Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Plasma atrial natriuretic peptide (ANP) was measured with radioimmunoassay in 39 patients with acute stroke. The mean level was 144.3 +/- 8.7 pg/ml; this was significantly higher in comparison with those in normal controls (55.8 +/- 4.7 pg/ml, n = 20) and hypertension patients (87.7 +/- 8.0 pg/ml, n = 15). Serial measurement of ANP level in 6 patients showed that it was elevated on the first day of the stroke, reached to its peak on the second or third day and returned to normal after two weeks. Five patients had hyponatremia following the attack of stroke and the plasma ANP level was further elevated. It is suggested that elevated plasma ANP level might be a pathogenetic factor of the accompanying hyponatremia in stroke.
Zhonghua Nei Ke Za Zhi 1993 Feb
PMID:[Increased concentration of plasma atrial natriuretic peptide in patients with acute stroke and its significance]. 840 32

Four cases of fibrillary glomerulopathy (FGP) were reported for the first time in China. All patients had proteinuria, microscopic hematuria and hypertension. Renal function deteriorated in 2 cases. Pathological findings in light microscopy were sever: MPGN (2 cases), MN (1 case) and MsPGN (1 case). Congo-red stain of renal specimens was negative in all of them. Immunofluoscence (IF) in most of the cases (3/4 cases) showed granular IgG and C3 deposits in mesangium and glomerular basement membrane (GBM). Electron microscopy (EM) showed rich of fibrils distributed randomly over mesangium and GBM, the diameter of fibrils was 20.50 +/- 0.37nm. The diagnosis of FGP depends on EM examination. The actual incidence of FGP in China needs further studies.
Zhonghua Nei Ke Za Zhi 1995 Jun
PMID:[Clinical and pathological analysis of fibrillary glomerulopathy]. 858 80

Adult polycystic kidney disease (APKD) is a common genetic disease and one of the important reasons of end stage renal failure. Although renal multiple cysts are clearly an important manifestation of APKD; other systemic manifestations are both common and clinically important. The authors reviewed 205 cases from 180 APKD families (107 male 98 female). Their age ranged from 10 to 71 years. Renal cyst is one of the many renal manifestations. Hypertension, hematuria and flank pain are its major complications. Hepatic cysts, pancreatic cysts, cardiac valvular lesions, intracranial aneurysms and splenic cysts are included in the array of systemic manifestations.
Zhonghua Nei Ke Za Zhi 1995 Sep
PMID:[Systemic manifestations of adult polycystic kidney disease: an analysis of 205 cases]. 869 29

A prospective randomized study to compare the efficacy between plasma exchange (PE) plus D-penicillamine (13 cases) (group I) and D-penicillamine alone (16 cases) (group II) in the treatment of diffuse scleroderma was carried out. Total skin score, the distance between finger and palm, the distance between upper and lower teeth, the index of joint tenderness, grip strength, ESR, IgG, plasma renin and angiotensin II were measured. After 6 times of PE, all parameters in group I showed significant improvement as compared with those before treatment (P < 0.05-P < 0.01). The overall effective rates evaluated by physicians and by patients were 61.1% and 69.2% respectively. One and half year after the 6 times of PE, all parameters in group I were lower than those in group II (P < 0.05). In group I there were less internal organ impairment and hypertension than in group II. The commonest side effect of PE was hypotension; it disappeared after transfusion.
Zhonghua Nei Ke Za Zhi 1995 Sep
PMID:[A prospective study of plasma exchange in the treatment of diffuse scleroderma]. 869 30

To study the relationship between plasma insulin level, sodium sensitivity and blood pressure, 150 children aged from 10 to 15 years with high blood pressure and 150 children matched for age and sex but with normal blood pressure were measured for plasma insulin with radioimmunoassay and sodium sensitivity with the tests of oral saline load and furosemide sodium-volume depletion and followed for 5 years. The results showed that (1) In children with HBP and positive family history of hypertension (FH+), the plasma insulin level was significantly higher than that in the respective control group (P < 0.01); (2) In children with high plasma insulin level, the percentiles of systolic blood pressure kept high and had a rising tendency during the follow-up period; (3) In children with sodium sensitivity, the plasma insulin level was higher than that in children with sodium resistance (P < 0.01) and the plasma insulin level correlated positively with blood pressure increasing rate of post-load (P < 0.05). It is suggested that insulin resistance was associated with sodium sensitivity, and they might play a role in the development of hypertension in childhood.
Zhonghua Nei Ke Za Zhi 1995 Nov
PMID:[Association of plasma insulin with blood pressure and sodium sensitivity in children]. 873 45

