Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To substantiate some concepts of an oxygen-peroxide model of carcinogenesis, a number of experiments were conducted, and also the data were utilized previously obtained by the writers on the directed flow of water dissolved oxygen influenced by a permanent magnetic field. The observed suppressive action of the magnetic field on the growth of transplantable Pliss lymphosarcoma and PC-1 tumor may be accounted for the latter uncoupling oxygen in actively growing hyperoxic neoplastic cells from other participants of the direct free radical oxidation, spliting or minimizing in them closed cycles of reproduction of toxic products of lipids hyperoxidation. The enhanced effect of magnetic therapy under hypothermia is due to the well-known property of oxygen to change its magnetic susceptibility under the influence of temperature.
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PMID:[Enhanced antitumor effect in the combined action of a magnetic field and hypothermia]. 689 43

An account is given of the "oxygen theory" of biomagnetic effects, whereby molecular oxygen is the primary, elementary, and fundamental material affected by the influence of a permanent magnetic field (PMF). The ability of a PMF to alter inductively the motion of paramagnetic O2 dissolved in a fluid, and to uncouple it from other substances which participate in oxidative processes leads, first of all, to a disturbance of O2 transport and to a disturbance of cellular bioenergetic processes. A series of biomagnetic effects are explainable on the basis of the suggested mechanism. Experimental data regarding changes in pO2 in tumor tissue under the influence of a PMF, and data concerning the inhibition of growth of reinoculated tumors (Pliss' lymphosarcoma and RS-1) under the combined influence of PMF and hypothermia, are given as indirect support of the oxygen mechanism of PMF effects and the oxygen-peroxide mechanism of carcinogenesis.
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PMID:Permanent magnetic fields: influence on oxygen-substrate interactions and possible mechanisms of several biomagnetic effects. 689 5