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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present a surgical case of 61-year-old man with distal aortic arch aneurysm. Under selective cerebral perfusion in deep hypothermia, we approached to the aneurysm through median sternotomy. Dilated distal aortic arch and proximal descending aorta with mural thrombus in the aneurysmal lumen were found. The aortic occlusion balloon catheter was inserted into the descending aorta. A Cooley woven Dacron graft (26 mm in diameter) was anastomosed at 5 cm above its distal end loosely to the descending aorta with five interrupted mattress sutures, and the distal portion of the graft was pushed down into the distal aorta ("elephant trunk" technique). Postoperative course was uneventful and the dead space around the graft in aneurysm was filled with thrombus. Six months later, however, emergent operation was performed because of compression of the bronchus and the esophagus by enlargement of the aneurysm due to leakage. The second operation was approached through 5th left intercostal thoracotomy and median sternotomy. The aneurysm was opened, and the thrombus was amounted to 500 g. The distal end of the graft was anastomosed end-to-end to the mid-portion of the descending thoracic aorta. Postoperative course was uneventful and the patient was discharged. It is concluded that Elephant trunk technique is effective and the postoperative control of hypertension is very important.
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PMID:[Surgical repair of distal aortic arch aneurysm using "elephant trunk" technique]. 156 45

Open distal anastomosis technique proposed by Cooley facilitates operative management of aortic dissection. Usually this procedure is performed under circulatory arrest, therefore, prolonged management is hazardous to cerebral and visceral organ systems. We have utilized profound hypothermia with total body retrograde perfusion: 1) myocardial protection through coronary sinus, 2) cerebral perfusion through superior vena cava with pretreatment of cerebral protective drugs, 3) abdominal visceral perfusion through inferior vena cava). We have obtained good results with this method in consecutive four patients with aortic dissection.
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PMID:[Clinical application of total body retrograde perfusion to aortic dissection operation]. 194 79

The present paper is dealing with cerebral irrigation aspects in three patients with vera polycythemia and 16 with Cooley's anaemia using the non-invasive rheoencephalographic method. The rheographic exploration was done with a 4-channel I.C.E. rheograph, being recorded on a B-channel Galileo multirecorder in parallel with the mathematical derivative of the wave and an EKG lead. The analysis of the rheographic parameter revealed that in patients with vera polycythemia there is an obvious venous stasis as well as important vasomotor tonus modifications induced by an affected blood viscosity. In patients with Cooley's anaemia, modifications in the cerebral irrigation are dominated by chronic anaemia; the latter causes chronic hypoxia of the whole body and a reduced cerebral irrigation due to a depressed cardiac volume and vasomotor tonus to the effect of hypothermia--explained through cerebral vascular self-regulation mechanisms. The investigated groups are interesting because their diseases are rare and severe; their cardiac performance was severely affected, with severe hemodynamic disturbances in the cerebral circulation, too.
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PMID:Rheographic vascular manifestations in some rare malignant hemopathies. 311 16

Cardiovascular surgical repair of arch aneurysms is taking a step forward by going backwards by utilizing retrograde cerebral perfusion. Drs ME DeBakey, ES Crawford, DA Cooley and GC Morris first reported successful resection and repair of a fusiform aneurysm of the aortic arch with replacement graft in 1957. Since then, Crawford and Coselli have pursued materials and techniques which have made this procedure, one which generally resulted in high morbidity and mortality, more viable with decreased morbidity and mortality. Increased numbers of patients are now having this repair and are resuming normal healthy lives after the operation. From February 1992 to October 1993, 88 patients were surgically treated by Coselli who utilized retrograde cerebral perfusion with profound hypothermia and circulatory arrest, thus allowing for repairs that under any other conditions probably could not have been achieved successfully. It is evident that a major determinant for the successful clinical results, in addition to surgical technique and skill, was the employment of profound hypothermia and circulatory arrest. This article will review the techniques and results of aortic arch repair utilizing retrograde cerebral perfusion during circulatory arrest with profound hypothermia to lessen the chance of neurological morbidity following surgical replacement of the transverse aortic arch.
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PMID:Retrograde cerebral perfusion: overview, techniques and results. 779 14

