Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Concomitant application of hyperthermia, bleomycin and irradiation led to a maximal effect, compared with findings in cells treated with a single or two modalities in vitro. The synergistic effect of the combination with hyperthermia and irradiation was exhibited in all layers of multicellular tumor spheroids (MTS). The combined effects of water-bath hypothermia at 42.5 degrees C for 30 min, 1/10 LD50 bleomycin iv, and 200 rad irradiation were also demonstrated in DDD strain male mice with Ehrlich ascites tumor. According to the results of in vitro and in vivo studies, hyperthermia combined with irradiation and chemotherapy was prescribed for patients with squamous cell carcinoma of the esophagus. The long term results were compared between two groups of patients treated with hyperthermo-chemo-radiotherapy and those treated with chemo-radiotherapy but not hyperthermia. The five year survival rates of patients with resectable carcinoma, given preoperative hyperthermo-chemo-radiotherapy or chemo-radiotherapy were 43.2% and 14.7%, respectively. As severe side effects in patients given hyperthermia were nil, this treatment deserves serious consideration when treating patients with a malignant lesion of the esophagus.
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PMID:[Basic and clinical investigations of the effectiveness of hyperthermia combined with chemotherapy and irradiation in the treatment in patients with esophageal carcinoma]. 248 61

A 70-year-old man presented with severe angina pectoris caused by critical stenosis of the left anterior descending coronary artery 11 years after mediastinal radiation therapy, esophagectomy and substernal colon interposition for squamous cell carcinoma of the esophagus. Coronary artery bypass was performed through a left thoracotomy using the left internal mammary artery with profound hypothermia. This uncommon approach to an unusual case is described here.
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PMID:Coronary artery bypass after substernal colon interposition for carcinoma of the esophagus. 804 87