Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The structure and function of transcription factors of higher plants was studied by isolating cDNA clones encoding a wheat sequence-specific DNA binding protein. A hexameric nucleotide motif, ACGTCA, is located upstream from the TATA box of several plant histone genes. It has been suggested that this motif is essential for efficient transcription of the wheat histone H3 gene. A wheat nuclear protein, HBP-1 (histone DNA binding protein-1), which specifically binds to the hexameric motif, has previously been identified as a putative transcription factor. A cDNA clone encoding HBP-1 has been isolated on the basis of specific binding of HBP-1 to the hexameric motif. The deduced amino acid sequence indicates that HBP-1 contains the leucine zipper motif, which represents a characteristic property of several eukaryotic transcription factors.
 ...
PMID:A protein that binds to a cis-acting element of wheat histone genes has a leucine zipper motif. 277 48

On a baseline survey of 4936 school children, age ranged from 6 to 16 years, 199 children with the systolic blood pressure (SBP) value equal or greater than 95-th percentiles for age and sex were chosen as the hypertensive group (HBP), and the same number of children with the SBP lower than 50-th percentiles were matched as the normotensive group (NBP). For both groups the intra-RBC and plasma Na and K content, three sequential nights 8-hour urinary Na, K and creatinine excretion, and an oral saline-load test were performed. The results show that: (1) The intra-RBC K in the HBP was lower than in NBP, 259 +/- 57 vs 291 +/- 78 mumol/g-protein, P less than 0.01. That in those with positive hypertensive family history (FH+) was lower than in those of negatives (FH-). The intra-RBC K content was correlated inversely with diastolic BP, r = -0.43, P less than 0.001. No correlation between intra-RBC Na and BP was found; (2) Plasma Na concentration in HBP was much lower than in NBP, 137.5 +/- 7.9 vs 142.6 +/- 6.9 mmol/L, P less than 0.001. No difference was found between FH+ and FH-; (3) Mean 8-hour urinary K excretion at night was lower in HBP than in NBP, 23.9 +/- 11.5 vs. 28.2 +/- 14.7 mmol/g-creatinine, P less than 0.01; (4) After a load of oral saline the 4-hour urinary Na excretion was significantly higher in HBP than in NBP, 39.5 +/- 29.1 vs 30.8 +/- 23.2 mmol, P less than 0.01. Of those children with FH-, the 4-hour Na excretion in HBP was higher than in NBP, 39.8 +/- 29.4 vs 29.3 +/- 21.5 mmol, P less than 0.001, but no significant difference was found between HBP and NBP in children with FH+. We believed that the above changes in electrolytes in the children with their BP at higher-level percentiles represent an abnormal relation between potassium and arterial BP in the early stage of hypertension, as well as the early compensatory natriuresis of the kidneys.
 ...
PMID:[Sodium and potassium in children with hypertension]. 279 85

Cardiopulmonary blood volume (CPBV) and plasma renin activity (PRA) were measured simultaneously in five normal subjects and six patients with essential hypertension studied in the following different conditions: supine position, head-down tilt, thigh-cuffs inflation. In each individual, a significant negative correlation (r > or = 0.95) was observed between CPBV and PRA. The slope of the relationship (delta PRA/delta CPBV) was used as an index of sensitivity of the neural control of renin release through cardiopulmonary receptors of the low pressure system. Simultaneously, the sensitivity index of the high pressure baroreflex system (HPB) was evaluated using bolus injections of phenylephrine. In normal subjects and patients with hypertension, the delta PRA/delta CPBV ratio and HBP were strongly correlated. Both indices were negatively correlated to age. It is suggested that the sensitivity of the neural control of renin release as well as the arterial baroreflex sensitivity are influenced by age, and possibly the inflexibility of the vascular system.
 ...
PMID:Cardiopulmonary blood volume and plasma renin activity in man: preliminary report. 285 86

