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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The studies concerned fifteen men with a stable angina pectoris--confirmed by an exercise test and coronarography--but with no heart failure or hypertension. They were randomly tested in a double blind method in which cardiovascular system was checked by means of rheographic-cardiography each fortnight after alternate administration of the placebo and verapamil [3 x 120 mg/24 hr]. After verapamil significant lowering of blood pressure and significant decrease of heart rate were found. Rheographic-cardiographic indices of cardias performance: RE time, REc time relation to heart rate, E dz/dt, E dz/dt relation to changes in arterial blood pressure, Heather index, modified Heather index, RE/EX and LVET did not show changes statistically significant. Neither was the change of the index of left ventricle heart failure observed. The only real change was the lengthening of the EX period--depending on the afterload. We can conclude that in patients with a stable angina pectoris the administration of 3 x 120 mg of verapamil does not diminish cardiac performance.
Pol Arch Med Wewn 1991 Apr
PMID:[Evaluation of verapamil's effect on the circulation in angina pectoris]. 188 31

Osler's maneuver which makes it possible to detect phenomenon of pseudo-hypertension was performed in 64 patients with elevated blood pressure when measured by Korotkoff's method. In 14 patients with essential hypertension and 14 patients with pseudo-hypertension the effect of 9 days hypotensive treatment with furosemide on renal function was compared. 22% of studied patients revealed pseudo-hypertension. The drop in arterial pressure caused a significant increase in the plasma urea, as well as a significant decrease in creatinine clearance and uric acid clearance in patients with pseudo-hypertension. These changes were not observed in patients with essential hypertension. Antihypertensive treatment of patients with pseudo-hypertension is hazardous due to the possibility of adverse effects caused by diminished tissue flow. Before starting the hypotensive therapy in elderly patients it is advisable to exclude pseudo-hypertension by means of Osler's maneuver.
Pol Arch Med Wewn 1991 Apr
PMID:[Effect of hypotensive treatment on renal function in patients with pseudo-hypertension]. 188 32

In 35 patients with ischemic heart disease we evaluated the incidence of ventricular late potentials and left ventricular function. The patients were divided into two groups: group A consisting of 15 patients (14 men, 1 woman) aged from 40 to 71 years (mean age 56) with previously documented ventricular tachycardia or fibrillation, and into group B comprising 20 subject (16 men, 4 women) aged from 35 to 62 years (mean age 50) with ischemic heart disease without the above-mentioned arrhythmias. Time from the development of ventricular tachycardia or fibrillation was 3 weeks to 4 years. The incidence of arterial hypertension and previous myocardial infarction was similar in both groups. Body surface late potentials were recorded by signal averaging technique according to Simson using Frank's orthogonal XYZ lead system. In addition, in all the patients 24-hour ECG monitoring was performed to reveal any ventricular rhythm disturbances and echocardiography was used to evaluate left ventricular function. The presence of the ventricular late potentials meeting at least two of the Simson's--Dene's criteria was found in 13 (87%) patients in group A and in 2 (10%) patients from group B. In the patients after ventricular tachycardia or fibrillation the mean values of th total QRS duration (QRS-D) and the low amplitude signal duration (LAS40) were higher whereas the root mean square voltage of the last 40 ms of th vector magnitude QRS (RMS) was lower (154 ms, 56 ms, 15 muV, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
Kardiol Pol 1991
PMID:[Signal-averaged ECG and left-ventricular function in patients with severe ventricular arrhythmia in ischemic heart disease]. 192 Nov 5

In 40 patients (pts) with essential hypertension (EH) the plasma levels of insulin, glucagon, gastrin and prolactin during 2 week therapy with nifedipine were evaluated. In pts with EH there were higher levels of hormones than in control subjects. During nifedipine therapy there was no elevation of the plasma hormone levels although the blood pressure was lowered. This study shows that there are other than hypertension factors in the pathogenesis of elevated hormone levels in EH.
Kardiol Pol 1991
PMID:[Essential hypertension. Treatment with nifedipine and levels of insulin, glucagon, gastrin and prolactin]. 194 46

In 78 patients with mild or moderate hypertension, effect of acebutolol and hydrochlorothiazide on plasma lipids, lipoproteins, fibrinogen and plasma fibrinolysis time were investigated. 42 patients were treated with acebutolol for 18 months and 36 with hydrochlorothiazide for 24 months. It was shown that neither acebutolol nor hydrochlorothiazide induced significant alterations in investigated biochemical risk factors. The possible causes of controversy encountered in literature and analysis of factors which may influence the character and severity of metabolic disorders resulting from antihypertensive therapy were discussed.
Kardiol Pol 1991
PMID:[Does chronic therapy of hypertension with acebutolol or hydrochlorothiazide effect coronary risk factors?]. 204 25

Basic haemodynamic parameters - blood volume (BV), cardiac output (CO), stroke volume (SV), and total peripheral resistance (TPR) were studied in two groups of overweight patients with mild and moderate hypertension. Each group consisted of 15 subjects. The patients of the first group were kept on low caloric diet (1000-1100 cal per day). Patients of the second-control-group were treated with propranolol (120 mg per day). The duration of each study was 24 weeks. Blood pressure fell due to body weight reduction. BV, CO and SV decreased without changes in TPR. In the control group treated with propranolol in which the body weight did not change a fall in blood pressure, cardiac output, and stroke volume was seen without changes in blood volume and total peripheral resistance values.
Pol Arch Med Wewn 1991 Mar
PMID:[Selected hemodynamic parameters in overweight patients with mild and moderate hypertension treated with low caloric diet]. 205 19

