Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

After two weeks' treatment of indapamide (2.5 mg/d) in 30 cases of mild to moderate hypertensive patients, there was a significant decline of systolic and diastolic blood pressure. And 8 weeks after indapamide administration, 2/3 of the total treated patients achieved complete control of hypertension. During the treatment period, there were no changes of serum cholesterol, triglyceride and renal function, except a slight, but still in the normal range, decrease of serum potassium and sodium. Concurrently, plasma vasoconstrictive prostaglandins TXB2 (metabolite of TXA2) and PGF2 alpha reduced significantly (P < 0.01 and P < 0.001 respectively), whereas plasma vasodilative prostaglandins 6-keto-PGF1 alpha (metabolite of PGI2) and PGE2 increased significantly (P < 0.02 and P < 0.05 respectively). The results support the theory that prostaglandins system may play an important role in the hypotensive process of indapamide. The influence of indapamide on prostaglandin system may favour the improvement of platelet function and the maintenance of the homeostasis.
Zhonghua Xin Xue Guan Bing Za Zhi 1992 Dec
PMID:[The effect of indapamide on plasma prostaglandins in hypertensive patients]. 130 70

The effects of svate on platelet morphology and aggregation were studied and compare with Radix Salviae Miltiorrhizae. The results showed that svate remarkably inhibited platelet aggregation in patients with coronary heart disease and hypertension. Svate could increase plasma 6-keto-PGF1 alpha and decrease plasma TXB2. After treatment with svate, levels of platelet cAMP was increased. Svate enhanced platelet 5-HT and reduced plasma 5-HT. Electron microscopic study showed that the percentage of discoid and dendritic platelets were increased, while those of spread and aggregate platelets were decreased following svate therapy. It was found that svate is superior to Radix Salviae Miltiorrhizae in inhibition of platelet function. The results indicate that svate inhibits platelet aggregation and release through increasing prostacyclin generation in the vascular wall, raising platelet cAMP and inhibition of TXA2 production.
Zhonghua Xin Xue Guan Bing Za Zhi 1991 Jun
PMID:[Effects of svate on platelet morphology and function in patients with coronary heart disease and hypertension]. 165 75

3347 males and 3927 females aged 35-54 with normal blood pressure (not on antihypertensive medication) at entry were followed up for 4 years. The incidence of hypertension and associated factors were analyzed. There was a significant difference in incidence of hypertension between southern and northern population of China (2-5 times). The age-adjusted 4 year incidence of definite hypertension in Beijing male and female workers were 6.8% and 4.1% respectively, but only 0.7% and 2.1% respectively in Guangzhou, while in Beijing farmers were 10.1%, 5.0%, and in Guangzhou farmers were 2.3%, 0.5% respectively. The results also showed incidence of hypertension were significantly correlated with body mass index (BMI). BMI greater than or equal to 24 group had higher hypertension incidence than BMI less than 24 (2.1-3.2 times). Alcohol intake was correlated to hypertension incidence rather than nonalcoholics. But no significant relations were found with smoking, educational level and the intensity of physical labour.
Zhonghua Xin Xue Guan Bing Za Zhi 1991 Aug
PMID:[The incidence of hypertension and associated factors among middle aged workers and farmers in Beijing and Guangzhou]. 181 82

A case-control study of 72 pairs indicated that stress events in daily life stimulative factor might induce the development of hypertension in susceptible persons. The sustained stress of tension and anxiety and passive mood of psychodefence could be the psychological factors inducing hypertension. Personality, as a mediated variable, has an important influence on the initiation and progress of hypertension.
Zhonghua Xin Xue Guan Bing Za Zhi 1991 Aug
PMID:[Psychosocial stress and essential hypertension]. 181 83

To evaluate the influence of isometric exercise on left ventricular (LV) diastolic function, transmittal flow velocity was measured by pulsed Doppler echocardiography before and after handgrip in 15 normal subjects and the patients with hypertension as well as 18 patients with coronary heart disease (CHD). Statistically significant differences in peak velocity of early rapid filling (Ev), the ratios of peak early to late diastolic velocity (Ev/Av) and early to late velocity-time integral (Ei/Ai) between normal subjects and both the patients with hypertension and CHD were noted at rest. After isometric exercise, significant increase in Av (0.70 +/- 0.13 vs 0.76 +/- 0.14, P less than 0.01) and Ai/total VTi (0.35 +/- 0.07 vs 0.42 +/- 0.08, P less than 0.05) were showed in the hypertension group. In CHD, multiple Doppler parameters changed after isometric exercise with increase in Av (0.70 +/- 0.16 vs 0.85 +/- 0.18, P less than 0.01) and Ai/total VTi (0.36 +/- 0.08 vs 0.42 +/- 0.08, P less than 0.01) as well as decrease in Ev/Av (0.95 +/- 0.22 vs 0.82 +/- 0.15, P less than 0.05) and Ei/Ai (1.64 +/- 0.51 vs 1.35 +/- 0.34, P less than 0.05). However, there was no significant difference in any Doppler indices of LV diastolic function in the present normal subjects after isometric exercise. Thus, isometric exercise further enhanced late LV diastolic filling in the patients with impaired LV diastolic function in resting states greater than normal subjects, and myocardial ischemia induced by handgrip may play partial role in more changes in Doppler indices of LV diastolic function in CHD than the patients with hypertension.
Zhonghua Xin Xue Guan Bing Za Zhi 1991 Oct
PMID:[Influence of isometric exercise on left ventricular diastolic function in the normal subjects and in patients with hypertension and coronary heart disease]. 181 17

