Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to approach long-term efficacy of percutaneous transluminal coronary angioplasty (PTCA) and the factors affecting its efficacy in Chinese patients, 229 patients who underwent successful PTCA in this institution were followed by direct interview or letters. The rate of follow-up was 95% for the patients who should be followed. The period of follow-up was 0.5-8.4 (mean 2.3 +/- 1.8) years. Angina pectoris recurred in 76 (33.2%) of the patients. In 76% of the patients with recurrence, angina developed within 6 months after PTCA. Cox regression analysis revealed that the relative risk of recurrence of angina pectoris was increased among the patients with triple vessel disease and hypertension. During the period of follow-up, 2 (0.9%) patients died, 6 (2.6%) had non-fatal acute myocardial infarction, 4 (1.7%) had coronary artery bypass graft surgery, and 29 (12.7%) had repeat PTCA. The cardiac event free survival rate calculated by Kaplan-Meier method was 84.8% at 1 year and 70.5% at 8 years. Cox regression analysis revealed that there were positive correlations between stenosis of lesions before PTCA and residual stenosis of LAD after PTCA and the relative risks of cardiac events. In conclusion, the long-term efficacy of PTCA in Chinese patients was good. We suggest that to decrease the residual stenosis of LAD during procedure could probably decrease the relative risk of cardiac events during follow-up.
Zhonghua Nei Ke Za Zhi 1996 Dec
PMID:[Long-term prognosis of percutaneous transluminal coronary angioplasty in 229 cases]. 959 7

The health status of 623 elderly people aged 60 years and over in different residential areas of Beijing was investigated. Among them 289 lived in the Xuanwu district, an urban area, 194 lived in a suburb area of Beijing, the Daxing county and 140 lived in a mountain area of the Huairou county. It was found that the prevalence rates of overweight (BMI 24-27) and obesity (BMI > or = 28), hyperlipidemia and diabetes in urban residents were much higher than that in the suburb and mountain residents (P < 0.01 and 0.05, respectively). The rate of obesity is higher in female than in male (P < 0.05). The rates of overweight and obesity decreased with increase of age (P < 0.001). In subjects with overweight and obesity the rates of hyperlipidemia, hypertension and diabetes were higher than those in the subjects without (P < 0.001). The detected rates of coronary heart disease and calcified valvular heart disease between the four groups with different body weight did not differ significantly.
Zhonghua Nei Ke Za Zhi 1997
PMID:[The investigation of risk factors of cardiovascular diseases in elderly people in Beijing]. 981 55

In this single blind, randomized multiple center clinical trial, the patients care period was divided into two stages. In the first stage (1985, 1-1989, 12), 984 cases were observed for 5 years whereas in the second stage (1990, 1-1994, 12), 2080 cases were observed and were subdivided into two groups, treat group and control, both were followed up for 5 years. The results showed that the prevalence of hypertension increased gradually. In the second stage, the average of blood pressure of the treatment group, using nitrendipine, was lower than that of the control group. There was significant difference between the two groups (P < 0.05). In the treatment group, the stroke and death rates were also decreased significantly as compared with the control group and the first stage group (P < 0.01).
Zhonghua Nei Ke Za Zhi 1997 May
PMID:[Prevention and treatment of stroke after hypertension for ten years in Hunan Province]. 1037 72

The coexistence of multiple cardiovascular risk factors in the same individual is called a clustering of cardiovascular risk factors. Many studies have shown that this phenomenoa is associated with a increased morbility of cardiovascular disease, and insulin resistance may be the common link between the risk factors. This study was designed to link the clustering of cardiovascular risk factors with insulin resistance. Using a new insulin sensitivity index [-log (fasting serum Glu x Ins)] to evaluate the insulin resistance, we investigated the relationship between the insulin sensitivity and cardiovascular risk factors in 106 patients with hypertension or coronary heart disease and 32 normal subjects. The normal group without cardiovascular risk factors was selected as controls. The individual with 2 risk factors were defined as having mild clustering, and those with > or = 3 risk factors as severe clustering. As the number of risk factors increased from 1 to > or = 3, the insulin sensitivity index increased from -1.69 +/- 0.24, -1.95 +/- 0.17 to -2.14 +/- 0.21 respectively. The insulin resistance was positively correlated with serum uric acid in women (P < 0.05), but not in men (P > 0.05). The insulin sensitivity was more decreased in postmenopausal than in pre-menopausal women. The insulin sensitivity index was -2.23 +/- 0.39 vs -1.73 +/- 0.13 (P < 0.05). The insulin resistance is associated with a clustering of risk factors of cardiovascular disease, more cluste-ring, more resistant.
Zhonghua Nei Ke Za Zhi 1997 Apr
PMID:[The role of insulin resistance in the clustering of cardiovascular risk factors]. 1037 88

