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Two cases of severe hepatic injury in which selective hepatic artery embolization was used to control hemorrhage are presented. The first case is that of a 35 year old patient who sustained a severe liver injury after a car accident. A CAT scan of the abdomen revealed an AAST grade 5 liver injury, pooling of contrast material within the liver parenchyma, and blood within the peritoneal cavity. The patient was given fluid resuscitation and taken to angiography where bleeding from branches of the right hepatic artery was demonstrated. While angiography was being undertaken the hemodynamic status of the patient deteriorated, blood transfusion was started, and a selective embolization of the right hepatic artery was performed. The bleeding stopped promptly and hemodynamic stability was regained. The second case is that of a 40 year old pedestrian run over by a car. Abdominal ultrasound revealed free fluid in the peritoneal cavity and the patient was rushed to the O.R. Crushed right lobe of the liver, and inferior vena cava and bowel tears were found. After perihepatic packing and resection of the right and sigmoid colons retrohepatic vena cava tear was repaired and perihepatic packing restored. The abdominal cavity was closed and the patient was taken to the ICU for the correction of hypothermia, metabolic acidosis, and coagulopathy that had developed during the surgery. After 8 hours in the ICU the patient was transferred for angiography and a selective embolization of branches of the right hepatic artery was performed. The clinical course of the patients after angiographic embolization of the hepatic arteries is described and the literature that discusses the use of angiography and embolization of hepatic arteries after traumatic hepatic bleeding is reviewed.
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PMID:[Selective embolization of hepatic arteries--an additional precaution to control hemorrhage in the management of severe liver trauma]. 1130 40

Trauma deaths continue to show a trimodal distribution: immediately at the scene, within the first 24 hours during initial resuscitation, and in the next 3 to 4 weeks as a result of multiple organ failure.(1) Failure to resuscitate adequately in the emergency department can lead to acidosis, hypothermia, and coagulopathy, which can result in multiple organ failure and cause death in these patients. Our current understanding of the initial response to shock and trauma and the development of the systemic inflammatory response syndrome and progressive organ failure is one of a continuum initiated and perpetuated by inflammation and inflammatory mediators. The pathophysiologic character, diagnosis, prevention, and treatment of traumatic injury-induced multiple organ failure are discussed.
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PMID:A current concept of trauma-induced multiorgan failure. 1146 13

In management of severe trauma patients, trauma surgeons need to decide which patients are eligible for damage control. Such decision may be supported by utilizing models that predict the patient's outcome. The study described in this paper investigates the possibility to construct patient outcome prediction models from retrospective patient's data at the end of initial damage control surgery by using feature mining and machine learning techniques. As the data used comprises rather excessive number of features, special attention was paid to the problem of selecting only the most relevant features. We show that a small subset of features may carry enough information to construct reasonably accurate prognostic models. Furthermore, the techniques used in our study identified two factors, namely the pH value when admitted to ICU and the worst partial active thromboplastin time, to be of highest importance for prediction. This finding is pathophysiologically reasonable and represents two of three major problems with severe trauma patients, metabolic acidosis, hypothermia, and coagulopathy.
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PMID:Feature mining and predictive model construction from severe trauma patient's data. 1151 64

Pediatric trauma management requires both operative and nonoperative (supportive) care. Fewer than 15% of pediatric trauma patients require surgery (Children's Hospital of Michigan Registry Data, excluding fractures), and the primacy of closed head injury and the multisystem nature of pediatric trauma dictate assessment and therapy. Complications arise at every level, including fluid resuscitation (too much or too little), antibiotics (too late), or pain control (inadequate). The institution of mechanical ventilation that is usually life-saving carries its own risks including those associated with intubation (perforation, aspiration, pro longed endotracheal intubation (stricture, pneumonia), and barotrauma (ventilator-induced lung injury). Minor procedures, such as thoracentesis, chest tube insertion, and pericardiocentesis, can all be complicated by perforation and hemorrhage. Major interventions, including laparotomy and thoracotomy, can result in hemorrhage, air leak, abdominal compartment syndrome, phrenic nerve and thoracic duct injury, postoperative abscess, and septicemia. Transfusion, cardiopulmonary bypass, and invasive monitoring can result in coagulopathy and vascular injury. Prolonged resuscitation and operative explorations can cause hypothermia and coagulopathy and initiate a cascade of multiorgan failure and ARDS. There is no doubt that rapid evacuation, prompt resuscitation, and organized systems of pediatric trauma care have reduced the overall mortality of childhood trauma. The higher velocity of travel and an increasingly chaotic urban environment have resulted in more multitrauma cases and in injuries of higher severity requiring more sophisticated and complicated diagnostic and therapeutic modalities. Our ability to identify life-threatening injuries, to provide expedited and definitive care, and to reduce and detect the complications predicted by these injuries and their treatment will result in long-term improvements in survival and significant reductions in morbidity.
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PMID:Pulmonary and respiratory complications of pediatric trauma. 1158 5

