoked potential after posterior tibial nerve stimulation (PTN-SEP), as well as nasopharyngeal, bladder and plantar temperature were recorded in ten patients during cardiac surgery with hypothermic cardiopulmonary bypass. There was a best negative correlation between latencies (P27, P40 and the interpeak latency between P40 and P27 (P40-P27)) and nasopharyngeal temperature, but no correlation was found between latencies and plantar temperature during cooling and rewarming (27-37 degrees C) with cardiopulmonary bypass. No correlation was found between changes in amplitude and temperature. The slope of linear regression line of latencies versus nasopharyngeal temperature was -1.05 msec.degrees C-1 for P27 (r = -0.93), -1.47 msec.degrees C-1 for P40 (r = -0.95) and -0.43 msec.degrees C-1 for P40-P27 (r = -0.78). This study suggests that nasopharyngeal temperature measurement is required to aid the interpretation of PTN-SEP changes during hypothermia.
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PMID:[Effects of hypothermia with cardiopulmonary bypass on posterior tibial nerve somatosensory evoked potentials in man]. 149 79

We sought to determine whether pentobarbital (PB) coma compromises the use of evoked potentials (EPs) in the assessment of brain dysfunction and of the prognosis of severely head-injured patients. Therefore, the effects of therapeutic PB on somatosensory (SEPs, BSEPs), visual (VEPs), and auditory (BAEPs) evoked potentials recorded from 20 patients early after injury were analyzed. Seventeen head-injured patients served as controls. EP studies were obtained shortly after admission (Mean Day 2, PB present) and approximately 2 weeks after injury (Mean Day 15, PB absent). The mean serum level of PB in the treatment group was 1.9 mg/100 ml. The drug effect was assessed by comparisons between the PB and the control groups. Statistical analyses were based on differences observed between two studies in the same patient. Analyses of covariance (F tests) were performed on data from all modalities. Wave form complexity was minimally affected by the drug. Middle and long latency components of the SEP were depressed by PB, and latencies of BSEP peaks and the early components of the SEP were delayed. The amplitude of some VEP peaks was reduced by PB. The BAEP was not significantly altered. All of the observed effects of PB were determined to be due to the hypothermia exhibited by PB-treated patients (mean temperature, 36.1 degrees C), which was not seen in the control group (mean, 37.8 degrees C). It is concluded that, with appropriate interpretation, EPs can be used to monitor brain function in head-injured patients when PB therapy is used.
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PMID:Effects of therapeutic pentobarbital coma on multimodality evoked potentials recorded from severely head-injured patients. 687 43

The surgical repair of ascending aorta aneurysms can only be carried out under total circulatory arrest, and is consequently to be performed under deep hypothermia, in order to adequately decrease the metabolic requirements of the brain. However, the optimal temperature to be reached is poorly known. SEPs to median nerve stimulation were recorded in 21 operations performed in 20 patients undergoing profound hypothermia. The latencies of all SEP components increase to 21 degrees C. Waves N20 and P14 disappear at mean naso-pharyngeal temperatures of 20 degrees C and 17 degrees C, respectively, although a wide inter-individual variability was observed. We suggest to use the P14 disappearance as the criterion to perform the circulatory arrest: in fact, all surviving patients in whom this criterion was fulfilled recovered without any detectable neurological sequellae, while three patients in whom brain activities disappeared independently on body temperature presented with neurological sequellae. Moreover, particularly if patients presenting with ischemia-induced disappearance of Erb's point activities were excluded, we found a significant correlation between the duration of the circulatory arrest and the delay of N20 and P14 reappearance on rewarming. This confirms the importance of sufficient hypothermia, on the one hand; and on the other hand, our findings imply that, even if SEP monitoring considerably decreases the risk of neurological sequellae associated with these operations, the duration of the circulatory arrest should be reduced as far as possible.
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PMID:[Somatosensory evoked potentials in patients undergoing circulatory arrest under profound hypothermia]. 832 30

Past over two years, thirteen cases of aortic arch aneurysm, including 5 proximal arch aneurysms, 5 transverse arch aneurysms and 3 distal arch aneurysms, were operated under retrograde cerebral perfusion with deep hypothermia. In the operation, tympanic temperature, rectal temperature and SEP were monitored. When the rectal temperature fell to 20 degrees C, circulatory arrest was done and retrograde cerebral perfusion was started through SVC venous cannula, at the rate of 200-300 ml/min. During cerebral perfusion, PGE1, Mannitol, Solumedrol were administered and defroxamine as radical scavenger was injected before reperfusion for protection of the brain edema. The duration of retrograde cerebral perfusion was from 28 min to 67 min. (mean 42.8 min). In the retrograde cerebral perfusion, cerebral embolization was prevented and good operative field without cannulation was obtained. Of 13 patients, 3 patients were died of intraoperative myocardial infarction and acute renal failure. Ten patients were alive and recovery of consciousness was complete. In conclusion, retrograde cerebral perfusion method is very simple and useful for the operation of aortic arch aneurysm.
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PMID:[Retrograde cerebral perfusion with circulator arrest for aortic arch aneurysm]. 837 29