The aim of the study was to assess the usefulness of 24-hour blood pressure (BP) and heart rate (HR) monitoring in patients with "resistant" hypertension. 30 patients (44.1 +/- 9.9 years) with diastolic BP 100 mm Hg or more in spite of treatment with three or more antihypertensive drugs were studied. Ambulatory recording of BP and HR was performed by means of Del Mar Avionics monitoring system 9000. Mean recording time was 21.5 hours and mean number of measurements during one recording--56.7. Mean ambulatory systolic and diastolic BP values were significantly lower than mean value of three casual measurements (146.0 +/- 24.6 vs 171.5 +/- 21.2 mm Hg for systolic and 97.2 +/- 11.3 vs 110.4 +/- 7.5 mm Hg for diastolic BP p less than 0.01) In 14 (46.6%) systolic BP and in 10 patients (33.3%) diastolic BP were normal. The patients with normal and abnormal ambulatory BP recordings did not differ in regard to age and mean clinic BP levels. However, patients with abnormal ambulatory BP recordings were more often overweight and showed a greater frequency of left ventricular hypertrophy and family history of hypertension and its complications. The results of the study show that ambulatory BP monitoring may be of value in assessing the response to antihypertensive treatment in patients with so called resistant hypertension as judged on the basis of clinic pressure.
Kardiol Pol 1990
PMID:[Ambulatory 24-hour blood pressure monitoring in patients with resistant hypertension]. 207 34

The paper presents an adverse effect of Lorcainide on the electrocardiographic pattern and left ventricular function in a patient with recurrent ventricular tachycardia in the course of arterial hypertension and ischemic heart disease. Based upon this case report a relatively new and not well known phenomenon of drug arrhythmogenesis is presented.
Kardiol Pol 1990
PMID:[The effects of lorcainide on the ECG pattern and left ventricular function in a patient with recurrent ventricular tachycardia]. 207 42

Out of 1800 men and 1800 women being the random sample of population of two Warsaw districts aged 35-64 years, 1309 men and 1337 women (response rate 72.7% and 74.3% were screened in 1984 within the framework of the Pol-MONICA Warsaw Project. Standardized mean values of systolic blood pressure did not differ between men and women but the mean values of diastolic blood pressure were higher in men. Mean values of systolic and diastolic blood pressure increased in both sexes with age, however diastolic blood pressure increased only up to age 45-54 years. Prevalence of hypertension according to WHO criteria was higher in men than in women and in both sexes increased with age. Among subjects with hypertension the mild diastolic hypertension was most frequent. The high percentage of subjects with hypertension at screening was not previously detected (47.4% men and 27.6% women). The fact of hypertension detection was not equal with undertaking therapy because 58.9% men and 46.6% women with detected hypertension were never treated. The effectiveness of therapy (achieving goal) was 24% in men and 27.4% in women. The performed multiple regression analysis indicated that Quetelet index and pulse rate were independently related with systolic blood pressure in both sexes and additionally education level, alcohol consumption and HDL-cholesterol concentration in men and age and family history of hypertension in women. As far as the diastolic blood pressure is concerned the Quetelet index, pulse rate and family history were significantly related in both sexes and additionally in men ethanol consumption and HDL-cholesterol concentration.
Pol Arch Med Wewn 1990 Oct
PMID:[Long-term Pol-MONICA-Warsaw project: pattern of blood pressure among the population and the effects of selected factors on the blood pressure level]. 208 Jan 15

The purpose of the study was to describe the clinical picture in patients with ischemic heart disease (IHD) and verifying severity of ventricular arrhythmias. The study included 856 patients with IHD aged 23-88 years (mean = 55.3), including 659 men and 197 women. Holter monitoring was performed in all patients. Ventricular arrhythmias were graded according to Lown. The patients were divided into five groups: group 1-349 patients with Lown's grade 1 and 2; group 2-95 patients with grade 3; group 3-152 patients with grade 4a and 4b; group 4-11 patients with grade 5; group 5-507 patients (selected from groups 2, 3 and 4) with Lown's grade 3 and 4 or 5. Arterial hypertension was found in 17.1%, myocardial infraction in 66%, and syncope in 12.3% of the patients. The patients with complex ventricular arrhythmias versus Lown's grade 1 and 2 show significant differences especially in respect to: the frequency of previous anterior myocardial infraction, the incidence of pain at rest, loss consciousness, the frequency of ventricular tachycardia and fibrillation, anginal pain and exercise-related arrhythmias. The patients with Lown's ventricular arrhythmia grade 3-5 do not differ significantly in their clinical manifestations of IHD from the patients with ventricular arrhythmias grade from 3 to 5. The development of silent myocardial ischemia during exercise stress testing is typical also for the patients with complex ventricular arrhythmias. A decreased contractility index, ejection fraction and dyskinesis are significantly more frequent in the patients with complex ventricular arrhythmias.
Kardiol Pol 1990 Mar
PMID:[Complex ventricular arrhythmias in ischemic heart disease]. 208 68


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