Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.07 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
renin 12153
Sep 10407
insulin 9659
angiotensin II 7063
Ang II 3397
Mol 2903
calcium channel 2503
ACE 2161
albumin 2068
HDL 2061
collagen 1874
nitric oxide synthase 1857
She 1665
angiotensin receptor 1474
chronic renal failure 1443
hemoglobin 1434
MRI 1248
C-reactive protein 1235
endothelin-1 1175
SBP 1137
vasopressin 1090
bradykinin 1073
angiotensin II receptor 1068
angiotensinogen 1028
DBP 969
AT1 969
cytokine 913
mineralocorticoid receptor 905
leptin 893
ATPase 889
Pol 883
natriuretic peptide 859
Mal 840
fibrinogen 825
ATP 788
atrial natriuretic peptide 775
superoxide dismutase 729
Angiotensin-converting enzyme 725
vascular endothelial growth factor 668
ANG 652
tumor necrosis factor 635
endothelial nitric oxide synthase 634
Renin 626
tyrosine kinase 619
adiponectin 618
ACTH 614
phosphodiesterase 594
vascular endothelium 558
cyclooxygenase 519
TNF 518
gut 516
GFR 501
endothelin receptor 499
erythropoietin 491
atrial natriuretic factor 476
IL-6 470
Men 469
kallikrein 450
ET-1 442
catalase 440
HBP 408
parathyroid hormone 399
interleukin-6 398
proximal tubule 396
eNOS 393
CSF 364
beta-endorphin 356
cytochrome P450 351
serum albumin 341
ANOVA 335
elastin 333
arginine vasopressin 329
thrombin 327
MAP 324
fibronectin 319
sodium channel 319
guanylate cyclase 319
Rho 318
CRP 312
reserved 305
HTN 304
endoplasmic reticulum 300
AT1R 299
plasminogen activator inhibitor-1 294
neutral endopeptidase 293
IgA 290
ERK1 288
collecting duct 286
growth hormone 285
calcineurin 281
ENaC 278
matrix metalloproteinase 275
SARS 272
inducible nitric oxide synthase 271
NIDDM 269
Endothelin-1 269
p38 268
peroxisome proliferator-activated receptor 265
CHD 263
tap 259
aldosterone synthase 252
AT2 250
VEGF 249
beta 1 249
Leptin 240
glutathione peroxidase 238
NADPH 238
CO2 237
PRA 235
PAH 235
urinary kallikrein 232
ETA 229
platelet-derived growth factor 229
Gen 228
MAPK 225
AMP 224
calcitonin 220
alkaline phosphatase 218
angiotensin-converting enzyme 2 218
ARB 217
CD4 216
apolipoprotein E 215
JAMA 213
mTOR 212
glucagon 212
ERK 212
CYP11B2 211
ACE2 210
ADP 208
PLA 206
reductase 204
ROS 203
peroxisome proliferator-activated receptor gamma 203
HSD2 203
COX-2 202
lipopolysaccharide 198
von Willebrand factor 197
prothrombin 195
myosin 195
5-hydroxytryptamine 192
TNF-alpha 191
calmodulin 191
heme oxygenase-1 191
cyclooxygenase-2 190
RhoA 190
GSH 189
HLA 189
xanthine oxidase 189
sodium pump 188
neuropeptide Y 188
tyrosine hydroxylase 187
angiotensin I-converting enzyme 187
apolipoprotein 187
tissue plasminogen activator 186
lactate dehydrogenase 184
COPD 183
ANP 183
caspase-3 182
adrenocorticotropic hormone 181
prolactin 180
more...
