Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty female long-tailed macaques received nasogastric intubation of 0-600 micrograms/kg-day L-selenomethionine for up to 30 consecutive days. Selenium ingestion was well tolerated at all dose levels until the second to third week of the study at which time two animals given 600 micrograms/kg-day died. One animal from the 300 micrograms/kg-day group was removed from study on Treatment Day 19 due to selenium-induced hypothermia. In some cases, administered doses were reduced at the 300 and 600 micrograms/kg-day levels such that the final time-weighted average doses were 0, 25, 62-117, 150, 188-203, and 300 micrograms/kg-day. Six animals at the 188 micrograms/kg-day level or greater required nonscheduled fruit and dietary supplementation to prevent their impending demise. As the dose and duration of exposure increased, the incidence of anorexia, gastrointestinal distress, mucocutaneous toxicity, and frequency of reduced body temperature also increased. A dose-dependent reduction in body weight was also observed. At the greater doses, disturbances in menstrual function were evident, and were accompanied by the absence of serum progesterone concentrations above 1.0 ng/ml, reduced luteal phase lengths, increased intermenstrual intervals, and lowered estrogen excretion. A maximum tolerated dose of 150 micrograms/kg-day L-selenomethionine for 30 days was identified based on mean body weight reduction, hypothermia, dermatitis, xerosis, cheilitis, disturbances in menstruation, and the necessity of dietary intervention to prevent death at doses of 188 micrograms/kg-day or greater.
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PMID:30-day oral toxicity study of L-selenomethionine in female long-tailed macaques (Macaca fascicularis). 276 59

Winter climate is prone to induce cutaneous and systemic alterations mediated by cold. Xerosis due to the impairment of the desquamation process is not rare on the limbs. Chilbain results from reversible alterations of the dermal vasculature. Cold panniculitis is the consequence of lipid crystallization within adipocytes. More dramatic issues occur when cold exposure extends beyond skin. They are represented by frostbite and body hypothermia. Intensity and duration of cold exposure combined with wind speed, altitude and environmental hygrometric value govern the potential type of low temperature-dependent pathology. Ultraviolet irradiation can also induce cutaneous lesions during winter time.
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PMID:[Winter skin diseases]. 1066 45