Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Osteoporosis, diabetes and hypertension are common concurrent chronic disorders. This study aimed to explore the respective effect of angiotensin II (Ang II) and angiotensin(1-7) [Ang(1-7)], active peptides in the renin-angiotensin system, on osteoblasts and osteoclasts under high glucose, as well as to investigate the osteo-preservative effects of Ang II type 1 receptor (AT1R) blocker and Ang(1-7) in diabetic spontaneously hypertensive rats (SHR). Ang II and Ang(1-7) respectively decreased and increased the formation of calcified nodules and ALP activity in MC3T3-E1 cells under high glucose, and respectively stimulated and inhibited the number of matured osteoclasts and pit resorptive area in RANKL-induced bone marrow macrophages. Olmesartan and Mas receptor antagonist A779 could abolish those effects. Ang II and Ang(1-7) respectively down-regulated and up-regulated the expressions of osteogenesis factors in MC3T3-E1 cells. Ang II promoted the expressions of cathepsin K and MMP9 in RAW 264.7 cells, while Ang(1-7) repressed these osteoclastogenesis factors. Ang II rapidly increased the phosphorylation of Akt and p38 in RAW 264.7 cells, whereas Ang(1-7) markedly reduced the phosphorylation of p38 and ERK under high glucose. After treatments of diabetic SHR with valsartan and Ang(1-7), a significant increase in trabecular bone area, BMD and mechanical strength was only found in the Ang(1-7)-treated group. Treatment with Ang(1-7) significantly suppressed the increase in renin expression and Ang II content in the bone of SHR. Taken together, Ang II/AT1R and Ang(1-7)/Mas distinctly regulated the differentiation and functions of osteoblasts and osteoclasts upon exposure to high glucose. Ang(1-7) could protect SHR from diabetes-induced osteoporosis.
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PMID:Differential responses of bone to angiotensin II and angiotensin(1-7): beneficial effects of Ang(1-7) on bone with exposure to high glucose. 3310 51


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