Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
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Human Gene/Protein
Proprotein convertase subtilisin/kexin type 2 7.5
LOC100129150 7.5
lethal giant larvae homolog 2 (Drosophila) 7.5
ANKRD35 7.5
Parkin 2 7.5
Fibulin 2 7.5
ribosomal protein S4, Y-linked 1 7.5
kallikrein-related peptidase 9 7.5
Metaxin-2 7.5
Steroid 11-beta-hydroxylase 7.5
SH2B3 protein 7.5
PRKWNK4 7.5
STOX2 7.5
TIGD6 7.5
Kelch-like protein 3 7.5
C7orf50 7.5
HBP 7.5
C5orf23 7.5
MYEOV2 7.5
CAV3.2 7.5
ZNF554 7.5
TMEM109 7.5
TRDX 7.5
LNHR 7.5
Calcium/calmodulin-dependent protein kinase ID 7.5
ZNF227 7.5
COIII protein 7.5
neurofilament 3 7.5
ALG10B 7.5
FAM99A 7.5
interphotoreceptor matrix proteoglycan 1 7.5
sorting nexin 19 7.5
NR3C2 protein 7.5
FAM160A1 7.5
tubulin, beta 1 7.5
PLEKHH3 7.5
ASXL2 protein 7.5
C14orf68 7.5
FLJ20584 7.5
C2orf47 7.5
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Disease
NIDDM4 7.5
Acute lead nephropathy 7.5
ODG2 7.5
hypertension 7.5
kallikrein hypertension 7.5
HTNB 7.5
Retinal thrombosis 7.5
Uterine displacement 7.5
Arteriolar nephrosclerosis 7.5
Achard-Thiers syndrome 7.5
bradykinin hypertension 7.5
Deficiency of vitamin D3 7.5
Intervillous thrombosis 7.5
Drug-induced impotence 7.5
Post-capillary pulmonary hypertension 7.5
Bladder Paraganglioma 7.5
stage III adrenocortical cancer 7.5
Expanding aneurysm 7.5
Chronic nonspecific lung disease 7.5
Withdrawal hypertension 7.5
Transient hypertension of pregnancy 7.5
Renal tubular defect 7.5
Generalized arteriosclerosis 7.5
Iliac artery dissection 7.5
Peripapillary choroidal neovascular membrane 7.5
Apparent Mineralocorticoid Excess Syndrome 7.5
Graves' disease with thyrotoxic crisis 7.5
Other forms of heart disease 7.5
renoprival hypertension 7.5
Neonatal hypertension 7.5
Renal parenchymal disease 7.5
Hypertensive chronic kidney disease 7.5
Idiopathic (IPAH) 7.5
Secondary restless legs syndrome 7.5
Exogenous hyperlipemia 7.5
Low-renin essential hypertension 7.5
Arterial leg ulcer 7.5
NIDDM3 7.5
Aortic arteriosclerosis 7.5
Homozygous alpha thalassaemia 7.5
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Symptom
urological impairment 7.5
Acute lumbago 7.5
Antepartum eclampsia 7.5
High maternal weight gain 7.5
External compression headache 7.5
Metabolic symptoms 7.5
Toxic symptom 7.5
Malaise and fatigue 7.5
Abdominal bruit 7.0
Paroxysmal hypertension 6.7
Empty delta sign 6.5
Red face 6.5
Musculoskeletal tenderness 6.5
Moist rales 6.5
Multiple symptomatology 6.5
Pericardial knock 6.5
cardiovascular pain 6.5
Junctional escape beats 6.5
Mucosal hyperemia 6.0
swollen prostate 6.0
Bulging fontanelle 6.0
feeling feverish 6.0
Cushingoid 5.9
Cushingoid 5.8
respiratory pain 5.7
Persistent dry cough 5.7
cardiovascular disability 5.7
feeling of malaise 5.7
bilateral carotid bruits 5.5
Cardiovascular symptoms 5.3
Morning headache 5.2
Auspitz's sign 5.2
ear congestion 5.2
localized weakness 5.2
heaviness of the head 5.0
tactile hallucination 5.0
cardiovascular impairment 5.0
Pulsatile tinnitus 4.8
Medusa's head 4.7
Pre-existing disease 4.7
more...
