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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six female and 4 male patients (age, 23 to 75 years) underwent operation for difficult intracranial lesions. Preoperative diagnoses included four giant intracranial aneurysms, three base of skull glomus jugulare tumors, two arteriovenous malformations, and one cerebellar hemangioblastoma. All lesions were inoperable or nearly so by standard neurosurgical techniques. All patients were placed on total bypass via groin cannulations. Bypass times ranged from 111 to 269 minutes (mean, 174 minutes) with cooling times of 26 to 83 minutes (mean, 48 minutes) and warming times of 68 to 110 minutes (mean, 83 minutes). Circulatory arrest times ranged from 1.25 to 60 minutes with 1 patient not requiring arrest. The lowest core temperatures recorded varied from 8.4 degrees to 13.7 degrees C. There was one postoperative death and one major complication, both in patients with arteriovenous malformations. Eight patients (80%) have achieved an excellent result. Profound hypothermia with the option of circulatory arrest and exsanguination has been an indispensable adjunct to the safe management of intracranial aneurysm, glomus jugulare tumor, and hemangioblastoma.
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PMID:Cardiopulmonary bypass, profound hypothermia, and circulatory arrest for neurosurgery. 151 May 42

Although cardiopulmonary bypass (CPB) with hypothermia and circulatory arrest is routinely used for certain cardiovascular procedures, its advantages have infrequently been applied for other unusual surgical problems. Fourteen patients (six men and eight women, average age 48 years, range 29 to 74 years) underwent 15 operations over a 4-year period beginning in November 1978. Preoperative diagnosis included giant middle cerebral aneurysm (n = 8), internal carotid aneurysm (3), basilar artery aneurysm (2), and medullary hemangioblastoma (2). All patients had lesions that were considered inoperable by standard neurosurgical techniques. Operative technique consisted of peripheral cannulation with a long and short femoral vein cannula for venous return (24 to 28F) and a single femoral arterial cannula (18 to 24F). CPB flows ranged from 1 to 3.5 L/min, and the total CBP times averaged 146 minutes (range 66 to 282 minutes). Circulatory arrest times averaged 21 minutes (range 5 to 51 minutes), with two patients having no period of circulatory arrest. Lowest core temperature ranged from 16 degrees to 20 degrees C, with cooling and rewarming aided by Brown-Harrison heat exchangers placed in a countercurrent fashion within the venous return line. The heart spontaneously defibrillated in six patients, and external countershock was required in nine patients. No difficulty was encountered with cardiac distention. The intended operation was accomplished in all cases with 13 of 14 patients being discharged from hospital, having had a good neurosurgical result. One patient sustained a hemorrhagic infarction of the cerebellum and pons and is presently recovering. Our experience indicates that peripheral CPB with induced hypothermia and circulatory arrest is a safe technique for approaching otherwise inoperable neurosurgical lesions.
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PMID:Reappraisal of cardiopulmonary bypass with deep hypothermia and circulatory arrest for complex neurosurgical operations. 687 41

A case of medullary hemangioblastoma treated with radiation and operation is presented. After radiation a 55% decrease in the volume of the vascular portion of the tumor was documented by angiograms. Also, there were planes of dissection between the tumor and the dorsal medulla that had not been appreciated at exploratory operation before radiation. Total resection of the tumor was accomplished using hypothermia and cardiac standstill. The literature detailing the effects of radiation on hemangioblastoma is reviewed. (Neurosurgery, 6: 82--86, 1980)
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PMID:Effect of radiation therapy on hemangioblastoma: a case report and review of the literature. 735 2

Hypothermia and cardiopulmonary bypass has rarely been used for difficult lesions of the brain such as giant aneurysms and hemangioblastoma of the brainstem. We report a case of huge recurrent angioblastic meningioma operated under the profound hypothermia and cardiopulmonary bypass. We reviewed the complications related to hypothermia and cardiopulmonary bypass for brain lesions.
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PMID:Profound hypothermia and cardiopulmonary bypass in the treatment of recurrent giant angioblastic meningioma case report. 893 3