Disease
hypertension 170190
diabetes 30437
obesity 15328
stroke 12305
cardiovascular disease 12024
atherosclerosis 8522
heart failure 8321
essential hypertension 7254
renal disease 6714
myocardial infarction 6315
type 2 diabetes 5481
proteinuria 5429
dyslipidemia 5362
coronary artery disease 5225
metabolic syndrome 5145
cancer 4719
coronary heart disease 4386
hyperlipidemia 4271
ventricular hypertrophy 4217
preeclampsia 4128
renal failure 3670
myocardial ischemia 3519
congestive heart failure 3401
hypercholesterolemia 3399
heart disease 3093
tumor 2954
ischemia 2716
depression 2633
pulmonary hypertension 2611
vascular disease 2421
chronic renal failure 2312
hyperglycemia 2222
anemia 1883
glucose intolerance 1781
renal artery stenosis 1754
diabetic nephropathy 1589
dementia 1580
aldosteronism 1478
renal insufficiency 1466
hyperinsulinemia 1442
obstructive sleep apnea 1436
pheochromocytoma 1396
microalbuminuria 1356
acute myocardial infarction 1344
glomerulosclerosis 1263
asthma 1238
Alzheimer's disease 1223
cardiomyopathy 1195
NAME 1179
chronic obstructive pulmonary disease 1117
systemic lupus erythematosus 1085
sleep apnea 1067
glomerulonephritis 1029
systolic hypertension 1029
chronic disease 993
retinopathy 984
plaque 976
ATM 973
abdominal obesity 913
secondary hypertension 908
osteoporosis 902
arteriosclerosis 901
cognitive impairment 898
cold 872
hyperuricemia 839
eclampsia 807
nephrotic syndrome 801
HIV 799
encephalopathy 789
subarachnoid hemorrhage 789
arthritis 773
SEM 741
Conn 734
adenoma 730
peripheral vascular disease 722
type 1 diabetes 700
renal impairment 696
sepsis 695
cirrhosis 692
Cushing's syndrome 680
acute renal failure 675
pulmonary edema 669
dysplasia 668
gestational diabetes mellitus 655
cerebral infarction 645
sepsis 637
migraine 633
transient ischemic attack 627
cardiovascular risk factor 611
coma 597
vasculitis 596
thrombocytopenia 596
malignant hypertension 595
hydrocephalus 594
rheumatoid arthritis 589
West 579
liver disease 575
malnutrition 567
breast cancer 562
erectile dysfunction 561
gout 555
pneumonia 553
fatty liver 550
neuropathy 543
renal hypertension 540
lupus 535
cerebral ischemia 534
infectious diseases 532
hypothyroidism 508
epilepsy 501
glaucoma 494
PSS 492
aortic stenosis 462
carcinoma 459
lung disease 450
uremia 450
diabetic retinopathy 446
osteoarthritis 442
Endothelial dysfunction 441
genetic hypertension 441
polycystic kidney 432
hypoglycemia 428
renal cell carcinoma 428
hypertrophic cardiomyopathy 424
abortion 423
right heart failure 422
diastolic hypertension 422
Goldblatt 415
AIDS 410
fits 405
lupus 405
psychological stress 404
nephrosclerosis 400
Takayasu 391
urinary tract infection 389
hypertension in pregnancy 389
pulmonary embolism 387
borderline hypertension 384
dilated cardiomyopathy 384
metastases 379
nephritis 372
blindness 362
polycystic ovary syndrome 362
tuberculosis 360
SARS 359
confusion 356
valvular heart disease 355
white coat hypertension 352
hypertensive heart disease 346
IgA nephropathy 344
unstable angina 344
Proteinuria 340
Chronic kidney disease (CKD) 338
rash 338
hyperhomocysteinemia 337
Parkinson's disease 337
fluid overload 334
portal hypertension 332
pyelonephritis 331
prematurity 331
more...
