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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this third report on the management of hypertension by general practitioners and hospital physicians we review hospital outpatient practice in a representative sample of 90 new patients and 436 returning patients attending the clinics of three Edinburgh hospitals. Seventyeight per cent of the new patients were seen by a consultant or senior registrar. An unacceptable number of deficiencies was found in clinical assessment and these are discussed. Consultants are shown to be more conservative than junior hospital doctors in their treatment of hypertension.
J R Coll Gen Pract 1983 Apr
PMID:Management of hypertension--a study of hospital outpatient practice. 688 90

In 1974 eight general practitioners decided to co-operate in a hypertension screening exercise in their practices. The reasons for the survey and the methodology are described and the results of screening over 28,000 patients are given. The cut-off point for normal diastolic blood pressure was 89 mmHg and 23,979 (85 per cent) patients were considered to be normosensitive on this criterion, 694 (2.5 per cent) patients were already known by their doctors to have hypertension; 991 (3.5 per cent) had an initial abnormal reading but subsequent readings were normal. The survey identified 2,018 patients (7.12 per cent) as being hypertensive and 575 (2 per cent) failed to complete the survey. Because of the ever-changing population in the practices, 100 per cent surveillance was not achieved. It is considered necessary to carry out continuous case finding for the presence of hypertensive patients in general practice.
J R Coll Gen Pract 1983 Jul
PMID:Hypertension screening in general practice. Report on behalf of the General Practitioner Hypertension Study Group. 688 13

1. The effects of 10-min perfusions of diltiazem (o.1-2.5 mg/kg, i.v.) on arterial blood pressure were studied in anesthetized renovascular-hypertensive and in normotensive rats. 2. Diltiazem produced a dose-dependent decrease in blood pressure in hypertensive rats (ED50 congruent to 1 mg/kg). 3. Diltiazem also decreased blood pressure in normotensive rats, but this action was less sustained than in hypertensive rats. 4. These results support the contention that diltiazem might be useful for treating arterial hypertension.
Gen Pharmacol 1982
PMID:Effects of diltiazem on renovascular-hypertensive and on normotensive rats. 709 96

Quality of life after antihypertensive therapy was assessed in 75 patients with controlled hypertension using questionnaires given to patients, close companions and doctors. The overall assessments of the three groups differed significantly.The questionnaire completed by relatives rated 19 patients (25 per cent) to have suffered mild adverse changes, 33 patients (45 per cent) to have had moderate adverse changes and 22 patients (30 per cent) severe adverse changes. The deteriorations were attributed to undue pre-occupation with sickness, decline in energy, general activity and sexual activity, and irritability. The implications of the therapeutic regimes are discussed. The value of such an assessment in social readjustment and occupational rehabilitation is suggested.
J R Coll Gen Pract 1982 Feb
PMID:The effect of hypotensive drugs on the quality of life. 709 28

We have examined the use of tranquillizers by 7,735 middle-aged men currently enrolled in the British Regional Heart Study, a prospective study of cardiovascular disease in 24 towns throughout Great Britain. Tranquillizer use was reported by 620 men (8 per cent). There was a slightly greater prevalence of tranquillizer use in the older men and the non-manual workers. Men with physical disease diagnosed by their doctor or by objective measurements during the study were more likely to be using tranquillizers than men with no physical disease. This was most evident for ischaemic heart disease, however diagnosed, and for hypertension diagnosed by their doctors. There was an inverse relationship between drinking and tranquillizer usage: heavy drinkers had lower rates of usage. There was no association between tranquillizer use and smoking habits.This study indicates that tranquillizer use in these middle-aged men is little influenced by age, social class or smoking, but that there is a strong, positive association between tranquillizer use and the presence of doctor-diagnosed physical disease. While our data provide support for the suggestion that alcohol and tranquillizers may be used interchangeably by some individuals, this finding could also be an outcome of doctors' and patients' awareness of the undesirable effects of combining alcohol and tranquillizers.
J R Coll Gen Pract 1982 Dec
PMID:Tranquillizer use in middle-aged British men. 715 75

The Finnish sickness insurance scheme provides for free medicines for patients suffering from certain chronic diseases, such as hypertension. The level of control of hypertension among a group of 169 patients receiving free medicine was found to be inadequate. There are implications both for the prognosis of the patients and the cost-effectiveness of the free medicine programme.
J R Coll Gen Pract 1981 Apr
PMID:Assessing the adequacy of antihypertensive treatment in a health centre in finland. 727 3

