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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One of the major problems being researched and studied by the World Health Organization is the incidence of harmful side effects in users of steroid contraceptives. A literature search indicates that Anglo-Saxon countries report alarming hyperplastic changes, particularly in the liver, blood clots, hyperlipidemia leading to high blood pressure, porphyria, atypical leiomyomas and cervical hyperplasia. Currently attention is being focused on the relationship between steroid contraceptives and breast cancer. Fazala and Paffenbarger in their study of 1770 women found such benign changes as fibroadenoma, mastopathia fibrosa cystica and papilloma intraductale. In women who had used oral contraceptives for 2-4 yrs, malignancies were 1.9% to 2.5% more frequent than in non-users; in 6 yrs of use, 11 times greater than in non-users. Estrogens, particularly mestranol has been recognized as being harmful to the liver. Length of usage is a definite factor. Beginning with 1960, relatively frequent occurrences of hepotoma in young women on the pill were noted. Caught at an early stage, peliosis hepatis can be reversed if the patient discontinues the use of contraceptives. In some cases, even after a long interval of 6 months to 10 yrs, the disease continued to develop. Liver cell adenoma in the U. S. occurs 1/500,00 to 1/1,000,000. After 5 to 7 yrs of using oral contraceptives, the chance of developing liver cell adenoma is 5 times greater; after 10 yrs of use, 35 times greater. Hepatomas rupture in 43.4% of cases when the patient had been on a contraceptive, while in only 22.2% in cases of non-users. The literature which the author investigated did not establish a clear proof that the hyperplastic changes discussed were due exclusively to usage of oral contraceptives.
Pol Tyg Lek 1978 Sep 18
PMID:[Hyperplastic changes and oral contraceptives in Anglo-Saxon countries]. 69 6

Risk factors were compared in 300 patients with brain stroke and 120 patients with neurosis or sciatic pains. It was found that arterial hypertension (p = 0.001) and diabetes (p = 0.01) were significantly more frequent in cases of brain stroke. Disturbances of lipid metabolism, tobacco smoking and obesity showed no significant difference. Extracerebral atherosclerosis (p = 0.001) increased the risk of stroke. Coronary arterial disease was most frequent (48.8%), myocardial infarction (8.3%) and calcifications in the aorta (32%) were second and third in frequency. Presence of at least two risk factors may be an indication to prophylactic treatment.
Neurol Neurochir Pol 1978
PMID:[Risk factors in stroke]. 72 25

A case of epiphyseal tumour diagnosed by means of positive-contrast ventriculography in a male patient is reported. Treatment included ventriculoatriostomy and radiotherapy. In the clinical picture of the disease signs of intracranial hypertension prevailed together with hypothalamic endocrine disturbances, and in view of absent pathognomonic signs of lamina quadrigemina lesion considerable difficulties were encountered and craniopharyngioma was suspected. In the light of the pertinent literature and the present observations the possibility of early diagnosis of epiphyseal tumours based on disturbances of vertical optokinetic nystagmus and changes in auditory tests deserves attention.
Neurol Neurochir Pol
PMID:[Case of pineal body tumor]. 72 52

An unusually severe and uncommon clinical syndrome of migraine with complications in a boy treated during 9 years is described. Severe attacks of migraine were associated with changing cerebral function defects, prolonged disturbances of consciousness, and significant symptoms of intracranial hypertension. Vertebral angiography demonstrated disturbances in cerebral circulation.
Neurol Neurochir Pol
PMID:[Case of a particularly severe migraine in a boy]. 72 54

The activity of acetylcholinesterase was assessed in the rat brain in nephrogenic hypertension and after angiotensin administration. No significant differences were found in relation to corresponding control groups.
Acta Physiol Pol
PMID:Acetylcholinesterase activity in the rat brain during nephrogenic arterial hypertension and after angiotensin administration. 74 71

5-hydroxydopamine, unspecific centrally acting false neurotransmitter. Acta Physiol. Pol., 1977, 28 (1): 13-22. 3,4,5-trihydroxyphenetylamine-5-hydroxydopamine (5-OHDA) injected intracerebro-ventricularly decreases the level of noradrenaline, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in different parts of the rat brain. It does not affect acetylcholine level. 5-OHDA causes dose-dependent hypothermia, transient hypertension and depression of locomotor and exploratory activity in rats. This behavioral phenomena are reversed by central chemical sympathectomy elicited by 6-hydroxydopamine. It is concluded that 5-OHDA is an unspecific centrally acting false transmitter.
Acta Physiol Pol
PMID:5-hydroxydopamine, unspecific centrally acting false neurotransmitter. 86 21

The authors analysed clinically 108 patients (61 males and 47 females), aged below 50 years treated at the department of neurology, because of acute cerebral ischaemia. Attention is called to risk factors such as arterial hypertension, heart disease, atherosclerosis, obesity and diabetes which may be the cause of earlier development of ischaemic changes in the central nervous system. In the analysed group in 18 cases cerebral thrombosis, in 23 cases embolism, in 31 cerebral circulatory failure were diagnosed. In 36 cases the cause could not have been established.
Neurol Neurochir Pol 1977
PMID:[Acute cerebral ischemic disease in patients under the age of 50]. 88 1

Extracranial hypertension was produced in cats by means of epidural compression with a baloon. After 2 hours of compression sudden decompression was performed and tissue pressure was compared at symmetrical sites of cerebral hemispheres with cerebrospinal fluid pressure measured in the cisterna magna. It was found that symmetrical tissue pystem, which was due probably to early oedema developing in the compressed area.
Neurol Neurochir Pol 1977
PMID:[Effect of sudden decompression on tissue pressure in the brain and the cerebrospinal fluid pressure]. 88 9

Experimental hypertension was induced in rats by two methods. In the course of hypertension development the rats of experimental groups were treated with following tricyclic antidepressive agents: Imipramine, Opipramol, Amitriptylline and Nortriptylline injected in doses of 5.0 or 0.5 mg per 1 kg of body weight. Higher doses of the above drugs inhibited the development of hypertension, whereas the lower doses had no effect on arterial blood pressure.
Acta Physiol Pol
PMID:Effect of thymoanaleptic agents on the course of experimental arterial hypertension and catecholamine content in tissues and urine. 89 10

The case of a 35-year-old woman who demonstrated androgenic obesity, absence of ovulation, and amenorrhea is examined. This patient showed arterial hypertension, diabetes mellitus, hirsutism, and anovulatory cycles. A very high concentration of estrone was noted in the urine, originating in the adrenal glands. These indications are generally considered during evaluation of breast or uterine cancer threat. Administration of dexamethasone led to a decrease in urinary estrone to insignificant levels. Stimulation with human chorionic gonadotropin caused an increase in ovarian activity. The disruptions this patient suffered were attributed to hormonal imbalances attributed to her obesity, primarily in regard to estrogen metabolism.
Ginekol Pol 1977 Aug
PMID:[Uncommonly high concentration of estrone of adrenal origin in a case of androgenic obesity, anovulation and amenorrhea]. 90 13


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