Symptom
overweight 3031
headache 2890
angina 2330
pain 2106
anesthesia 2037
seizures 1365
fatigue 1036
dyspnea 927
vomiting 809
nausea 784
chest pain 764
diarrhea 752
weakness 704
cough 671
abdominal pain 650
dizziness 649
sleepiness 496
syncope 407
respiratory distress 402
snoring 331
insomnia 318
hypothermia 301
hypercapnia 301
back pain 294
collapse 292
analgesia 286
flushing 274
discomfort 259
constipation 250
discomfort 248
spasm 242
agitation 228
shortness of breath 226
anorexia 207
oliguria 204
tremor 201
vertigo 198
polyuria 175
tinnitus 169
ataxia 169
nausea and vomiting 161
regurgitation 151
flank pain 143
myalgia 140
exertional dyspnea 134
hemiplegia 131
arthralgia 129
cyanosis 128
asthenia 126
dysarthria 125
Ill 123
lethargy 122
thinning 122
hemoptysis 121
paresis 114
tachypnea 114
blurred vision 114
exhaustion 110
polydipsia 107
numbness 104
functional recovery 100
paresthesia 92
hypocapnia 86
low back pain 80
pallor 80
masculinization 75
acute stress 74
epigastric pain 74
splenomegaly 70
Cushingoid 67
chills 66
Cushingoid 66
hepatomegaly 65
livedo 63
dystonia 63
hyperoxia 63
erythema 60
sinus pressure 52
neck pain 52
leg edema 52
decreased appetite 50
memory loss 50
exertional angina 49
hypotonia 48
ophthalmoplegia 47
cachexia 47
tonic-clonic seizure 46
excessive sweating 45
hypoproteinemia 45
sore throat 43
myoclonus 42
starvation 42
hepatosplenomegaly 42
paraparesis 41
ENT 40
lightheadedness 40
spasticity 39
Depressive symptoms 39
leg pain 38
rales 38
consciousness disturbance 37
wheezing 36
hunger 36
muscle cramps 36
stigma 35
menopausal symptoms 35
cerebellar ataxia 35
dysuria 34
rhinorrhea 34
photophobia 34
night sweats 31
Sedation 31
orthopnea 31
eds 29
loin pain 29
renal colic 29
hoarseness 29
nasal congestion 28
apathy 28
CSR 28
hypertonia 28
pedal edema 27
Stiffness 27
forgetfulness 27
atypical chest pain 27
bone pain 26
acute abdomen 25
acute pain 25
colic 25
hot flashes 25
enuresis 24
abdominal discomfort 24
tingling 23
loss of taste 23
chest tightness 23
Multimorbidity 23
hot flushes 23
neuralgia 22
hypersomnia 22
chorea 22
productive cough 21
presyncope 21
chronic cough 21
stridor 21
tense 21
rigors 20
syncopal episodes 19
skin irritation 19
pelvic pain 19
knee pain 18
cardiovascular impairment 18
acidity 18
persistent cough 18
clubbing 17
sneezing 17
dysesthesia 17
alexithymia 16
Decreased activity 16
Welt 16
acute abdominal pain 16
more...
Drug
Cardiovasc 4808
Angiotensin II 1102
Nephron 619
Captopril 600
Dial 553
Monit 523
nitroglycerin 450
MAP 381
CSF 378
Nephron 358
Dermatol 335
caffeine 285
lysine 281
ascorbate 275
vitamin E 232
ETA 205
ROS 203
Clonidine 195
Atenolol 165
Indomethacin 153
Aliskiren 150
Valsartan 150
Bevacizumab 146
Ramipril 143
ROC 137
Ouabain 135
Bosentan 125
Bosentan 125
Hydrochlorothiazide 121
Perindopril 119
Nebivolol 110
PTH 107
Fructose 92
Isradipine 89
Olmesartan 88
Sodium nitroprusside 86
Spectrum 86
Nitric Oxide 84
NADH 84
Tacrolimus 82
Triclosan 78
Felodipine 77
Asthma 76
Albumin 76
ADM 73
EE2 71
ICI 70
Indapamide 68
Heme 67
ENT 66
CTX 62
Ethanol 61
niacin 61
Indapamide 61
Leaf 59
Sorafenib 59
Methyldopa 56
BH4 56
Coral 54
Dakar 53
Atropine 53
EPI 52
Cilazapril 52
MRC 51
EPA 50
Lacidipine 49
Simvastatin 48
Amiloride 48
Trandolapril 47
MgSO4 46
IL-2 45
CaCl2 45
Amiloride 45
CaCl2 43
CaCl2 43
Gel 43
Phentolamine 43
Estrogens 43
Fenoldopam 43
CVA 42
Viagra 42
Omapatrilat 41
Treprostinil 41
Fluorescein 39
Orlistat 38
Lacidipine 38
Propofol 37
Portal 37
Clopidogrel 36
Vitamin E 35
THF 35
CIA 34
Fluorescein 34
Glycyrrhiza 34
Reserpine 34
Enalaprilat 34
Enalaprilat 33
Rosiglitazone 32
Neoral 31
Lercanidipine 31
DMSA 31
Olmesartan medoxomil 30
Digitalis 29
ACT 29
Diurnal 29
Glucagon 29
Magnesium sulfate 28
Rosuvastatin 28