Drug
Dilevalol hydrochloride 7.5
Pexeva 7.5
Barnidipine hydrochloride 7.5
Mexrenoate potassium 7.5
Ecromeximab 7.5
Nesiritide citrate 7.5
Innopran XL 7.5
Cynt 7.5
Octodrine 7.5
Guancydine 7.5
Arotinolol hydrochloride 7.5
Lycium bark 7.5
Accupril 7.1
Mefruside 7.1
INSPRA 7.0
Tasosartan 7.0
Guanadrel sulfate 7.0
Guanadrel 7.0
Tikosyn 7.0
Methyldopate 7.0
Aliskiren 6.7
Accupro 6.7
Omapatrilat 6.7
Aramine 6.7
Olmesartan Medoxomil 6.6
Lercanidipine 6.6
Aramine 6.5
Penbutolol sulfate 6.5
Norvasc 6.5
Tiodazosin 6.5
Posicor 6.5
8-Hydroxy-2'-Deoxyguanosine 6.5
Lemildipine 6.5
Teveten 6.5
Delivert 6.5
Carfentanil citrate 6.5
Treprostinil 6.5
Lotrel 6.5
Apresoline 6.4
Doca 6.4
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Enzyme
calpain C 7.5
flavonol-3-O-glucoside L-rhamnosyltransferase 7.5
ADAMTS13 endopeptidase 7.5
renin 6.0
ACE 5.4
11beta-hydroxysteroid dehydrogenase 4.9
DszB 4.8
steroid 11beta-hydroxylase 4.7
PRA 4.7
angiotensin-converting enzyme 2 4.7
dimethylarginine dimethylaminohydrolase 4.6
aminopeptidase A 4.5
AGT 4.4
prostasin 4.3
endothelin-converting enzyme 4.2
kallikrein 4.0
aliphatic nitrilase 4.0
tissue kallikrein 4.0
prostacyclin synthase 3.9
20beta-hydroxysteroid dehydrogenase 3.9
NADPH oxidase 3.8
NO synthase 3.7
desulfinase 3.6
NADPH oxidase 3.6
PGE2-9-ketoreductase 3.5
GRK5 3.5
soluble epoxide hydrolase 3.4
small monomeric GTPase 3.4
thromboxane synthase 3.4
biliverdin reductase 3.3
pantetheinase 3.3
PAH 3.3
chymase 3.3
guanylate cyclase 3.3
aspartyl aminopeptidase 3.3
alpha-aminoadipate aminotransferase 3.2
3-mercaptopyruvate sulfurtransferase 3.1
phenylethanolamine N-methyltransferase 3.1
PHT 3.1
MAP 3.0
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Compound
Coronarian 7.5
Vindorosine 7.5
Hydroxyethyl disulfide 7.5
C22H34O7 7.5
Quinapril hydrochloride 7.1
DOPA sulfate 7.0
Guanadrel 7.0
Eprosartan 6.7
1H-benzo[f]isoindole-1,3(2H)-dione 6.5
Epinephrine sulfate 6.5
4-tert-butylphenyl diphenyl phosphate 6.5
C10H15N 6.5
Thiazide 6.3
Fosinopril 6.3
Enalkiren 6.2
Ro 42-5892 6.2
18-Oxocortisol 6.2
Chlorthalidone 6.1
Candesartan cilexetil 6.1
Eplerenone 6.1
Labetalol 6.1
Doxazosin 6.1
Telmisartan 6.1
Perindopril 6.1
PIH 6.1
Quinapril 6.1
Moxonidine 6.1
Irbesartan 6.0
2,3,3-trichloroacrylamide 6.0
Pteryxin 6.0
Inuline 6.0
C10H12O3 6.0
Perindopril erbumine 6.0
F-26 6.0
Fluorohydrocortisone 6.0
Coleonol 6.0
Methylripariochromene A 6.0
DOCA 5.9
Amlodipine 5.9
Candesartan 5.9
more...