The feasibility of blood pressure measurement by general practice pharmacists was examined in nine pharmacies. Two hundred and fifteen subjects were screened and 13 were referred to their general practitioners. Ten subjects (five per cent of the initial sample) were confirmed to be hypertensive by their doctors. The upper limits of normotension were 160/100 mmHg aged up to 50 years, 160/105 mmHg aged 51-60 years and a diastolic pressure of 110 mmHg over 60 years. Ninety-eight per cent of a sample of the lay public who completed a written questionnaire were in favour of blood pressure measurement by pharmacists. The study showed that general practice pharmacists were able to measure blood pressure within acceptable limits of accuracy and that, with the collaboration of general practitioners, the pharmacies were suitable agencies for screening for hypertension.
J R Coll Gen Pract 1981 Nov
PMID:Blood pressure measurement by pharmacists. 732 53

Wheat basic/leucine zipper protein HBP-1a(17) binds in vitro specifically to ACGT motif-containing cis-acting elements, such as the type I element of plant histone promoters and the G-box of hormone- and light-inducible promoters. To address the in vivo function of HBP-1a(17), we isolated and structurally analyzed the HBP-1a(17) gene and examined its expression in transgenic Arabidopsis plants. The HBP-1a(17) gene is composed of 14 exons; the basic region and leucine zipper are encoded by separate small exons, as is the case for other bZIP protein genes. The G-box of the HBP-1a(17) promoter bound specifically to HBP-1a(17) and its related HBP-1a isoforms, suggesting that the HBP-1a(17) gene may be autoregulated, although the binding affinity of these proteins in vitro is very low. In Arabidopsis plants, activation of the HBP-1a(17) promoter was highly restricted to photosynthetically active mesophyll, and guard cells and vascular bundles of vegetative leaves. Etiolation of transgenic plants resulted in inhibition of expression of the HBP-1a(17) promoter. Indeed, the HBP-1a(17) promoter contains several sequence elements homologous to cis-acting elements conserved in light-inducible promoters. It is, therefore, assumed that the HBP-1a(17) gene is light regulated and that HBP-1a(17) is involved in light-responsive gene transcription via the G-box.
Mol Gen Genet 1995 Sep 20
PMID:Developmental and tissue-specific regulation of the gene for the wheat basic/leucine zipper protein HBP-1a(17) in transgenic Arabidopsis plants. 747 57

The utility of renal revascularization to control hypertension secondary to renal artery occlusive disease is widely recognized. However, revascularization for purposes of renal salvage, although performed successfully in many instances, is a more difficult issue, owing to the higher morbidity and mortality rates associated with operative intervention in an older patient population with significant comorbid conditions. It is therefore imperative to appropriately select patients who may benefit from revascularization, and the aim of our discussion is to aid in this selection process.
Curr Opin Gen Surg 1994
PMID:Ischemic nephropathy as an indication for renal artery reconstruction in renovascular hypertension. 758 90

1. Prolonged existence of hypertension is known to induce a compensatory increase in cardiac weight, later followed by a loss of functional responsiveness to biological stimuli. 2. It was the aim of the present study to investigate the functional responses of hypertrophied hearts to rising levels of intracellular calcium. The experiments were performed using two different degrees of cardiac hypertrophy, the first as obtained in spontaneously hypertensive rats (SHR) of 18-20 weeks old, the second by using rats, 32-34 weeks old, with a surgically induced stenosis of the thoracic aorta (ASR). The ASR, which showed signs of overt heart failure, may be presented as a model for hypertension-induced end-stage cardiac hypertrophy. Age-matched normotensive Wistar-Kyoto rats (WKY) and sham-operated Wistar rats served as respective controls. 3. Different methods were employed such as increasing the extracellular Ca2+ concentration, stimulation of calcium influx by means of the calcium entry promoter Bay K 8644, or altering the sodium-calcium exchange by means of the sodium ionophore monensin. 4. The inotropic responses induced by increasing the extracellular Ca2+ concentration or provoked by the calcium entry promoter Bay K 8644 proved more pronounced in hearts taken from SHR of 18 weeks old than in those from normotensive control rats, whereas the response to monensin was found to be the same in both types of hearts. In the hearts of ASR, however, the inotropic responses to Ca2+, Bay K 8644 and monensin were strongly impaired. 5. These data demonstrate that in functional experiments the sensitivity to Ca2+, which represents the main pathway in establishing a contraction, is strongly reduced in advanced cardiac hypertrophy.
Gen Pharmacol 1995 Mar
PMID:Sensitivity of cardiac tissues with moderate and advanced hypertrophy to calcium ions. 759 94


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