Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020639 (hypoproteinemia)
 1,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pseudomembranous enterocolitis is reported in five children. The clinical syndrome, characterized by the acute onset of profuse diarrhea, occurred postoperatively in 2 patients. All the patients had received or were taking antibiotics (penicillin, ampicillin, clindamycin). The disease was severe in 4 persons who presented with hypoproteinemia. Related complications were edema, ascites, pleural effusion, septicemia and/or shock. The diagnosis was made on the basis of typical rectosigmoidoscopic findings. Despite intensive therapy 2 children died. The use of parenteral nutrition is advocated in severe cases with exudative enteropathy. When profuse diarrhea occurs postoperatively or does not rapidly subside with discontinuation of antibiotic therapy, a high index of suspicion should be maintained, even in children, for the possibility of pseudomembranous enterocolitis. An emergency rectosigmoidoscopy should be done in order to make an early diagnosis.
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PMID:Pseudomembranous enterocolitis in childhood. 40 21

The nephrotic syndrome is characterized by gross proteinuria, hypoproteinemia, hyperlipemia, and edema. The authors review the diagnostic features and management protocol of this syndrome in children.
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PMID:Nephrotic syndrome in childhood: diagnosis and management. 41 35

For 37--48 days the action of qualitatively different proteins (caseine jellatine) on some factors of the immunobiological reactivity of growing albino rats of the Wistar lineage was studied. A decline of the body mass and hypoproteinemia maintained on a diet with jellatine by comparison with animals with corresponding factors receiving caseine was revealed. In the spleen, mesenteric lymph nodes and in the small intestine layer proper in rats given a diet with jellatine a reduced number of plasmatic cells and also of the lymphoid series in the epithelial layer of the small intestine villi was disclosed. These animals failed to demonstrate the presence of specific antibodies 3 weeks after immunization with diphtherial anatoxin, whereas the heterohemagglutinines titre was rising. In animals kept on a diet with caseine the proportion of the heterohemagglutinines production and of specific antibodies had a reciprocal character, which manifested itself in a hefty depression of the agglutinines biosynthesis to sheep erythrocytes with an accruing titres of antidiphtherial antibodies.
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PMID:[Action of qualitatively varied proteins in the ration on aspects of the immunobiological reactivity of the body of white rats]. 43 31

A case of Cronkhite-Canada syndrome is presented. The patient had alopecia, onychodystrophy and gastrointestinal polyposis, mainly in the stomach and duodenum, with transient diarrhea and hypoproteinemia. Marked atrophy and weakness of the shoulder girdle muscles due to myopathy were also present. In addition she had primary hypothyroidism. The outcome of the disease is usually fatal within months, but so far our patient is alive four years after the onset of symptoms. The pathological changes, pathophysiology, symptoms, course and treatment of this rare disorder of unknown etiology are discussed.
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PMID:A patient with Cronkhite-Canada syndrome, myxedema and muscle atrophy. 43 75

Although it is well known that growth hormone may influence protein metabolism, few investigations have been undertaken on serum protein levels in acromegaly; recently hypoglobulinemia has been observed in this endocrine disorder. In 28 acromegalic patients and 56 control subjects sera have been analyzed for total protein determination and for electrophoretic protein separation. The results have shown that in acromegalic there is a slight but statistically highly significant decrease of serum total protein (mean +/- SE 6.66 +/- 0.07 g/100 ml vs 7.10 +/- 0.07 g/100 ml), albumin, alpha 1 and alpha 2-globulins. Since growth hormone stimulates protein synthesis, the pathophysiological significance of hypoproteinemia of acromegaly is at present obscure.
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PMID:Hypoproteinemia in acromegaly. 48 30

