Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cold-reactive proteins, such as cold agglutinins, cryoglobulins, and cryofibrinogens, are reversibly precipitates, or gel, upon exposure to cold temperatures. Cryoglobulins are usually not of importance, but under special conditions, such as surgical hypothermia, hyperviscosity and damage in microcirculation may occur in patients with high plasma concentration of cryoglobulins. Several groups have reported their efforts to reduce further the risks of surgical hypothermia in patients with cold agglutinins, but rarely in patients with cryoglobulins. A 57-year-old woman with thoracic aneurysm, requiring replacement of the ascending aorta and the aortic arch, had mixed cryoglobulinemia (cryocrit 29%) associated with rheumatoid arthritis. Steroids therapy and preoperative plasmapheresis were performed, and cryocrit levels were decreased until 0% before operation. Systemic hypothermia (25 degrees C), hemodilution techniques during cardiopulmonary bypass, and cold crystalloid cardioplegia were successfully employed, and no clinical evidence of microcirculation damage was posed after operation.
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PMID:[A successful case of thoracic aortic aneurysm with mixed cryoglobulinemia]. 150 3

Intra-articular and skin surface temperatures of the temporomandibular joint (TMJ) were investigated in 34 patients with rheumatoid arthritis (RA). History was taken, and a clinical examination of the stomatognathic system was performed. The intra-articular temperature measurement was made with a thermocouple inserted through a needle, and the skin surface measurement was made with a thermocouple lateral to the condylar pole. The intra-articular temperature was lower for 37% and higher for 30% of the patients, whereas skin surface temperature was lower for 18% and higher for 6%, compared with normal individuals. Intra-articular and skin surface temperatures were positively correlated, and the average difference between skin surface and intra-articular temperatures was 1.6 degrees C. The intra-articular temperature was most strongly and positively correlated to the number of joint regions affected by RA and negatively correlated to the number of tender masticatory muscles, whereas skin surface temperature was most strongly and positively correlated to room temperature and negatively correlated to the number of tender masticatory muscles. These results indicate that pain and tenderness of masticatory muscles in RA are associated with hypothermia of the TMJ.
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PMID:Intra-articular and skin surface temperature of the temporomandibular joint in patients with rheumatoid arthritis. 316 62

Temperature measurements were made on the skin surface over the masseter muscle in 71 individuals with rheumatoid arthritis (RA group) and in 52 individuals without general joint disease or symptoms (C group). The temperature recordings were performed with thermistors in contact with the skin. Symptoms in the stomatognathic system and general joint symptoms were investigated by means of a questionnaire. A clinical examination was made of the stomatognathic system. In addition, a medical examination including clinical articular indices and laboratory tests was made. The skin surface temperature over the masseter muscle was generally decreased for the individuals with RA compared with the C group but increased with duration of temporomandibular joint (TMJ) symptoms, approaching normal values. Duration was also the most important variable among those investigated in determining the skin surface temperature over the masseter muscle. Hypothermia in the RA group was correlated with craniomandibular disorders such as lateral deviation of the mandible on mouth opening and TMJ clicking, whereas individuals with a history of swelling in the TMJ region had a higher temperature than average in this group. The results of this study show that there is a correlation between craniomandibular disorders and decreased skin surface temperature over the masseter muscle in individuals with RA.
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PMID:Skin surface temperature over the masseter muscle in individuals with rheumatoid arthritis. 316 85

TMJ autopsy specimens were examined with tomography. The joint surfaces were examined for structural changes. The radiologic methods was evaluated for ability of detecting these changes. A microscopic examination was performed concerning form and position of the disc, and histological features of radiologic cysts, erosion and sclerosis. Symptom-free individuals and patients with rheumatoid arthritis were examined thermometrically. The patients were also examined radiologically. The sensitivity of tomography increased with severity and extent of the structural changes and was higher for changes localized to the condyle than the temporal component. In areas with radiologic cyst, erosion and sclerosis there were macroscopic lesions in the condyle, while the temporal component more often was intact. Macroscopic structural changes were correlated between right and left TM joints. Anterior disc position was associated with perforation of the posterior attachment of the disc. Severity of radiologic changes in individuals with RA is correlated to duration and severity of subjective symptoms and clinical signs from the joint. The intra-articular temperature range in RA patients is greater than in symptom-free individuals. Pain and tenderness of the TMJ and masticatory muscles are thereby associated with hypothermia of the TMJ.
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PMID:Morphologic, radiologic and thermometric assessment of degenerative and inflammatory temporomandibular joint disease. An autopsy and clinical study. 348 Jun 12

Urinary excretion of the post-translationally modified amino-acid 3-methylhistidine, derived from the contractile proteins actin and myosin, was measured in patients with conditions associated with nitrogen loss. The ratio of 3-methylhistidine:creatinine excretion, a measure of the fractional catabolic rate of myofibrillar protein was increased in severe injury, thyrotoxicosis, neoplastic disease, prednisolone administration, and sometimes Duchenne muscular dystrophy. In myxoedema, osteomalacia, and hypothermia the ratio was decreased; and starvation, elective operations, and rheumatoid arthritis had little effect. Provided that the diet is meat free, measurement of urinary 3-methylhistidine may provide useful information on the cause of protein loss.
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PMID:Clinical usefulness of urinary 3-methylhistidine excretion in indicating muscle protein breakdown. 678 20

Sickle cell disease is a rare entity for the European cardiac surgeon to encounter. Low oxygen tension, acidosis and hypothermia may induce sickling and pose a great risk in this population during open heart surgery. We report the management of a 57-year-old Greek woman with homozygous sickle cell disease and rheumatoid arthritis, who underwent preoperative partial exchange transfusion and subsequent mitral valve replacement and tricuspid valve repair at normothermia.
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PMID:Mitral valve replacement and tricuspid valve repair in a patient with sickle cell disease. 1820 Apr 71

There are a variety of causes of neck pain, including trauma and degenerative changes. The history of onset helps to direct evaluation, including the need for imaging or ancillary testing. Patterns of pain, weakness, and other specific physical examination findings also aid in diagnosis. Management of most soft tissue injuries involves early mobilization, whereas fractures are managed based on patterns of instability. Acute spinal cord injury requires emergent care, to include possible decompressive surgery. The role of hypothermia and corticosteroids in these patients remains unclear. Cervical radiculopathy (eg, disk herniation, arthritic changes) can be managed conservatively in most patients. Central cord compression, or myelopathy, often is overlooked but is a common condition among older patients. Although certain patients may benefit from surgery, many have a stable course or slow progression that can be managed nonsurgically. Rheumatoid arthritis can have significant effects on the cervical spine. Patients with inflammatory conditions may improve with steroids, nonsteroidal anti-inflammatory drugs, or biologic drugs, but these drugs rarely have lasting benefit in degenerative conditions. Stretching, strengthening, and other physical therapy modalities have been shown to be helpful for patients with chronic and acute but stable neck conditions.
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PMID:Spine Conditions: Cervical Spine Conditions. 2901 39