Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020639 (hypoproteinemia)
 1,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nephrotoxicity of daunorubicin in rats and effect of tocopherol and ascorbic acid on lesions induced in kidneys by daunorubicin were examined. Daunorubicin induced nephrotic syndrome with proteinuria and hypoproteinemia. Histological changes in the glomeruli appeared as a dilatation of capillary loops and enlargement of the urinary space. The glomerular basement membrane showed minimal thickening. In tubuli protein casts were noticed. No beneficial influence of tocopherol and ascorbic acid on daunorubicin related nephrotoxicity was observed.
 ...
PMID:[Evaluation of daunorubicin nephrotoxicity and effect of tocopherol and ascorbic acid on lesions induced in rat kidneys. I. Histologic, histochemical and biochemical studies]. 853 55