Asn 28
Bayer 28
Pravastatin 28
Norplant 28
Cilnidipine 27
ALA 27
Forskolin 26
Iloprost 26
Prednisone 25
Growth hormone 25
Growth hormone 24
Nadolol 24
Histamine 24
Ringer's solution 24
Spectrum 24
Fraction 24
Chlorothiazide 24
Vitamin A 24
Viagra 24
HCH 23
Amlodipine besylate 23
Losartan potassium 23
lactose 23
Cicletanine 23
IFN-gamma 23
NAG 22
Kenyan 22
TAC 22
Lovastatin 22
Inderal 21
Norvasc 21
Prednisolone 21
Enalapril maleate 21
Timolol 21
Check 21
CPR 21
ABC 20
Bifidobacterium 20
Imatinib 20
citric acid 20
Methylprednisolone 19
CTA 19
DDAVP 19
Isoptin 19
DDAVP 19
ampicillin 18
Ginseng 18
pyridoxal phosphate 17
Cilostazol 17
Glutathione 17
Azelnidipine 17
Guanethidine 17
more...
Enzyme
renin 12154
ACE 4185
NO synthase 1083
ATPase 971
mitogen-activated protein kinase 921
superoxide dismutase 858
NADPH oxidase 846
NADPH oxidase 656
ERK 618
protein kinase 602
phosphodiesterase 596
protein kinase C 577
kallikrein 529
catalase 500
guanylate cyclase 436
CD10 338
MAP 324
thrombin 319
calcineurin 309
alanine aminotransferase 302
tissue plasminogen activator 269
NOS 252
glutathione peroxidase 241
peroxidase 238
aspartate aminotransferase 235
PRA 235
PAH 235
alkaline phosphatase 220
focal adhesion kinase 214
creatine kinase 212
lactate dehydrogenase 208
11beta-hydroxysteroid dehydrogenase 208
luciferase 201
xanthine oxidase 199
phospholipase C 182
AMP-activated protein kinase 181
tyrosine hydroxylase 178
adenylate cyclase 151
CAD 148
CAD 148
CAD 148
angiotensin-converting enzyme 2 145
caspase-3 139
trypsin 139
HSD 139
monoamine oxidase 134
lipoprotein lipase 128
soluble epoxide hydrolase 127
gamma-glutamyl transpeptidase 125
phosphatidylinositol 3-kinase 124
MEK 118
heme oxygenase 116
phospholipase A2 116
APC 109
proteasome 109
thromboplastin 105
tissue kallikrein 104
reverse transcriptase 104
acetylcholinesterase 103
collagenase 102
AMPK 102
lipoxygenase 91
CYP3A4 89
AGT 88
ACS 86
AMPK 83
methylenetetrahydrofolate reductase 83
methylenetetrahydrofolate reductase 83
lipase 81
PKG 79
arginase 79
PDE 76
AST 74
urokinase-type plasminogen activator 72
chymase 70
GRK5 66
elastase 65
cholinesterase 65
glutathione reductase 64
pepsin 62
endothelin-converting enzyme 62
plasmin 61
glutathione S-transferase 58
RNase 56
RNase 56
protein phosphatase 2A 53
AOR 53
aminopeptidase A 52
MMP 49
P-glycoprotein 47
aldehyde dehydrogenase 47
carbonic anhydrase 47
succinate dehydrogenase 45
dopamine beta-hydroxylase 44
phosphoinositide 3-kinase 42
alpha-glucosidase 42
subtilisin 41
RNA polymerase 41
alcohol dehydrogenase 41
dimethylarginine dimethylaminohydrolase 41
glucose-6-phosphate dehydrogenase 40
uricase 40
PTA 39
complex I 39
myosin light chain kinase 38
CD13 36
matrix metalloproteinase 2 36
beta-galactosidase 36
paraoxonase 36
paraoxonase 35
CPT 35
dipeptidyl peptidase IV 35
PARP 35
furin 34
prostate-specific antigen 34
CaMKII 34
adenosine deaminase 33
adenosine deaminase 33
LPL 33
ADH 31
prostacyclin synthase 31
NADPH-diaphorase 31
thromboxane synthase 31
3-hydroxy-3-methylglutaryl coenzyme A reductase 30
5'-nucleotidase 29
xanthine dehydrogenase 29
aldehyde dehydrogenase 29
cytochrome oxidase 29
cathepsin D 29
aldehyde dehydrogenase 29
GSK 29
aldehyde dehydrogenase 29
aldehyde dehydrogenase 29
prostaglandin synthetase 28
aldose reductase 28
GRK2 28
phenylethanolamine N-methyltransferase 28
ceruloplasmin 27
caspase-1 27
lysyl oxidase 27
myosin ATPase 26
matrix metalloproteinase 9 26
thyroid peroxidase 26
chymotrypsin 25
CPT 25
endonuclease 25
calcium pump 24
acid phosphatase 24
CPT 24
phospholipase D 24
PDK1 23
15-lipoxygenase 23
CPR 23
ribonuclease 23
diacylglycerol kinase 23
ribonuclease 23
cholesterol acyltransferase 22
GTP cyclohydrolase I 22
PST 20
alpha-galactosidase 20
more...
