Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020639 (hypoproteinemia)
 1,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experiments were performed to provide information on the mechanisms of the formation of gingival fluid in rats and on the determinants of its flow and composition. For this purpose we studied the effect of increasing net capillary filtration by venous stasis induced by multiple ligations of the jugular vein or by hypoproteinemia induced through puromycine nephrosis. A 1 microliter glass capillary was placed in the sulcus of the first maxillary molar for collection of gingival fluid (GF). Colloid osmotic pressure (COP) was determined in GF, in wick fluid from attached gingiva and buccal mucosa, and in plasma. Interstitial fluid hydrostatic pressure (Pi) was measured by micropuncture technique and the fractional removal rate of radio-labelled human serum albumin (kAlb) was recorded in attached gingiva and buccal mucosa. During venous stasis the gingival fluid flow increased from 1.7 microliters/h to 3.8 microliters/h, whereas COPGF fell from 14.1 mmHg to 8.8 mmHg. COP in wick fluid from gingiva was reduced from 10.3 to 4.3 mmHg. Pi increased from 6.8 to 13.1 mmHg, and kAlb in sham-operated controls increased from 0.068 to 0.189 h-1. In buccal mucosa COPi was significantly decreased to 7.1 mmHg in rats with venous stasis, whereas Pi and kAlb remained unchanged compared to the sham-operated controls. In hypoproteinemic rats COPGF was 5.0 mmHg and COPp was reduced from 18.9 to 8.0 mmHg. COPi declined from 8.9 mmHg to 2.4 mmHg in gingiva and from 8.1 mmHg to 2.7 mmHg in buccal mucosa.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Effect of venous stasis and hypoproteinemia in gingival fluid formation in rats. 756 18

A 1.5 year old neutered male pet ferret (Mustela putorius furo) was presented with a sudden onset of severe weakness. The ferret was kept with three healthy mates, was vaccinated against distemper regularly and was never ill before presentation. Clinically, the ferret was depressed, had a hyperthermia of 40.3 degrees C, tachypnea and ocular as well as nasal discharge. Blood work revealed a mild neutropenia, blood chemistry a hyperglycemia, hyperbilirubinemia, hypoproteinemia, hypoalbuminemia, hypocalcemia and hyponatremia. Despite intensive therapy including fluid replacement, antibiosis, analgesia and antipyretics, the overall condition of the ferret deteriorated and the animal was euthanized two days later. Necropsy revealed a pyogranulomatous myositis, fasciitis and steatitis of the long hyoid muscles, the esophagus and intestine. Lesions were consistent with the disseminated idiopathic myositis of ferrets. This is the first reported case of this disease in a ferret originated in Germany.
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PMID:[The first report of a disseminated idiopathic myofasciitis in a ferret (Mustela putorius furo) from Germany]. 2587 87