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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a retrospective survey of renal amyloidosis in a large general hospital, only 7 cases were found. Patients generally presented with nephrotic syndrome and symptoms of fluid overload; hypertension on presentation was unusual. Renal failure was present in 5 out of 7 patients, and uraemia in 3. The disease was secondary in 5 patients and primary in 2, and the prognosis was uniformly bad.
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PMID:Renal amyloidosis in blacks. 50 98

Over a 16-year period, 205 patients with hypertension were shown to have a renovascular aetiology. Of these, 125 (61 per cent) had Takayasu's arteritis, 58 (28.3 per cent) had fibromuscular dysplasia, 16 (7.8 per cent) had atherosclerosis, five (2.4 per cent) had polyarteritis nodosa and one (0.5 per cent) had renal artery aneurysm. Among patients with Takayasu's arteritis, males were affected as commonly as females. The mean age of these patients at the time of detection was 26.8 +/- 8.6 years (range 5-52 years). Type I arteritis was seen in nine (7.2 per cent), Type II in 40 (32 per cent) and Type III in 76 (60.8 per cent) patients. The abdominal aorta was involved in 117 (93.3 per cent) patients. Takayasu's arteritis was associated with ulcerative colitis in two patients and with renal amyloidosis and focal segmental glomerulosclerosis with a nephrotic syndrome in one patient each. Surgical intervention consisting of bypass procedures, autotransplantation or nephrectomy was performed in 17 (13.6 per cent) and angioplasty in nine (7.2 per cent) patients. Cure and improvement in blood pressure was observed in 82.4 per cent and 77.8 per cent respectively. Adequate control of blood pressure was achieved with drugs only in 22 (22.2 per cent) patients. A definite cause and effect relationship could not be established between any infective or immunological disorder and Takayasu's arteritis. Takayasu's arteritis is a far more common cause of renovascular hypertension in Indian population than fibromuscular dysplasia or atherosclerosis, which are more common in the western population.
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PMID:Renovascular hypertension due to Takayasu's arteritis among Indian patients. 136 62

Spontaneous (not experimentally induced) systemic hypertension was detected in 5 male dogs that were examined because of apparent blindness caused by intraocular hemorrhage and/or retinal detachment. Secondary causes of hypertension, including renal, adrenal, and thyroid disease, were investigated. Four of the dogs had glomerulonephropathy, renal insufficiency, and proteinuria. Four dogs had compensatory cardiac hypertrophy. Hypertension in 4 of 5 dogs was associated with glomerulosclerosis with chronic renal insufficiency, bilateral adrenocortical hyperplasia, adrenocortical adenoma with renal amyloidosis, and immune-mediated glomerulonephritis with chronic renal insufficiency, respectively. The fifth dog was determined to have essential hypertension. The dogs were treated for their primary diseases. Sodium restriction alone was inadequate to reduce blood pressure; 4 of the dogs also required antihypertensive medications.
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PMID:Spontaneous systemic hypertension in dogs: five cases (1981-1983). 317 Mar 25

Fourteen consecutive patients with chronic inflammatory rheumatic disease and reactive renal amyloidosis were treated with alkylating cytostatics in 22 separate periods varying in duration between six and 30 months. Chlorambucil alone was given in 14 treatment periods, cyclophosphamide alone in six, and both alternately in two. The dosage was adjusted to attain a major suppression of the rheumatic inflammation and a blood lymphocyte level below 1.0 X 10(9)/l. Renal function improved in 12 treatment periods, renal deterioration was arrested in three periods, and in another four periods the rate of functional decline slowed down. In the remaining three treatment periods, associated with further deterioration in renal function, treatment was inadequate owing to blood dyscrasia and failure to control hypertension. Glomerular filtration rate (GFR) was followed more closely in 10 treatment periods, in all of which the falling trend was arrested or reduced. The survival rate at five years was 93%. Three patients who dropped out of the treatment programme are so far the only ones not still alive. Nine are still being followed up after 6-17 years, and the other two remaining live patients have had renal transplants for five years.
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PMID:Alkylating cytostatic treatment in renal amyloidosis secondary to rheumatic disease. 350 Jun 78

The incidence of arterial hypertension (AH) in patients with renal amyloidosis varied with its stage. Thus, AH was encountered in 13% of cases with renal amyloidosis at the proteinuric stage, 15% of those at the nephrotic stage, and 53% of those at the azotemic stage. One determinant of AH at the first two of these stages appears to have been damage to the antihypertensive system of the renal medulla, while the increased rate of AH at the azotemic stage was found to be associated with sodium retention in the body. AH in renal amyloidosis is an unfavorable prognostic factor, for it is conducive to amyloid shrinkage of the kidneys and to chronic renal failure.
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PMID:[Arterial hypertension in renal amyloidosis (a clinico-morphological analysis)]. 366 48