We studied the prevalence of diabetes and impaired glucose tolerance (IGT) and their risk factors in the population of China. It was a population-based, cross-sectional study of 224,251 residents aged 25 years and over in 19 provinces and areas, including cities and rural areas of the North, South, East, West and central China. Using 1985 WHO criteria, We found the prevalence of diabetes and IGT were 2.51% and 3.20% respectively in 213,515 subjects aged 25 to 64 years. 70.33% of the subjects had newly recognised diabetes. The prevalence of diabetes in China is about 3 times higher than it was ten years ago, and the rate is increasing faster in the countryside than in cities. On average, subjects with diabetes are older, have higher personal annual incomes, and have more frequently a family history of diabetes. They also have higher mean body mass index (BMI), ratio of circumference of the waist to hip, systolic blood pressure, diastolic blood pressure and a greater prevalence of hypertension. They perform less physical activity and receive less education than persons with normal OGTT. Multiple logistic, stepwise regression analysis shows that age, BMI (or WHR), family history of diabetes, hypertension, less physical activity and higher annual income are independent risk factors of NIDDM, and that low education is also an independent risk factor of NIDDM in people with higher personal annual income.
Zhonghua Nei Ke Za Zhi 1997 Jun
PMID:[Prevalence of diabetes and its risk factors in China 1994. National Diabetes Prevention and Control Cooperative Group]. 1037 97

To understand of fibronectin (Fn) distribution in kidney of IgA nephropathy (IgAN) and their meaning, we studied 107 cases of IgAN. Strong positive staining of Fn was shown in mesangial areas with proliferation, crescents, segmental sclerosis, and sclerosing glomeruli. 33 patients (group M) had Fn distributed only in mesangium, and 74 (group B) had Fn along the capillary walls as well as mesangium. Compared with those in group M, patients in group B showed more severe renal histological lesions (P < 0.01), crescent formation and stronger staining of IgG, C3 (P < 0.05) and IgA (P < 0.01) along the capillary walls. More severe changes of GBM were found in group B under electron microscopy. Clinically, 24th protein excretion (P < 0.01), incidences of hypertension and nonselective proteinuria were significantly higher (0.01 < P < 0.05), and Ccr was lower (0.01 < P < 0.05) in group B. 44 patients were followed up for 19.2 months, and the incidence of renal function deterioration in group B increased much more (0.01 < P < 0.05) than that in group M. Our results dmonstrated that the increase of Fn along the golmerular capillary walls might reflect that excessive proliferation of mesangial matrix, severe immune injury in capillary wall and damage of GBM, which are correlated with unfavorable clinical features and progression of the disease.
Zhonghua Nei Ke Za Zhi 1997 Jun
PMID:[Distribution of fibronectin in kidney of IgA nephropathy and its clinicopathological correlation]. 1037 98

We studied the relationship between the urinary microtransferrin (TRF) and early glomerular damage in diabetes mellitus. 61 patients with non-insulin-dependent diabetes mellitus and 40 healthy subjects were measured for urinary TRF with rate immunonephelometry assay. The Urinary TRF concentrations were found to be greatly elevated in patients with diabetes compared with those in the health subjects (P < 0.001). The increase of TRF was closely related to age and duration of diabetes mellitus, blood glucose, hypertension, retinopathy, and it was initial parameter to predict diabetic nephropathy. There was a significant correlation among urinary TRF concentration, microalbumin, and N-acetyl-beta-D-glucosaminidase. The urinary excretion of TRF was more elevated than that of microalbumin. It is suggested that excretion of TRF in urine is a more sensitive index of the glomerular dysfunction in diabetes mellitus.
Zhonghua Nei Ke Za Zhi 1997 Mar
PMID:[Clinical significance of microtransferrinuria in diabetic patients]. 1037 8

