Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
170,190 document(s) hit in 31,850,051 MEDLINE articles (0.12 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
renin 12153
Sep 10407
insulin 9659
angiotensin II 7063
Ang II 3397
Mol 2903
calcium channel 2503
ACE 2161
albumin 2068
HDL 2061
collagen 1874
nitric oxide synthase 1857
She 1665
angiotensin receptor 1474
chronic renal failure 1443
hemoglobin 1434
MRI 1248
C-reactive protein 1235
endothelin-1 1175
SBP 1137
vasopressin 1090
bradykinin 1073
angiotensin II receptor 1068
angiotensinogen 1028
DBP 969
AT1 969
cytokine 913
mineralocorticoid receptor 905
leptin 893
ATPase 889
Pol 883
natriuretic peptide 859
Mal 840
fibrinogen 825
ATP 788
atrial natriuretic peptide 775
superoxide dismutase 729
Angiotensin-converting enzyme 725
vascular endothelial growth factor 668
ANG 652
tumor necrosis factor 635
endothelial nitric oxide synthase 634
Renin 626
tyrosine kinase 619
adiponectin 618
ACTH 614
phosphodiesterase 594
vascular endothelium 558
cyclooxygenase 519
TNF 518
gut 516
GFR 501
endothelin receptor 499
erythropoietin 491
atrial natriuretic factor 476
IL-6 470
Men 469
kallikrein 450
ET-1 442
catalase 440
HBP 408
parathyroid hormone 399
interleukin-6 398
proximal tubule 396
eNOS 393
CSF 364
beta-endorphin 356
cytochrome P450 351
serum albumin 341
ANOVA 335
elastin 333
arginine vasopressin 329
thrombin 327
MAP 324
sodium channel 319
fibronectin 319
guanylate cyclase 319
Rho 318
CRP 312
reserved 305
more...
Disease
hypertension 170190
diabetes 30437
obesity 15328
stroke 12305
cardiovascular disease 12024
atherosclerosis 8522
heart failure 8321
essential hypertension 7254
renal disease 6714
myocardial infarction 6315
type 2 diabetes 5481
proteinuria 5429
dyslipidemia 5362
coronary artery disease 5225
metabolic syndrome 5145
cancer 4719
coronary heart disease 4386
hyperlipidemia 4271
ventricular hypertrophy 4217
preeclampsia 4128
renal failure 3670
myocardial ischemia 3519
congestive heart failure 3401
hypercholesterolemia 3399
heart disease 3093
tumor 2954
ischemia 2716
depression 2633
pulmonary hypertension 2611
vascular disease 2421
chronic renal failure 2312
hyperglycemia 2222
anemia 1883
glucose intolerance 1781
renal artery stenosis 1754
diabetic nephropathy 1589
dementia 1580
aldosteronism 1478
renal insufficiency 1466
hyperinsulinemia 1442
obstructive sleep apnea 1436
pheochromocytoma 1396
microalbuminuria 1356
acute myocardial infarction 1344
glomerulosclerosis 1263
asthma 1238
Alzheimer's disease 1223
cardiomyopathy 1195
NAME 1179
chronic obstructive pulmonary disease 1117
systemic lupus erythematosus 1085
sleep apnea 1067
glomerulonephritis 1029
systolic hypertension 1029
chronic disease 993
retinopathy 984
plaque 976
ATM 973
abdominal obesity 913
secondary hypertension 908
osteoporosis 902
arteriosclerosis 901
cognitive impairment 898
cold 872
hyperuricemia 839
eclampsia 807
nephrotic syndrome 801
HIV 799
subarachnoid hemorrhage 789
encephalopathy 789
arthritis 773
SEM 741
Conn 734
adenoma 730
peripheral vascular disease 722
type 1 diabetes 700
renal impairment 696
sepsis 695
cirrhosis 692
Cushing's syndrome 680
more...
Symptom
overweight 3031
headache 2890
angina 2330
pain 2106
anesthesia 2037
seizures 1365
fatigue 1036
dyspnea 927
vomiting 809
nausea 784
chest pain 764
diarrhea 752
weakness 704
cough 671
abdominal pain 650
dizziness 649
sleepiness 496
syncope 407
respiratory distress 402
snoring 331
insomnia 318
hypothermia 301
hypercapnia 301
back pain 294
collapse 292
analgesia 286
flushing 274
discomfort 259
constipation 250
discomfort 248
spasm 242
agitation 228
shortness of breath 226
anorexia 207
oliguria 204
tremor 201
vertigo 198
polyuria 175
tinnitus 169
ataxia 169
nausea and vomiting 161
regurgitation 151
flank pain 143
myalgia 140
exertional dyspnea 134
hemiplegia 131
arthralgia 129
cyanosis 128
asthenia 126
dysarthria 125
Ill 123
thinning 122
lethargy 122
hemoptysis 121
paresis 114
tachypnea 114
blurred vision 114
exhaustion 110
polydipsia 107
numbness 104
functional recovery 100
paresthesia 92
hypocapnia 86
pallor 80
low back pain 80
masculinization 75
acute stress 74
epigastric pain 74
splenomegaly 70
Cushingoid 67
chills 66
Cushingoid 66
hepatomegaly 65
livedo 63
hyperoxia 63
dystonia 63
erythema 60
sinus pressure 52
leg edema 52
neck pain 52
more...