The pathogenesis of jejunoileal bypass-induced liver disease was investigated in the rat model. Male Sprague-Dawley rats were subjected to 90% jejunoileal bypass and compared to rats having undergone 90% jejunoileal resection, to ad libitum and pair-fed controls and to weight-matched (underfed) controls. After 8 weeks the animals were killed and selected analyses performed. Several indications of liver dysfunction were observed in the bypass rats including hepatomegaly, hypotriglyceridemia, hypoproteinemia, elevated SGOT levels, and markedly decreased levels of cytochrome P-450. All of these abnormalities with the exception of elevated SGOT levels and decreased serum proteins were not observed to the same degree in animals in which the defunctionalized bowel was resected. Rats which were underfed (weight matched) did not develop any of the abnormalities of liver injury demonstrated in the bypass rats. Multiple factors appear to be responsible for the production of bypass-induced liver disease, but the defunctionalized bowel plays an important role.
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PMID:Role of defunctionalized bowel in jejunoileal bypass-induced liver disease in rats. 51 91

A 5-month-old infant presented with vomiting and severe hypoproteinemia from exsudation of proteins into the digestive tract, confirmed by isotopic tests. The association of hypertrophic edematous gastritis, interstitial jejunitis, and severe blood eosinophilia suggested the diagnosis of an exsudative eosinophil-type gastro-enteropathy. An allergy to cow's milk proteins was suspected because of the onset of the disorders at the time of weaning and the appearance of the eczema during the same period. Clinical, biological, and radiological recovery occurred after an exclusion diet and corticotherapy, and this persisted for 8 months, but the eczema remained. The authors describe a similar case (12) in an infant of 21 months with vomiting edema, and hypoproteinemia due to exsudation of proteins into the digestive tract. Radiological examination revealed the presence of hypertrophic gastritis. A relationship with Mentrier's disease had been suggested but not confirmed because of the rapid favourable outcome after a simple low protein diet.
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PMID:[Hypertrophic gastritis in an infant with eczema and intolerance to cow's milk proteins (author's transl)]. 57 73

On the basis of recent pathophysiological data and clinical observations in three patients, this paper draws attention to the commonly neglected importance of postoperative hypoproteinemia as the cause of an edema of the intestinal wall with a consequent "interstitial" paralytic ileus. The characteristic features of this syndrome are its onset between the third and the eighth postoperative day; the absence of other known causes of intestinal hypomotility; the benign, but protracted course without treatment; and the therapeutic success achieved by the correction of a hypoproteinemic fluid overload with concentrated albumin and a diuretic. In addition, parenteral hyperalimentation and Rheomacrodex-Sorbit may be indicated, but the hypoproteinemia should at any rate be corrected.
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PMID:[Hypoproteinemia causing postoperative "interstitial" paralytic ileus]. 58 62

A 62-year-old woman with incapacitating atherosclerotic vascular occlusive disease was found to have severe hypoproteinemia as a result of Menetrier's disease. That diagnosis was suspected on roentgenographic and gastroscopic examinations and confirmed by examination of full-thickness surgical gastric biopsy specimens. The protein loss from the stomach was significantly decreased by treatment with trimethaphan and atropine and led us to perform proximal gastric vagotomy at the time of endarterectomy. Subsequent protein turnover studies suggest that there has been a significant decrease in protein loss by the stomach. Further evaluation of the possible role of medical and surgical vagotomy in this disease seems warranted.
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PMID:Menetrier's disease. Effect of medical and surgical vagotomy. 60 91

Chronic granulomatous enteritis associated with weight loss and hypoproteinemia was identified in 2 horses. Both horses continued to have normally formed feces. Malabsorption of carbohydrate and lipid, with concomitant gastrointestinal protein loss was demonstrated in 1 case. One horse was treated symptomatically and gained 108 kg. In both cases, principal gastrointestinal lesions were partial to total villus atrophy and transmural mononuclear leukocytosis, with lymphocytes and histiocytes predominating. The cause of the condition was not identified in either case.
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PMID:Chronic enteritis associated with the malabsorption and protein-losing enteropathy in the horse. 62 Nov 80


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