Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study on septicemia in the elderly (mean age 80.3 +/- 9.1 years) was carried out during 1982-85. A total of 184 episodes of bacteremia occurred in 175 patients (incidence rate 7.2%); 61% were attributed to community-acquired sepsis. Gram-negative microorganisms accounted for 64% of all episodes and gram-positive for 30%. The overall mortality was 18.3%. Using univariate analysis, significant factors associated with a high mortality were: hospital-acquired sepsis, respiratory infections as source of the sepsis, severe underlying disease, Klebsiella and Proteus as pathogens, comatose state, hypothermia, thrombocytopenia, and serum sodium abnormalities. Using logistic regression analysis the odds ratio for hospital-acquired septicemia and hypothermia were positive and statistically significant, whereas soft tissue and urinary tract infections as sources were negative and significant. The relative low mortality in our study confirms that age alone is not necessarily a poor prognostic indicator of septicemia in the elderly.
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PMID:Septicemia in the elderly: incidence, etiology and prognostic factors. 234 81

A series of experiments was designed to investigate the influence of acute renal failure on selected gastrointestinal bacteria. Sprague-Dawley male rats were bilaterally nephrectomized to induce acute renal failure, with sham-operated animals serving as controls. After 48 h animals were sacrificed and the stomachs, upper and lower small intestines, ceca, and colons were excised and subjected to microbial analyses. Lactobacilli and streptococci including enterococci, were 1-2 log counts higher in the stomachs of anephric rats than those of sham-operated controls; lactobacilli were increased similarly in the upper small intestines of these animals. Coliforms including Escherichia coli, and Proteus were 1-2 log counts higher in the lower small intestine of anephric rats than those of sham-operated rats. The decreased gastric pH, increased cecal pH, hypothermia, and delayed gastric emptying observed in nephrectomized rats could partly explain the different microfloras in these animals.
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PMID:Influence of bilateral nephrectomy on selected gastrointestinal bacteria in the rat. 710 54

The rate of perinatal death is variable but highest during parturition, immediately after birth and in the first days of life. Infectious diseases, above all bacterial, are the second most important cause of mortality after losses during parturition. A lot of factors are involved predisposing puppies and kittens to bacterial infections: respiratory distress, hypothermia, hypoglycaemia, dehydration, congenital abnormalities. E. coli, streptococci and staphylococci, Klebsiella sp., Pseudomonas sp., Enterobacter sp., Proteus sp. and anaerobes are regularly involved in bacterial infections in neonates. Postmortem findings especially document E. coli, Staphylococcus or Streptococcus species as causes of disease and death shortly after birth. The environment and mothers are suspected as sources of infection (vaginal discharge, milk, faeces, oropharynx, skin) for puppies and kittens. Genetic relatedness of bacterial strains in puppies and their mothers was found in staphylococci and E.coli. These results indicate that for repeated cases of bacterial infections in neonates diagnostic procedures of milk, vaginal and faecal swabs from bitches result in isolation of the responsible bacteria with a high probability and suggest that preterm treatment could help to control bacterial diseases and losses in pups.
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PMID:The pathological newborn in small animals: the neonate is not a small adult. 1868 49

BACKGROUND Previous studies have shown that a neotype rectal cooling device can induce mild hypothermia (MH) in Sprague-Dawley rats with ischemic-hypoxic brain damage (HIBD) and inhibit cell apoptosis in the hippocampal CAl region, and does not cause damage to rectal tissues. The present study aimed to investigate the effect of rectal MH on bacterial translocation (BT) in Sprague-Dawley rats with HIBD. MATERIAL AND METHODS A total of 60 Sprague-Dawley rats were randomly divided into 4 groups: a control group (group C), a normothermia group (group NT), a cooling blanket group (group CB), and a rectal cooling group (group RC). Rats in group CB and group RC received MH using a cooling blanket and rectal cooling device after HIBD model establishment. Then, we measured diamine oxidase (DAO) and D-lactate level separately in groups NT, CB, and RC. Finally, the spleen, liver, and mesenteric lymph nodes were collected for bacterial culture, and rectal tissues were collected for H&E staining. RESULTS The therapeutic outcome was better in Sprague-Dawley rats receiving rectal MH without rectal injury compared to rats in group CB. Escherichia coli (E. coli) was found in MLNs in group RC. E. coli, Proteus vulgaris, Stenotrophomonas maltophilia, and Acinetobacter lwoffii were detected in the rats of groups CB and NT. At 12 h following rectal MH, DAO and D-lactate levels were lower than in group NT. CONCLUSIONS The neotype rectal MH cooling method could be a potential strategy to induce rapid, controllable hypothermia, thus reducing the possibility of inflammatory cell infiltration and BT incidence.
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PMID:Effect of Neotype Rectal Mild Hypothermia Therapy on Intestinal Bacterial Translocation in Rats with Hypoxic-Ischemic Brain Damage. 3201 61