Compound
Clin 15314
Dec 11839
sodium 10609
glucose 7895
salt 7470
calcium 7451
Cardiol 6307
aldosterone 6132
creatinine 4979
nitric oxide 4835
oxygen 4633
water 4627
potassium 3939
acetate 3486
arginine 2453
DNA 2017
Ang II 1982
Angiotensin II 1943
noradrenaline 1464
Insulin 1228
prostacyclin 1137
DBP 971
DBP 969
urea 959
phosphate 849
cGMP 799
ATP 791
His 769
ethanol 713
CO2 689
nitrogen 680
vitamin D 675
homocysteine 664
DOCA 644
Salt 624
ACTH 616
Sodium 591
nitrate 586
iron 584
Dial 556
tyrosine 541
TNF 518
hydrogen 517
cAMP 454
Cholesterol 451
Losartan 446
sodium chloride 442
mercury 434
Adrenal 428
zinc 410
sulfate 408
Nifedipine 380
lysine 367
MAP 353
ASA 345
5-HT 327
glutamate 324
serine 320
caffeine 286
Optimal 286
alanine 280
ADP 276
phosphorus 276
Pac 263
threonine 260
Enalapril 259
Norepinephrine 259
Cyclosporine 253
nicotinamide 249
ACh 248
PGE2 247
proline 246
Propranolol 244
cadmium 244
PAH 240
Mg2+ 240
cysteine 239
NADPH 239
AMP 238
NADPH 238
leucine 235
GMP 232
Propranolol 231
iodine 231
silver 225
methionine 221
Estrogen 218
Verapamil 217
galactose 213
ADP 213
Amlodipine 210
ADP 208
ETA 205
copper 200
GSH 200
GSH 200
Verapamil 195
Phe 187
Hydrochlorothiazide 187
Telmisartan 182
Vitamin D 182
Dopamine 177
Thiazide 176
Uric acid 170
GABA 169
BNP 166
Ile 165
GABA 160
Spironolactone 155
Diabetol 154
Retinal 154
Indomethacin 149
H2S 148
Labetalol 148
H2O2 147
Sildenafil 146
FK506 143
Diabetol 138
Ouabain 136
glycerol 136
Hydralazine 136
Estrogen 135
EDTA 135
Tempol 135
Prazosin 134
NAD 133
DOC 132
AHA 131
Carvedilol 130
EDTA 129
Candesartan 127
selenium 126
Isoproterenol 126
Metoprolol 126
methanol 125
tryptophan 122
superoxide radical 119
Gly 119
carbonate 118
Dexamethasone 117
PEG 117
Metformin 115
Metformin 115
TGR 115
Salix 114
PGE 113
Bradykinin 113
Metoprolol 112
Diltiazem 112
Diltiazem 112
TSH 111
Nicardipine 111
Cereb 110
NAD 109
N-acetylcysteine 108
Lead 107
Perindopril 106
Doxazosin 106
LPR 104
Phenylephrine 102
more...