Salvage surgery is an essential method in the armamentarium of the surgeon caring for the severely injured patient. The patient in unstable condition with multiple abdominal injuries is a challenge, even to the most experienced trauma surgeon. The first priority should be to control major vascular injuries and other sources of bleeding that are immediately life-threatening. Often after massive blood loss, the deadly triad of hypothermia, acidosis, and coagulopathy is present. Additional time in the operating room often worsens these physiologic parameters and patient outcome. Once surgically correctable bleeding has been addressed, such patients are best served by cessation of the operation, packing of the abdomen, and transfer to the intensive care unit. Resuscitative steps should then be taken. Once the physiologic derangement has been corrected, the patient can undergo definitive operative procedures.
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PMID:Salvage surgery. 1159 57

The resuscitation of the massively bleeding patient may seem superficially to be successful once the patient's vital signs have stabilized. The restoration of stable vital signs, however, does not confirm two critical elements of a thorough physiologic resuscitation: that there is truly adequate delivery of oxygen to all tissue beds and that physiologic disturbances that may have occurred because of massive transfusion during the resuscitation process have resolved. With respect to the adequacy of oxygen delivery, the current clinical endpoints, including mixed venous oxygen saturation, cardiac output, and serum lactate, reflect global perfusion and not regional oxygenation. Of these global measures, serum lactate is currently the best indicator as to whether some circulatory beds remain inadequately perfused. Serum lactate should be followed, and, in the event that elevated levels persist, measures to augment oxygen delivery (e.g., increasing cardiac output, hemoglobin concentration, oxygen saturation) should be undertaken. Gastric tonometry provides a method for specific examination of the splanchnic circulation. The current measurement techniques, however, require steady-state conditions and make it impractical in many physiologically dynamic situations. The physiologic disturbances associated with massive resuscitation (e.g., hyperkalemia, hypocalcemia, hypomagnesemia, hypothermia) should be anticipated. Coagulation disturbances occur, especially when massive transfusion is accompanied by hypotension, hypothermia, or acidosis. Coagulation parameters should be measured with the loss of each one half of blood volume or after each 30-minute interval, whichever occurs first. Evaluation at blood volume intervals is relevant to the development of a strictly dilutional coagulopathy. The development of DIC, occurring because of tissue factor exposure or acidosis, however, is related more to the time lapsed than to the absolute volume lost or replaced.
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PMID:The massively bleeding patient. 1177 75

OBJECTIVE: To assess the anaesthetic aspects of liver transplantation. DESIGN: Retrospective study. SETTING: University teaching hospital, Hong Kong. PATIENTS: The first 55 patients who received liver transplantations between 5 October 1991 and 14 June 1997. MAIN OUTCOME MEASURES: The anaesthetic technique used; indications for liver transplantation and type of graft transplanted; survival rate; duration of anaesthesia and surgical starting time; intra-operative changes associated with major transfusion; frequency of hypothermia, coagulopathy, and reperfusion; frequency of use of cell saver devices, veno-venous bypass, and a rapid infusion system; and associated complications. RESULTS: All patients received general anaesthesia with rapid sequence induction. Most adult recipients had cirrhosis from various causes, whereas biliary atresia was the most common condition in the paediatric population. Both cadaveric and living-related liver transplantations were performed, and the overall 1-year survival rate of patients who received a transplantation before June 1996 was 85%. Veno-venous bypass was used in 84% of adults, but in none of the paediatric patients; a cell saver device was used for all adult patients and 92% of paediatric patients. All transplant recipients had acidosis, hypothermia, and hypotension during the operation. CONCLUSIONS: Liver transplantation is no longer experimental. It is the therapeutic option for patients with chronic liver failure. Good anaesthetic support is an essential element of a liver transplantation service.
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PMID:Anaesthesia for liver transplantation: experience at a teaching hospital. 1182 64