Drug
Cardiovasc 4808
Angiotensin II 1102
Nephron 619
Captopril 600
Dial 553
Monit 523
nitroglycerin 450
MAP 381
CSF 378
Nephron 358
Dermatol 335
caffeine 285
lysine 281
ascorbate 275
vitamin E 232
ETA 205
ROS 203
Clonidine 195
Atenolol 165
Indomethacin 153
Aliskiren 150
Valsartan 150
Bevacizumab 146
Ramipril 143
ROC 137
Ouabain 135
Bosentan 125
Bosentan 125
Hydrochlorothiazide 121
Perindopril 119
Nebivolol 110
PTH 107
Fructose 92
Isradipine 89
Olmesartan 88
Spectrum 86
Sodium nitroprusside 86
Nitric Oxide 84
NADH 84
Tacrolimus 82
Triclosan 78
Felodipine 77
Asthma 76
Albumin 76
ADM 73
EE2 71
ICI 70
Indapamide 68
Heme 67
ENT 66
CTX 62
Ethanol 61
Indapamide 61
niacin 61
Sorafenib 59
Leaf 59
Methyldopa 56
BH4 56
Coral 54
Dakar 53
Atropine 53
EPI 52
Cilazapril 52
MRC 51
EPA 50
Lacidipine 49
Amiloride 48
Simvastatin 48
Trandolapril 47
MgSO4 46
CaCl2 45
IL-2 45
Amiloride 45
Fenoldopam 43
Gel 43
Phentolamine 43
CaCl2 43
Estrogens 43
CaCl2 43
Viagra 42
more...
Enzyme
renin 12154
ACE 4185
NO synthase 1083
ATPase 971
mitogen-activated protein kinase 921
superoxide dismutase 858
NADPH oxidase 846
NADPH oxidase 656
ERK 618
protein kinase 602
phosphodiesterase 596
protein kinase C 577
kallikrein 529
catalase 500
guanylate cyclase 436
CD10 338
MAP 324
thrombin 319
calcineurin 309
alanine aminotransferase 302
tissue plasminogen activator 269
NOS 252
glutathione peroxidase 241
peroxidase 238
aspartate aminotransferase 235
PAH 235
PRA 235
alkaline phosphatase 220
focal adhesion kinase 214
creatine kinase 212
lactate dehydrogenase 208
11beta-hydroxysteroid dehydrogenase 208
luciferase 201
xanthine oxidase 199
phospholipase C 182
AMP-activated protein kinase 181
tyrosine hydroxylase 178
adenylate cyclase 151
CAD 148
CAD 148
CAD 148
angiotensin-converting enzyme 2 145
caspase-3 139
trypsin 139
HSD 139
monoamine oxidase 134
lipoprotein lipase 128
soluble epoxide hydrolase 127
gamma-glutamyl transpeptidase 125
phosphatidylinositol 3-kinase 124
MEK 118
phospholipase A2 116
heme oxygenase 116
proteasome 109
APC 109
thromboplastin 105
tissue kallikrein 104
reverse transcriptase 104
acetylcholinesterase 103
collagenase 102
AMPK 102
lipoxygenase 91
CYP3A4 89
AGT 88
ACS 86
AMPK 83
methylenetetrahydrofolate reductase 83
methylenetetrahydrofolate reductase 83
lipase 81
arginase 79
PKG 79
PDE 76
AST 74
urokinase-type plasminogen activator 72
chymase 70
GRK5 66
elastase 65
cholinesterase 65
glutathione reductase 64
pepsin 62
more...
Compound
Clin 15314
Dec 11839
sodium 10609
glucose 7895
salt 7470
calcium 7451
Cardiol 6307
aldosterone 6132
creatinine 4979
nitric oxide 4835
oxygen 4633
water 4627
potassium 3939
acetate 3486
arginine 2453
DNA 2017
Ang II 1982
Angiotensin II 1943
noradrenaline 1464
Insulin 1228
prostacyclin 1137
DBP 971
DBP 969
urea 959
phosphate 849
cGMP 799
ATP 791
His 769
ethanol 713
CO2 689
nitrogen 680
vitamin D 675
homocysteine 664
DOCA 644
Salt 624
ACTH 616
Sodium 591
nitrate 586
iron 584
Dial 556
tyrosine 541
TNF 518
hydrogen 517
cAMP 454
Cholesterol 451
Losartan 446
sodium chloride 442
mercury 434
Adrenal 428
zinc 410
sulfate 408
Nifedipine 380
lysine 367
MAP 353
ASA 345
5-HT 327
glutamate 324
serine 320
Optimal 286
caffeine 286
alanine 280
ADP 276
phosphorus 276
Pac 263
threonine 260
Enalapril 259
Norepinephrine 259
Cyclosporine 253
nicotinamide 249
ACh 248
PGE2 247
proline 246
cadmium 244
Propranolol 244
PAH 240
Mg2+ 240
cysteine 239
NADPH 239
AMP 238
NADPH 238
more...