Recent clinical studies showed that an independent association between hyper-insulinaemia and coronary heart disease (CHD) in men with normal glucose tolerance. In non-insulin-dependent diabetes mellitus (NIDDM) it is less clear. Therefore, we evaluated insulin-sensitivity index, plasma glucose, insulin, lipoproteins and apolipoproteins in 40 male NIDDM patients with CHD, and compared them with 36 male NIDDM patients without CHD. The insulin-sensitivity index determined by the reverse of fasting plasma glucose and insulin product. The results showed that the subjects with CHD had significantly lower insulin-sensitivity index (P < 0.01) compared to those without CHD. Using step-wise logistic regression analgsis, we found insulin-sensitivity indexes (OR 0.237, 95%CI 0.0909-0.6167, P = 0.0032) were negatively associated with CHD, and were independent from other cardiovascular risk factors such as age, body mass index, hypertension, and hyperlipemia. We conclude that in NIDDM patients with CHD are more insulin resistant compared to those without CHD. Insulin resistance is associated with CHD, and independent from other cardiovascular risk factors.
Zhonghua Nei Ke Za Zhi 1997 Mar
PMID:[Relationship between insulin resistance and coronary heart disease in non-insulin-dependent diabetes mellitus patients]. 1037 10

We investigated the change of 24 hours ambulatory blood pressure (ABPM) in impaired glucose tolerance (IGT) patients. 40 IGT patients were divided into two group: normotension and hypertension groups. Each group was matched with normal glucose tolerance (NGT) and non-insulin-dependent diabetes mellitus (NIDDM) group. All the patients were subjected to ABPM and biochemical index examination. The profile of ABPM in IGT patients with or without hypertension was investigated. The change of the 24 hours blood pressure in both normotensive and hypertensive IGT patients was similar with NGT, but there was a tendency that night blood pressure was increased and nocturnal blood pressure was decreased in IGT. The change of ABPM in those with abnormal circadian rhythm was elevated night blood pressure.
Zhonghua Nei Ke Za Zhi 1997 Aug
PMID:[24 hours ambulatory blood pressure in impaired glucose tolerance patients]. 1043 60

To disclose the prevalence of thin membrane nephropathy (TMN) in China and its clinical and pathological features, we prospectively studied TMN cases including 722 cases of renal biopsies in 2 years. 27 cases (male 7 cases, female 20) were diagnosed as primary glomerulonephritis. The GBM thicknesses of TMN group (n = 27) and control group (n = 32) was 207 +/- 36 nm and 382 +/- 34 nm (P < 0.01) respectively. IF of TMN was negative or trace, near normal morphology or mild mesangial proliferative glomerulo nephritis was observed by LM. A few of them had global glomerular sclerosis or single crescent formation. All TMN patients had microscopic hematuria. About one third (9/27 cases) patients with TMN presented isolated persistent microscopic hemataria, 44.4% (12/27 cases) and 22.2% (6/27 cases) patients with TMN were accompanied with mildmoderate proteinuria and heavy proteinuria (> or = 3.5 g/24 h) or nephrotic syndrome. The patients with heavy proteinuria or nephrotic syndrome had good response to corticosteroid therapy. All patients with TMN had normal renal function, only a few of them had transient hypertension. The results showed that the prognosis of TMN would be regarded as good. The familial history of 15 patients with TMN was investigated, and 47% (7/15 cases) of them had > or = two members with microscopic hematuria in their families. TMN was found in 3.7% (27/722 cases) in total renal biopsies and 11.5% (9/78 cases) in the patients with isolated microscopic hematuria. It suggests that TMN isn't a rare kidney disease in China. Careful EM is a critical method for the correct diagnosis of TMN.
Zhonghua Nei Ke Za Zhi 1997 Nov
PMID:[Thin membrane nephropathy: 27 cases]. 1045 44


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