The duration of spinal cord ischemia is probably the most important single factor in the pathogenesis of paraplegia after repair of descending thoracic aortic aneurysms. We describe a modification of open distal anastomosis technique originally presented by Dr. Cooley, in which we use partial cardiopulmonary bypass with femoral cannulation and mild hypothermia. Cardiopulmonary bypass is interrupted after lowering patient's temperature to 32 degrees C and the aorta is clamped using one proximal clamp. During the suturing of the distal anastomosis blood is sucked to reservoire and returned oxygenated to the patient via the venous line using a shunt which is installed between the arterial and venous lines. After completion of the distal anastomosis the graft is clamped and cardiopulmonary bypass reinstituted. Rewarming is started as bleeding intercostal arteries are sutured and proximal anastomosis performed. This modification shortens the distal ischemia time, but supports the circulation of the kidneys and splanchnic area immediately after the distal anastomosis is finished. Lowering the temperature should give additional protection for the spinal cord and the blood can be returned oxygenated to the patient. In our opinion, this combination of femoro-femoral perfusion, mild hypothermia, and open distal anastomosis offers several benefits and can be used in dissections and aneurysms, which extend up to aortic hiatus.
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PMID:Open distal anastomosis in conjunction with partial cardiopulmonary bypass and mild hypothermia for repair of descending thoracic aortic aneurysms. 1066 25

Increased tolerance to cerebral ischemia produced by general anesthesia during temporary carotid occlusion. By B. A. Wells, A. S. Keats, and D. A. Cooley. Surgery 1963; 54:216-23. Local anesthesia with little or no preoperative sedation is currently recommended as the anesthetic of choice for temporary carotid occlusion during carotid endarterectomy. Purported advantages include minimal circulatory and respiratory changes from the local anesthetic, and constant verbal contact can be maintained with the patient so that neurologic changes are promptly recognized. However, local anesthesia may not be satisfactory in uncooperative or semiconscious patients. We therefore undertook a trial of general anesthesia in 56 consecutive patients undergoing carotid endarterectomy. Patients were induced in standardized fashion using intravenous thiopental (100-400 mg), atropine (0.2 mg), and succinylcholine (40-80 mg). Cyclopropane, along with deliberate hypercapnia and hypertension, was used for anesthesia maintenance. All patients tolerated carotid occlusion for periods of up to 30 min during general anesthesia without shunt, bypass, or hypothermia. Except for one patient, electroencephalogram evidence of cerebral ischemia was not apparent during occlusion, and no patient suffered postoperative neurologic sequela. Twenty percent of patients who had their carotid arteries occluded preoperatively for 30-60 s without general anesthesia suffered convulsions. These data suggest that general anesthesia increased the tolerance to cerebral ischemia. Potential mechanisms involved might include: 1) decreased cerebral metabolic rate for oxygen; 2) increased cerebral blood flow from hypercapnia; 3) increased arterial oxygen tension; and 4) recruitment of new routes of collateral circulation.
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PMID:Contributions of anesthesiology to the surgical treatment of cerebrovascular disease: the role of Arthur S. Keats, M.D. 1836 8

Depending on the extent of aortic disease and surgical repair required, thoracic aortic surgery often involves periods of reduced cerebral perfusion. Historically, this resulted in detrimental neurological dysfunction, and high risk of mortality and morbidity. Over the last half century, rapid improvements have revolutionized aortic surgery. Among these, deep hypothermic circulatory arrest (DHCA) has drastically reduced the risk of mortality and morbidity following surgery on the thoracic aorta. This progress was facilitated by experimental pioneers such as Bigelow, who studied reduced oxygen expenditure consequent on induction of hypothermia in dogs. These encouraging findings led to trials in human cardiac surgery by Lewis in 1952 and further made possible the first successful aortic arch replacement by Denton Cooley and Michael De Bakey. Modern day surgery has come a long way from the use of immersion of the patient in ice baths and other primitive techniques previously described. This paper explores the development of deep hypothermic circulatory arrest from its origins to the present.
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PMID:The History of Deep Hypothermic Circulatory Arrest in Thoracic Aortic Surgery. 2679 30