Thirty hypertensive patients with increased left ventricular (LV) mass and impaired diastolic function received routinely 2 or 3 kinds of captopril, nifedipine and atenolol for a mean period of 98 days. The LV mass index (LVMI) decreased by an average of 21 g/M2, but no significant correlation between blood pressure reduction and decrease in LVMI was found. So there may be some direct effect of these antihypertensive agents on the myocardium in addition to the benefit from blood pressure reduction. Marked reduction in PVA, Ai, A/E and Ai/T-VTi (P less than 0.01) along with elevation in ratio of E/A, Ei/Ai and Ei/T-VTi (P less than 0.01) were also observed by Doppler transmitral filling studies. These results indicated that the impaired LV diastolic function in patients with hypertension can be much improved following reduction of blood pressure and LV mass.
Zhonghua Xin Xue Guan Bing Za Zhi 1991 Dec
PMID:[The effect of lowered pressure on the diastolic ventricular function after antihypertensive treatment]. 184 Mar 64

A computer-assisted method for quantitating coronary arteriograms was applied to measure the diameter of major epicardial coronary arteries in 58 normal subjects and 25 hypertensive patients, and to determine the percentage of relative stenosis of coronary lesions in 109 patients with coronary artery disease. Average coronary size was larger than normal in patients with hypertension. The left coronary artery was larger than the right coronary artery in the majority of patients. The degree of coronary stenosis can be measured accurately with good reproducibility. Thus this inexpensive microprocessor system provides rapid quantitation of coronary artery diameter and lesions.
Zhonghua Xin Xue Guan Bing Za Zhi 1991 Apr
PMID:[Quantitative analysis of coronary arteriogram by a computer-assisted method]. 187 19

Several abnormalities of calcium transport have been reported in human essential hypertension (EHT) and spontaneous hypertensive rat (SHR). 45Ca binding capacity to erythrocyte membrane was measured in this study by filtration technique in the presence of 80 nmol/L Ca concentration. Results showed: (1) It was much lower in EHT (33 cases) than normal control (19 men) group, being 0.22 +/- 0.13 versus 0.35 +/- 0.18 nmol Ca2+/mg membrane protein (P less than 0.01), and correlated positively with blood pressure levels. (2) The average Ca binding capacity in young offsprings (15 adolescents) with both parents hypertensive was lower, but statistically not significant. (3) The average Ca binding capacity was also lower in SHR (9 rats) than control WKY (10 rats) group, being 0.83 +/- 0.27 versus 0.98 +/- 0.24 nmol Ca2+/mg membrane protein, yet statistically not significant. Therefore a decrement of membrane binding capacity might be related to the occurrence and maintenance of hypertension.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Oct
PMID:[Calcium binding capacity of erythrocyte membrane in human hypertension and spontaneous hypertensive rats]. 196 95

To study whether left ventricular mass and function are related to the activity of the sympathetic nerves in progeny of hypertensive parents, LV parameters by echocardiography and plasma catecholamines by HPLC were used in 33 normotensive sons with two hypertensive parents (SHT) and 33 normotensive sons without family history of hypertension (SNT). The results showed that interventricular septum and left ventricular posterior wall thickness, left ventricular mass were significantly greater in SHT group than in the SNT group. No significant difference was found in plasma catecholamines between SNT group and SHT group. But, positive correlation between left ventricular mass and plasma norepinephrine was observed both in SHT group and SNT group. The regression coefficient in SNT was greater than that in SHT. The left ventricular mass and plasma epinephrine were positively correlated in SHT group. These results suggest that cardiac involvement may precede blood pressure elevation in SHT group and the changes of cardiac morphology might show that myocardium is more sensitive to the activity of sympathetic nerves system in SHT than in SNT.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Oct
PMID:[Relation between left ventricular mass and function with plasma catecholamines in progeny of hypertensive parents]. 208 89

The levels of total cholesterol, triglyceride, LDL-C, HDL-C, apolipoprotein A1 and apolipoprotein B in the serum were measured in a selected series of 100 CAD patients (77 men and 23 women) who underwent coronary angiography and 141 non-CAD controls. Mean values of those variables differed significantly between the CAD and non-CAD groups matched in age, body weight, hypertension and smoking. There are significant difference in apolipoproteins A1, B and the ratio of apolipoprotein B to A1 between angina and myocardial infarction groups. Using stratified and multivariate stepwise regression analysis, it was shown that the apo A1, apoB/apoA1 are more sensitive and specific than the ordinary indices (e.g. total cholesterol, triglycerides, LDL-C and HDL-C) in estimating the degree of coronary artery stenosis and the differentiation of CAD from other diseases.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Aug
PMID:[Serum apolipoprotein AI, B levels in patients with coronary diseases]. 212 69


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