Gene/Protein
Disease
Symptom
Drug
Enzyme
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Pivot Concepts:
Gene/Protein
Disease
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Drug
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Target Concepts:
Gene/Protein
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Query: UMLS:C0020672 (
hypothermia
)
17,327
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The present study was undertaken to investigate the influence of
hypothermia
on endothelium-independent vascular smooth muscle contractility and to determine the mechanism underlying the relaxation. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments.
Hypothermia
significantly inhibited fluoride-, thromboxane A
2
-, phenylephrine-, and phorbol ester-induced vascular contractions regardless of endothelial nitric oxide synthesis, suggesting that another pathway had a direct effect on vascular smooth muscle.
Hypothermia
significantly inhibited the fluoride-induced increase in pMYPT1 level and phorbol ester-induced increase in pERK1/2 level, suggesting inhibition of Rho-kinase and MEK activity and subsequent phosphorylation of
MYPT1
and ERK1/2. These results suggest that the relaxing effect of moderate
hypothermia
on agonist-induced vascular contraction regardless of endothelial function involves inhibition of Rho-kinase and MEK activities.
...
PMID:Hypothermia Inhibits Endothelium-Independent Vascular Contractility via Rho-kinase Inhibition. 2820 12