Clinical and angiographic characteristics of renovascular hypertension were studied in 95 patients. The patients were divided into 3 groups: 55 cases with aortic arteritis (group AA), 27 with fibromuscular dysplasia (group FMD) and 9 with atherosclerosis (group AS). The patients in group AS were significantly older in age and had longer history of hypertension. Abdominal bruit was heard significantly more often in group AA and serum potassium was significantly lower in group FMD. Angiographic data showed that in group AA lesions in thoracic aorta and abdominal aorta was found in 81.4% and those involving both renal arteries in 52.5%. In group FMD, 82.5% of patients had lesion in renal artery on one side and none had lesion in thoracic and abdominal aorta. In group AS, lesions were found mainly in thoracic and abdominal aorta, accounting for 77.7% and lesions in renal arteries were mainly unilateral. In group AA, lesions were found in 90 renal arteries altogether. Among them, 58.9% was in the proximal part of the renal artery; the lesion was either localized stenosis (67.8%) or obstruction (17.7%). In group FMD, lesions were found in 33 renal arteries altogether. Among them, 48.5% was in the middle or distal part of the renal artery and 27.3% resembled string of beads. In group AS, a total of 10 renal arteries were involved with 4 (40%) of ostial stenosis and 4 (40%) total obstruction.
Zhonghua Nei Ke Za Zhi 1995 Nov
PMID:[Clinical and angiographic characteristics of renovascular hypertension]. 873 48

To assess the prevalence of extracranial carotid artery atherosclerosis and its relation to principal cardiovascular risk factors in Chinese elderly patients, 100 cases aged from 54 to 94 were investigated with B-mode ultrasonography. Arterial intima-media thickening, plaque, mild stenosis (defined as a plaque that obstructed > 20% of the lumen diameter), and clinically significant stenosis (> 50% in cross-sectional area) were found in 79, 49, 40 and 3 patients, respectively. There was no significant correlation between carotid atherosclerosis and coronary heart disease, cerebral infarction, hypertension, hyperlipidemia or diabetes. In contrast, the prevalence of carotid atherosclerosis was increased with age (P < 0.05), so did the severity. Thus, age is a major risk factor for carotid atherosclerosis in the elderly.
Zhonghua Nei Ke Za Zhi 1996 Jan
PMID:[The prevalence and risk factors of carotid atherosclerosis in elderly patients]. 927 42

5 cases with obesity-hypoventilaion syndrome were reported. The clinical manifestations were obesity, palpitation, dyspnea, lethargy, cyanosis, distention of cervical vein, edema, enlargement of liver and hypertension. All of them were initially diagnosed as chronic bronchitis or heart diseases. Pulmonary function test showed restrictive ventilative defect and hypercapnia with hypoxemia. Mouth oclusion pressure at 0.1 second was higher than the normal value. The response to CO2 was decreased. Hypertrophy of right heart was shown in ECG and X-ray film improvement in symptoms and blood gases analyses were found to be associated with body weight decrease in a follow up period of one year.
Zhonghua Nei Ke Za Zhi 1996 Jan
PMID:[Obesity-hypoventilation syndrome]. 927 46

The prevalence and risk factors of hypertension and coronary heart disease (CHD) in subjects with abnormal glucose metabolism (AGM) were studied in a population of 29,960 in the Capital Iron and Steel Corporation. The results showed that the prevalences of hypertension and CHD were 37.37% and 9.32% in diabetes group and 29.88% and 6.25% in impaired glucose tolerance group respectively. Both aging and obesity were the risk factors for AGM, hypertension and CHD. Hyperglycemia and hyperlipidemia were related to the occurrence of hypertension and CHD. Our results indicate that the prevalence of CHD and hypertension is significantly increased in AGM subjects, and they have many other risk factors of cardiovascular disease.
Zhonghua Nei Ke Za Zhi 1996 May
PMID:[Prevalence and risk factors of hypertension and coronary heart disease in the subjects with abnormal glucose metabolism]. 938 13

To study the relationship of the concentration of serum lipoprotein (a) [Lp(a)] with diabetic complications in non-insulin dependent diabetes mellitus (NIDDM), 100 non-diabetics with 150 patients with NIDDM were compared. There was no difference in Lp(a) concentration (P > 0.5) between the two groups. Lp(a) concentration was not significantly correlated with the levels of total cholesterol, low-density lipoprotein cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), HDL2-C, HDL3-C, apolipoprotein A-I, apolipoprotein B in both groups. In NIDDM group, patients with hypertension, macro- and microangiopathy had higher levels of Lp(a) than those without these complications (P < 0.001 and P = 0.002 respectively). Lp(a) level was positively related to presence of macroangiopathy (r = 0.185, P = 0.024) and proteinuria (r = 0.316, P < 0.001) in NIDDM.
Zhonghua Nei Ke Za Zhi 1996 Apr
PMID:[Lipoprotein (a) and non-insulin dependent diabetes mellitus]. 938 40


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