A group of 350 migraineurs (87 male, 263 female) and 300 controls without migraine (104 male, 196 female) were questioned about occurrence, in parents, of the atherosclerosis-related diseases (ASRD) of diabetes mellitus (DM), hypertension (HBP), myocardial infarction (MI), and stroke as well as about recurrent severe headache (RSHA). Occurrence of DM, HBP, MI and stroke was compared for mothers and fathers of migraine vs. those of control subjects and no significant differences were found. The mothers and fathers were pooled and resegregated by presence or absence of RSHA and then occurrence of DM, HBP, MI and stroke again compared. For mothers there was increased occurrence of stroke and DM in the RSHA group but the differences were not significant. For RSHA fathers there was increased incidence of MI (p less than .10) and HBP (p less than .01). Aggregate occurrence of all ASRD was evaluated for RSHA vs. no-RSHA parents. ASRD occurred more frequently in the RSHA than in the no-RSHA parents (p less than .05). Breakdown by age showed that this occurred at all ages in men (p less than .05) but in women the difference was significant only under age 60 (p less than .05). This study suggests that RSHA, which is primarily migraine, may be a risk factor or a marker for occurrence of ASRD.
 ...
PMID:Headache as a risk factor in atherosclerosis-related diseases. 292 74

Technetium-99m galactosyl-neoglycoalbumin ( [Tc]NGA) is a radiolabeled ligand to hepatic binding protein, a receptor which resides at the plasma membrane of hepatocytes. This receptor-binding radiopharmaceutical and its kinetic model provide a noninvasive method for the assessment of liver function. Eighteen patients were studied: seven with hepatoma, eight with liver metastases, four with cirrhosis (two had concurrent hepatoma and one chronic active hepatitis), and one patient with acute fulminant non-A, non-B hepatitis. Technetium-99m NGA liver imaging provided anatomic information of diagnostic quality comparable to that obtained with other routine imaging modalities, including computed tomography, angiography, ultrasound, and [Tc]sulfur colloid scintigraphy. Kinetic modeling of dynamic [Tc]NGA data produced estimates of standardized hepatic blood flow, Q (hepatic blood flow divided by total blood volume), and hepatic binding protein concentration, [HBP]. Clinical correlation was by classical Child-Turcotte criteria (CTC). Significant rank correlation was obtained between [HBP] estimates and CTC scores (rs = -0.72, p = 0.001). This correlation supports the hypothesis that [HBP] is a measure of functional hepatocyte mass. The combination of decreased Q and markedly reduced [HBP] may have prognostic significance; all three patients with this combination died of hepatic failure within 6 wk of imaging.
 ...
PMID:Technetium-99m NGA functional hepatic imaging: preliminary clinical experience. 299 17

A nuclear protein(s), HBP-2, that binds to the upstream region of the wheat histone H4 gene was identified from a fractionated nuclear extract of wheat germ by DNase I footprinting. The DNase I-protected region contained the conserved nonameric motif, CATCCAACG. Cross-competition experiments that used the mobility shift assay showed that this nuclear protein(s) binds specifically to the upstream sequence that has been postulated to be a cis element of the wheat H3 gene. Our findings suggest that this DNA-binding protein(s) may be a trans-acting factor in the regulation of the transcription of wheat histone genes.
 ...
PMID:DNA-binding protein(s) interacts with a conserved nonameric sequence in the upstream regions of wheat histone genes. 318 34

