Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020639 (hypoproteinemia)
 1,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Biological methods were employed to detect postburn changes of serum TNF activity and in vitro IL-1 production of blood monocytes in 24 severely burnt patients. The internal organ function represented by myocardial and hepatic enzymes and some indexes of systemic metabolism were simultaneously determined. The results showed marked increase of TNF activity and evident decrease of in vitro IL-1 production of monocytes, and that their changes were correlated well with those of myocardial and hepatic enzymes in MOF patients. Febrile reaction, hypoproteinemia and increased plasma lactic acid level suggested tissue hypoxia and hypoxemia and increased catabolism. These were more evident in MOF patients. The results indicated that TNF and IL-1 participated in the pathogenesis of MOF.
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PMID:[Relation between some cytokines and the severely postburn internal organ injury]. 831 97

Resveratrol (RES) is well known natural polyphenol with proven antioxidant, antiinflammatory and anticarcinogenic properties. Since mode of application may be important for cancer-preventive effects of RES, the aim of this study was to evaluate a possible delay in the initiation and progression of chemically induced mammary carcinogenesis in female Sprague-Dawley rats after the nocturnal administration of RES. Application of a high dose of RES (100 mg/kg body weight), starting 2 weeks before the first N-methyl-N-nitrosourea dose (NMU) (50 mg/kg body weight), reduced tumor incidence and markedly prolonged latency period (P < 0.01) in the NMU + RES group in comparison to NMU tumor bearing animals. In addition, the tumor volume decreased significantly (P < 0.05) together with tumor frequency (P < 0.05). We also observed that food but not water intake was significantly reduced by 17% between weeks 4 and 12 in the NMU + RES group leading to a pronounced reduction in the body mass of about 25% as compared to untreated controls. In addition to direct effects of RES in tumor tissues, this polyphenol did also improve metabolic functions in RES-treated animals since it normalizes hypoproteinemia and urea levels and increases the number of lymphocytes when compared with NMU. Higher level of reactive oxygen species (ROS) in leukocytes and the elevation of proinflammatory plasma cytokines IL-1 and IL-2 may contribute to the observed reduction in tumor development. These results indicate for the first time that nocturnal administration of a high dose of RES significantly affects tumor development in vivo. Therefore, we conclude that RES is a promising candidate for cancer chemoprevention. However, it should be noted that the mode of application might significantly affect RES ability to fight cancer.
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PMID:Nocturnal resveratrol administration inhibits chemically induced breast cancer formation in rats. 2955 Jul 99