Extensive blood loss requires adequate volume replacement. However the infused volume cannot be adequately warmed especially when high infusion rates are necessary. Subsequently, hypothermia develops and results in hemodynamic instability and coagulopathy. The Rapid Infusion System (RIS) allows high infusion rates (up to 1.5 l/min) while at the same time guaranteeing sufficient warming. The efficacy of the RIS was investigated in 43 consecutive patients who required a massive transfusion. The average volume transfused in these patients was 31.7 +/- 4.5 l (minimum: 7.8 l; maximum: 165.3 l) which is equal to an average exchange of 6.4 times the circulating blood volume (maximum: 39.4 blood volumes). The replacement of such high blood volumes has not yet been published in a series of patients. Despite these high transfusion rates, the body core temperature was maintained at 35.85 +/- 0.1 degrees C. Only five patients had a body core temperature below 34 degrees C, all were trauma patients and four of these five patients already had a preoperative temperature below 34 degrees C. The mortality in this study was 28%, which is markedly reduced in comparison to previous publications although they all considered at patients with significantly less blood loss. Maintaining normothermia and normovolemia by the use of the RIS may explain the improved outcome.
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PMID:[Massive transfusion with the Rapid Infusion System. Its effect on core body temperature]. 1182 76

Deep hypothermic cardiopulmonary bypass with or without circulatory arrest has been used to facilitate the surgical repair of complex cerebrovascular lesions. The advantages of deep hypothermia have been tempered by the occurrence of coagulopathy that is associated with substantial morbidity and mortality. This study analyzed retrospectively the records of 13 patients who underwent cerebrovascular neurosurgery using deep hypothermic cardiopulmonary bypass with or without circulatory arrest during the period 1993 through 1999. All patients received the serine protease inhibitor aprotinin in an effort to avoid the development of a coagulopathy, defined as hemorrhage requiring reoperation. No patients developed postoperative intracranial hemorrhage. There was also no evidence of renal dysfunction, deep venous thrombosis, myocardial infarction, or pulmonary embolism. In conclusion, this study suggests that aprotinin may be beneficial to avoid the coagulopathy that is more likely to occur if deep hypothermic cardiopulmonary bypass with or without circulatory arrest is used for craniotomy without adverse effects on renal function or apparent thrombotic complications.
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PMID:Aprotinin and deep hypothermic cardiopulmonary bypass with or without circulatory arrest for craniotomy. 1190 94

Over the past 20 years, it has gradually become apparent that the results of prolonged and extensive surgical procedures performed on critically injured patients are often poor, even in experienced hands. The triad of hypothermia, coagulopathy, and metabolic acidosis effectively marks the limit of the patient's ability to cope with the physiological consequences of injury, and crossing this limit will frustrate even the most technically successful repair. These observations have led to the development of a new surgical strategy that sacrifices the completeness of immediate repair in order to adequately address the combined physiological impact of trauma and surgery. This approach is unfolded in three phases. During the initial operation, the surgeon carries out only the absolute minimum necessary to rapidly control exsanguination and prevent the spillage of intestinal contents and urine into the peritoneal cavity. Packing represents the traditional method for the management of major liver injuries. The second phase consists of secondary resuscitation in the intensive care unit, characterized by maximization of hemodynamics, correction of coagulopathy, rewarming, and complete ventilatory support. During the third phase, the intra-abdominal packing is removed and definitive repair of abdominal injuries is performed. The "damage control" concept has been shown to increase overall survival and is likely to modify the management of the critically injured patient.
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PMID:Damage control surgery: an alternative approach for the management of critically injured patients. 1199 2


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