We report the clinical and biological picture of 34 primary hyperparathyroidism (PHT) cases, diagnosed in rheumatology. It concerned 25 women and 9 men, aged 61 + 11 years. The PHT was often asymptomatic (47 p. cent of cases) at the time of diagnosis. The clinical manifestations were dominated by asthenia (50 p. cent) and renal lithiasis (47 p. cent). We found a chondrocalcinosis in 29 p. cent of patients. No patient presented any bony manifestations of cystic osteitis; 7 out of 34 patients (including 6 women between 57 and 74 years) presented vertebral compression. The mean calcemia was 117 +/- 9 mg/l. There were no hypercalcemic attack. The dosage of PTH and cyclic AMP were elevated in 29 out of 32 and 28 out of 31 patients respectively. In all patients, the level of either of these two tests was increased. The chloremia/phosphoremia ratio was also extremely predictive of HBP, since it was increased, exceeding 3.3 in 33 out of 34 patients. The 25-hydroxyvitamin D levels (25 (OH) D) were normal. The levels of 1,25 (OH) 2D were markedly spread (37 +/- 16 pg/ml) and not significantly different from the reference group. Patients with lithiasis did not present a higher level of 1,25 (OH) 2D. A bone histomorphometry carried out in 15 patients showed a bone trabecular volume similar to that of the reference with the same age. The osteoclastic resorption was increased in all cases and was not correlated with the PTH level, but was significantly correlated with the level of 1,25 (OH) 2D (r = 0.79 p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Primary hyperparathyroidism seen in rheumatology. Clinical symptoms and the relation between bone histologic signs and biological parameters]. 326 11

An increased maternal plasma volume (PV) is a characteristic phenomenon of normal pregnancy, which may be related to a physiological decrease of peripheral resistances. The authors have studied the plasma volume of 1,105 patients distributed as follows: normal (387), permanently hypertensive patients (84), hypertensive patients during pregnancy (390), patients with apparently isolated RCIU (154) or with a pathological past-history during previous pregnancies (90). It appears that the PV is a sign of a severe HBP, and presents a rather early and good predictive value regarding the weight of the fetus and some complications such as severe UCIU and fetal death in utero. In case of pathological past events or pre-existing hypertension, the PV enables to differentiate rather well patients who will be prone to a complicated pregnancy. In view of these results, utilization and interpretation criteria of this parameter during pregnancies with hypertension or pregnancies in which there is a suspicion or a risk of intra-uterine growth delay, are defined.
 ...
PMID:[Measurement of maternal plasma volume during pregnancy]. 336 75

Arterial hypertension in blacks seems to present a few peculiarities in comparison to that of caucasians, whether it is from the epidemiological point of view: greater frequency of the disease, more severe prognosis; from the physiopathological point of view with especially a definite prevalence of HBP with low renin and inflation of the plasma volume and increased tendency to sodium retention, or finally from the therapeutic point of view, since randomized studies have demonstrated that black patients respond better to diuretics than to beta-blockers. Currently, it is impossible to explain these differences in a simple fashion: is it a genetic factor or, on the contrary, environmental factors? Perhaps the response lies between those two extremes.
 ...
PMID:[Arterial hypertension in black patients]. 354 67

The galactophilic lectin expressed on the surface of cultured Hodgkin's cells, recently described by this laboratory, has binding characteristics similar to those of the hepatic asialoglycoprotein receptor (HBP), and has been recognized as a Mr 55,000 (p55) membrane glycoprotein by a polyclonal antiserum to rat HBP. This study confirms the close structural relationship between the two lectins showing immunological cross-reactivity of monoclonal and polyclonal antibodies recognizing distinct epitopes on rat or human HBP. In support of the suggested dual nature of p55 as lectin and ectosialyltransferase, enzyme activity is inhibited by the monoclonal anti-HBP antibody, anti-HA 116. Cultured Hodgkin's cells, as purified HBP, agglutinate T-lymphocytes expressing hyposialylated membrane glycosyl determinants. This cell-cell interaction mediated by p55 results in the incorporation of sialic acid into lymphocyte surface asialo-glycans. The function of the Hodgkin's lectin as lymphocyte agglutinant in vitro suggests its role as an immunomodulator contributing to the immunodeficiencies associated with Hodgkin's disease.
 ...
PMID:Hodgkin's cell lectin: an ectosialyltransferase and lymphocyte agglutinant related to the hepatic asialoglycoprotein receptor. 356 32


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>