Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020639 (hypoproteinemia)
 1,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An intensive combination chemotherapy regimen supported by granulocyte colony-stimulating factor (G-CSF) was evaluated in 81-adult T-cell leukemia/lymphoma (ATLL) patients in a multi-institutional cooperative study. Complete remission and partial remission was achieved in 29 (35.8%) and 31 (38.3%) patients, respectively. The median survival of all patients was 8.5 months with a predicted 3 year survival of 13.5% by the Kaplan-Meier method. The median duration of response was 7.5 months and 13 patients are alive during a maximum observation period of 44.7 months. The median survival time was 29.1 months. Multivariate analysis using the proportional hazards model revealed hypoproteinemia, high GPT and thrombocytopenia as poor prognostic factors. In 42.5% of courses white blood cell (WBC) nadirs were less than 0.5 x 10(9)/l. Days required for the recovery of WBC from the nadir were less than 5 days in 64.2% of the treatment courses. The G-CSF-supported intensified chemotherapy regimen for ATLL yielded a better response rate and longer survival compared to previous reports in Japan. As duration of remission is still short, further studies of postremission therapy or other strategies are warranted.
 ...
PMID:[An intensive chemotherapy of adult T-cell leukemia/lymphoma]. 882 73

We report a case of ecthyma gangrenosum (EG) without septicemia in a renal transplant recipient who presented with a 1-month history of painful ulcers, vesicles and bullae on the face and extremities. Histopathological findings revealed subepidermal bullae covered by a necrotic epidermis containing an infiltrate of a moderate number of lymphocytes, neutrophils and necrotic collagen. Many dilated and congested capillaries were also present due to thrombi beneath the bullae, with alteration of collagen fibers through the superficial to middle dermis with some infiltrate. A culture from the ulcers revealed the presence of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus, whereas the results of repeated blood cultures were negative. The ulcers were completely cured by early appropriate i.v. antibiotic therapy with granulocyte colony-stimulating factor, without progression to EG with septicemia. An immunocompromised state due to immunosuppressive drugs, in addition to diabetes mellitus, hypogammaglobulinemia and hypoproteinemia, may have caused the EG and herpes zoster may have exacerbated the condition.
 ...
PMID:Ecthyma gangrenosum without pseudomonas septicemia in a kidney transplant recipient. 1883 4