Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020639 (
hypoproteinemia
)
1,134
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Drug binding to protein is known to be altered in renal disease. Explanations include
hypoproteinemia
, competitive or noncompetitive inhibition, and basic functional defects in the binding protein. Albumin, the primary binding protein for phenytoin (
DPH
), was isolated from the plasma of patients with severe renal failure as well as from normal controls.
DPH
binding was not different between the albumin preparations isolated from the two sources, although some differences were detected in the apparent affinity constant and the number of binding sites. It would appear that the significant defect in
DPH
binding in renal disease cannot be attributed to a basic functional defect in the drug-binding protein albumin.
...
PMID:Phenytoin binding to partially purified albumin in renal disease. 746 Apr 84
