Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020639 (hypoproteinemia)
 1,134 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of Cronkhite-Canada syndrome is presented. The patient had alopecia, onychodystrophy and gastrointestinal polyposis, mainly in the stomach and duodenum, with transient diarrhea and hypoproteinemia. Marked atrophy and weakness of the shoulder girdle muscles due to myopathy were also present. In addition she had primary hypothyroidism. The outcome of the disease is usually fatal within months, but so far our patient is alive four years after the onset of symptoms. The pathological changes, pathophysiology, symptoms, course and treatment of this rare disorder of unknown etiology are discussed.
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PMID:A patient with Cronkhite-Canada syndrome, myxedema and muscle atrophy. 43 75

An elderly man with non-familial gastrointestinal polyposis, malabsorption and progressive hypoproteinemia is reported. Associated alopecia, cutaneous hyperpigmentation and nail dystrophy with loss of nails were consistent with the diagnosis of Cronkhite-Canada syndrome. Hypothyroidism was present in this patient and the rare association of these two conditions is discussed.
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PMID:Cronkhite-Canada syndrome with hypothyroidism. 237 35

We report about a 76 years old patient with Cronkhite-Canada syndrome. The diagnosis has been found with the following clinical symptoms: diarrhea, anorexia, alopecia, and onychotrophia. Laboratory values: severe hypoproteinemia (total serum protein 4.3 g/dl, albumin 2.4 g/dl); endoscopical and radiological findings: a generalized polyposis which involved the whole intestine except the oesophagus. As far as we saw in our literature-overview of 55 patients with Cronkhite-Canada syndrome, this patient had for the first time a carcinoma of the urinary bladder and a Bricker operation 17 years before the onset of his disease. Further we remarked a lack in the resorption of the enterally administered thyroidal hormones. The progress was fatal despite a parenteral hyperalimentation and a treatment with antibiotics and glucocorticoids.
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PMID:[New observations in a case of Cronkhite-Canada syndrome]. 396 97

We report a case of juvenile polyposis coli in a 13 year old girl who initially complained of rectal bleeding and prolapse of polyps. Tube feeding with an elemental or a low residue diet and total parenteral nutrition were prescribed to treat the hypoproteinemia and anemia. A modified Soave's operation was successfully performed. The polyps appeared in several different stages of development. A single dilated gland of the colonic mucosa, which was not grossly visible, was presumed to be the site of the initial lesion which developed into a typical juvenile polyp. Adenomatous tubules were found in some juvenile polyps. In this case of immunologic deficiency, it is not clear whether such was a primary or secondary phenomenon.
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PMID:Juvenile polyposis coli. A case report. 712 Jul 7

Juvenile polyps are generally considered to have no malignant potential. We report a 16-year old patients with juvenile polyposis coli who presented with diarrhea and hypoproteinemia. Some of her polyps had adenomatous histologic features and a large villoglandular polyp was present in the cecum. The usual nonoperative management of patients with juvenile polyposis may not be appropriate when the polyps show mixed histology. These patients are at risk to develop malignancy although the magnitude of risk is uncertain.
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PMID:Multiple adenomas in juvenile polyposis. 727 May 31

Assays were made of blood serum proteins, final nitrogen products of urine and faeces in 115 patients with colonic cancer and in 19 patients with polyposis. The nitrogen balance was studied in 59 rectal cancer patients prior to and after the operation. In a group of patients with the malignant tumor the endogenic protein hyperexcretion was found as well as a reduced serum proteins level and an associated dependence of hypoproteinemia on the degree of their loss with faeces. A negative nitrogen balance was noted in patients with cancer. Surgical intervention, purulent infection may aggravate this condition. The radical treatment of colonic cancer results in a gradual normalization of nitrogen-protein metabolism.
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PMID:[Causes of a nitrogen balance disorder in patients with cancer of the large intestine]. 743 79

