Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We evaluated the effects of WR-2721 and its metabolite WR-1065 on in vitro growth inhibition by 5-fluorouracil (5FU) and cisplatin (CDDP) and the effect of WR-2721 on in vivo toxicity and antitumor effect of 5FU and CDDP. In cell culture both WR-2721 and WR-1065 were not able to reverse growth inhibition caused by either 5FU or CDDP. Administration of WR-2721 i.p. at 525 mg/kg to mice resulted in a severe temperature drop to 27 degrees C; at 200 mg/kg hypothermia was less severe. WR-2721 failed to prevent 5FU toxicity, but the maximum tolerated dose of CDDP in the combination with 5FU (at 100 mg/kg) could be increased from 3 to 7 mg/kg. CDDP at 7 mg/kg enhanced leukopenia caused by 5FU at 100 mg/kg to 20% and thrombocytopenia to 40%; WR-2721 reduced leukopenia and prevented thrombocytopenia induced by the combination. Combination of CDDP, 5FU, and WR-2721 resulted in an enhanced antitumor activity against the murine colon tumor Colon 26 compared to 5FU alone and to 5FU combined with CDDP at their maximum tolerated dose.
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PMID:Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouracil. 131 75

Unrecognized and untreated intraoperative hypothermia remains a common avoidable scenario in the modern operating room. Failure to properly address this seemingly small aspect of the total operative care has been shown to have profound negative patient consequences including increased incidence of postoperative discomfort, surgical bleeding, requirement of allogenic blood transfusion, wound infections, and morbid cardiac events. All of these ultimately lead to longer hospitalizations and higher mortality. To avoid such problems, simple methods can be employed by the surgeon, anesthesiologist, and ancillary personnel to ensure euthermia. Similarly, another effortless method to potentially improve surgical outcomes is the liberal use of supplemental oxygen. Promising preliminary data suggests that high-concentration oxygen during and after surgery may decrease the rate of surgical site infections and gastrointestinal anastomotic failure. The precise role of supplemental oxygen in the perioperative period represents an exciting area of potential research that awaits further validation and analysis. In this article, the authors explore the data regarding both temperature regulation and supplemental oxygen use in an attempt to define further their emerging role in the perioperative care of patients undergoing colorectal surgery.
Clin Colon Rectal Surg 2009 Feb
PMID:Temperature control and the role of supplemental oxygen. 2011 52