The authors presented the results of a clinical study of an atypical course of secondary renal amyloidosis developing in a patient with pulmonary tuberculosis and progressing against a background of chronic post-tuberculosis bronchitis. The disease manifested itself in the acute development of the nephrotic syndrome which could be arrested as a result of tuberculostatic therapy. Clinico-laboratory signs of the disease were absent for 20 yrs., then arterial hypertension and chronic renal failure accompanied by minimum proteinuria, developed. The diagnosis of renal amyloidosis was confirmed by nephrobiopsy. Considerable difficulties arose in differential diagnosis with glomerulonephritis in such a clinical course.
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PMID:[Long-term remission of the nephrotic syndrome in renal amyloidosis]. 376 49

Authors review their own experience in PAN, Lupus ery thematosus and renal Amyloidosis. Two patients with PAN, both with arterial hypertension: one of them of macrosco pic type, presenting great aneurysms localized in brain and in renal arteries; the other patient had microscopic type, with good response to corticotherapy after three years of follow-up. Four patients with lupus erythematosus nephritis; kidney biopsy was performed in three of them: two cases with membranoproliferative glomerulonephritis, and the last one with extramembranos glomerulonephritis. All of them had nephrotic syndrome, and arterial hypertension. Seven patients with renal amyloidosis, four related to reumatoid artritis, two related to mucoviscidosis and the las case was a patient with recurrent mediterranean fever.
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PMID:[Collagenosis nephropathies]. 611 54

A mechanical device was successfully used in therapeutic renal artery occlusion in a patient with renal amyloidosis and massive proteinuria (25 g/day). The serum albumin level increased from 1.8 to 3.4 g/dL after cessation of proteinuria. There has been no evidence of peripheral embolization, hypertension, or infection of the infarcted kidney for the past 20 months following the procedure.
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PMID:Renal infarction with Gianturco wool coils. Use in the management of massive proteinuria. 689 29

Clinical renal abnormalities, including haematuria, proteinuria, abnormal urinary sediment, decreased renal functions and hypertension are relatively common in children with juvenile rheumatoid arthritis (JRA). These findings may be due to renal amyloidosis or administration of drugs that are potentially nephrotoxic. The case of an 11 years old boy diagnosed as JRA at 4.5 months of age and treated with steroids for 10 years is presented. In his history he had hypertension for 5 years and cataract for one year. Renal biopsy was done to evaluate the aetiology for proteinuria, which was overlooked before his admission to our Department. Secondary renal amyloidosis due to JRA was found at biopsy. The importance of investigation for amyloidosis during the long-term follow-up of JRA is reemphasized.
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PMID:Juvenile rheumatoid arthritis and renal amyloidosis (case report). 759 86

This paper presents the incidence of glomerulonephritis (-pathy: GN) from a large number of more than 10,000 serial renal biopsies examined in one laboratory using the same criteria over the past 25 yrs. in Japan. Each incidence is as follows: IgA nephropathy (IgAN), 33%; thin glomerular basement membrane disease (TBMD), 17.8; athletic pausal urinary abnormality (APUA), 8.2; primary membranous glomerulonephritis (memb GN), 6.5; while all others were less than 5% each. Out of 3,300 IgAN cases, 51% consisted of a minimal change IgAN (MCIgAN), while the IgAN cases with moderate to severe glomerular damage comprised 20% of all cases. In addition, the survival curves of the IgAN cases coincided with those of FGS and benign nephrosclerosis (BNS) with a similar extent of glomerular damages. On the other hand, glomerular damage mostly occurred due to intra- and intercapillary cell infiltration; poststreptococcal GN (AGN), lupus N, Cat. III a IV a and IV b, and MCIgAN all had a favorable outcome (follow-up mean: 12.4 +/- 6.7 yrs). More than 50% of the dialized patients came from both IgAN, focal type with hypertension, and IgAN with more than moderate glomerular damage regardless hypertension. The incidences of AGN, MPGN, HBvN have all decreased at the present time, while renal amyloidosis and crescentic glomerulonephritis (Cres. GN) have increased in number and this is reflected by the increased number of renal biopsies in elderly men. Glomerular deterioration is thus considered to be caused more by non-immunologic and hemodynamic injuries than by immune-derived, repeated inflammation, in human chronic glomerulonephritis(-pathy).
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PMID:[Histopathology of the biopsied kidney and its related glomerular deterioration]. 760 25


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