Colon polyps are very common in infancy, most cases are unique, seldom exceeding ten; as a rule, the treatment is endoscopic resection. The AA present a case of a severe diffuse colorectal juvenile polyposis in an 8-year-old black child, with a 4-year evolution of serious digestive bleeding, abdominal pains, anemia and hypoproteinemia. The disease scattered throughout the colon with a great density at the rectum and sigmoid level, coating fully the mucous membrane, making the classic treatment by endoscope unworkable. A resection of the rectum and descendent colon with transrectal pullthrough by the Soave technique with anal demucosization was performed. The post operative without incidents and the follow-up period was considered satisfactory. Complementary endoscopic resection of the remaining and scattered polyps followed. The result of the histopathological examination of all elements studied was juvenile polyps. This case demonstrates the necessity of surgical treatment with resection in cases of severe diffuse juvenile polyposis, in which endoscopic resection alone is not deemed to be sufficient.
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PMID:[Colorectal prolapse in a child with a severe form of juvenile polyposis]. 765 93

Cap polyposis is a rare intestinal disease that can be difficult to differentiate from inflammatory bowel disease. When cap polyposis is suspected, it is important to confirm protein loss. A 54-year-old woman who had been treated for ulcerative colitis for 7 years had severe hypoproteinemia. Scintigraphy with Tc-99m-labeled DTPA complexed with human serum albumin showed protein loss from the descending colon. Left hemicolectomy and sigmoid colectomy were performed. Cap polyposis was diagnosed on the basis of histologic findings from an operative specimen. The patient's diarrhea resolved after surgery and her hypoproteinemia improved. Scintigraphy with this label gave information helpful in the diagnosis of cap polyposis.
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PMID:A case of cap polyposis investigated by scintigraphy with human serum albumin labeled with Tc-99m DTPA. 971 85

The pathogenesis of cap polyposis remains unknown. Here, we report a patient with cap polyposis that developed simultaneously in the colon and stomach, and which regressed after Helicobacter pylori eradication. A 63-year-old man was diagnosed as having cap polyposis with mucoid stool, diarrhea, and bleeding on defecation. Following 5 weeks of total parenteral nutrition, his symptoms and hypoproteinemia improved and he was discharged, although follow-up colonoscopic findings revealed no improvement. Subsequent gastroscopy revealed diffusely erosive polyps with cap-like "fur" from the angle to the antrum of the stomach, similar to the lesions observed in the colon. Because H. pylori infection was demonstrated in the stomach, eradication therapy was administered. After this treatment, his symptoms immediately disappeared, and the polypoid lesions in the colon and stomach had completely disappeared 8 months later. Because there have been no previous reports of a relationship between H. pylori and cap polyposis, this case is of great interest.
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PMID:Cap polyposis cured by Helicobacter pylori eradication therapy. 1210 81

We describe a case of Cronkhite-Canada syndrome associated with sigmoid colon cancer, and provide a literature review. A 77-year-old man was diagnosed with sigmoid colon cancer after presenting with hypoproteinemia, nail atrophy, loss of scalp hair, hyperpigmentation, and gastrointestinal polyposis. The findings were consistent with Cronkhite-Canada syndrome. The colon polyps were histologically serrated adenomas, whose crypts showed a saw-toothed growth pattern with dysplasia, or tubular adenoma. Cronkhite-Canada syndrome associated with colon cancer has been reported in 31 cases. The availability of histologic material permitted reexamination of 25 of these cases. Serrated adenoma of the polypoid lesions was retrospectively found in 10 (40%) of the 25 cases. By comparison, the incidence of serrated adenomas has been estimated to occur in about 1% of all general polyps. Taken together, it is suggested that Cronkhite-Canada syndrome associated with colorectal cancer frequently has polyps containing serrated adenoma lesions. In the case described here, microsatellite instability and overexpression of the p53 protein were found in the cancer lesion and serrated adenoma lesions, and none of the lesions showed a loss of heterozygosity of various genes or K-RAS mutations. Thus, genetic alterations between the serrated adenoma and the colorectal cancer was correlated in this case. These findings suggested the possibility of a serrated adenoma-carcinoma sequence in this case of Cronkhite-Canada syndrome.
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PMID:Cronkhite-Canada syndrome containing colon cancer and serrated adenoma lesions. 1594 6


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