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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Several erythrocyte biophysical properties (erythrocyte deformability, erythrocyte aggregation and erythrocyte electrophoretic mobility) were investigated in patients with cerebral infarction and in individuals with risk factors of stroke (RFS population; RFSP). Blood viscosity, plasma viscosity, hematocrit, plasma fibrinogen level and yield shear stress (YSS) were also tested. In comparison with the results in a control group, erythrocyte deformability (erythrocyte length under a certain constant shear stress and erythrocyte filterability) was less in both the patient group and the group of RFSP and there is an accompanying increase of erythrocyte aggregation. Blood viscosity and fibrinogen level were higher in the patient groups. There was no correlation between erythrocyte deformability and other hemorheological parameters. Our results suggest that significant alteration of erythrocyte biophysical properties may be implicated in the pathogenesis of ischemic stroke. These abnormalities are associated with some of the risk factors of stroke such as hypertension, atherosclerosis and cardiovascular disorders.
Zhonghua Nei Ke Za Zhi 1991 Dec
PMID:[Alteration of erythrocyte biophysical properties in patients with ischemic cerebrovascular disorders]. 181 80

We investigated lipoprotein profile of 18 non-dialysis patients with CRF and 17 patients on hemodialysis, and studied effect of LPD plus EAA on lipid metabolism of 18 non-dialysis patients with CRF. The results revealed that total triglyceride, cholesterol, LDL, VLDL, and semi-quantity of ApoCII, ApoCIII were significantly increased, and HDL, ApoAI ApoAI/ApoB rate, semiquantify of ApoCI were significantly reduced in non-dialysis patients and patients on hemodialysis; VLDL and Ccr were closely negative related in non-dialysis patients. The lipid abnormalities were more severe in non-dialysis patients complicated with hypertension than without hypertension. After 6 to 10 weeks' LPD plus EAA treatment in 18 non-dialysis patients, total triglyceride, cholesterol, LDL, VLDL were significantly reduced, and HDL, ApoAI, ApoAI/ApoB were significantly increased. We conclude that it is characterized by type IV hyperlipidemia in lipid abnormalities of patients with CRF, and LPD plus EAA treatment may improve it effectively.
Zhonghua Nei Ke Za Zhi 1991 Feb
PMID:[Effect of low protein diet, plus essential amino acids on lipid metabolism in patients with chronic renal failure]. 186 71

In order to know the incidence and character of rapidly progressive glomerulonephritis (RPGN) in China, 20 patients with RPGN were analysed and 10 of them followed. Their diagnosis were confirmed by biopsy showing extensive crescent formation. Five patients were rebiopsied. RPGN was found in about 3% of the patients with glomerulonephritis in our center. Only one case was mediated by anti-GBM antibody, while the other 19 by immune complex. Prodromal infection was common (12/20). Hematuria, nephrotic syndrome and hypertension were found in 20, 15 and 12 patients respectively. Five patients without special treatment died of renal cause within 6 months. Intensive treatment (pulse methylprednisone or plasmapheresis) was effective in all of the four cases with cellular crescents. After the treatment, their renal function improved with decrease of proliferation and crescent formation as shown by rebiopsy. However, deterioration of renal function reappeared after 3 months to 3 years in three of the cases. It is shown that in China, RPGN was predominantly mediated by immune complex and is associated with a high incidence of prodromal infection. Clinically, nephrotic syndrome was more frequently seen here than in western countries. For improvement of the prognosis, it is necessary to pay attention not only to earlier diagnosis but also to protection of renal function after intensive therapy.
Zhonghua Nei Ke Za Zhi 1991 Apr
PMID:[Diagnosis and treatment of rapidly progressive glomerulonephritis. An analysis of 20 cases]. 187 90

Calcitonin gene-related peptide (CGRP) is a 37-amine acid bioactive polypeptide and known to be a powerful vascular relaxant. CGRP was measured in 45 cases with essential hypertension (EH). The results suggested that plasma CGRP level in patients with EH was lower than that in normal subjects (P less than 0.001). It was found that decrease of plasma CGRP was closely related with the severity of hypertension. However, the level of plasma atrial natriuretic factor (ANF) in EH patients was significantly increased as compared with normal subjects (P less than 0.01). A negative correlation between plasma CGRP and ANF (r = -0.3615, P less than 0.02) was found. These data suggested that decrease of plasma CGRP may play an important role in the pathogenesis of hypertension.
Zhonghua Nei Ke Za Zhi 1990 Oct
PMID:[Plasma calcitonin gene-related peptide (CGRP) level in patients with essential hypertension]. 215 Jul 97

Determination of serum endogenous digitalis-like factor (EDF) concentration was carried out in 52 patients with chronic congestive heart failure with radioimmunoassay. The results showed that concentration of serum EDF in patients with chronic congestive heart failure was significantly lower than that in normal subjects (P less than 0.001). The lowering of serum EDF concentration was significantly negatively correlated with the severity of heart failure, r = 0.6475, P less than 0.001. Age had no significant effect on serum EDF concentration (P greater than 0.05). Serum EDF concentration rose after the heart failure was treated, but was still lower than that in normal subjects (P less than 0.01). Serum EDF concentration in patients with coronary heart disease was the lowest and in patients with hypertension the highest.
Zhonghua Nei Ke Za Zhi 1990 Jan
PMID:[Clinical significance of changes in the serum level of endogenous digitalis-like factor in patients with chronic congestive heart failure]. 216 87

The prognostic factors in the acute stage of 893 myocardial infarction patients, admitted during a period from 1970 to 1986, were analysed. The overall mortality was 15.6%, including 14.4% cardiac death and 1.1% non-cardiac death. Single factor analysis indicated that age, sex, occupation, history of hypertension, chest pain during the episode, systolic blood pressure, heart rate and site of infarction at the time of admission, presence of complications such as cardiogenic shock, arrhythmias, stroke and monitoring in CCU or not were related to the overall mortality and cardiac death. Multiple factor logistic regression analysis indicated that for the overall mortality, the independent prognostic factors included presence of cardiogenic shock, heart rate and chest pain at the time of admission; for the cardiac death, the independent factors included age, occupation, history of hypertension, heart rate and chest pain at the time of admission, involvement of anterior wall and presence of cardiogenic shock and arrhythmias. Basing on the above findings we establish a risk factors predicting prognostic model of acute myocardial infarction in its acute stage.
Zhonghua Nei Ke Za Zhi 1990 Mar
PMID:[Prognostic factors in the acute stage of myocardial infarction: analysis of 893 cases]. 220 38

The hypercoagulable state in patients with diabetes mellitus, glomerular diseases and pregnancy induced hypertension was studied by using new methods. The research items included platelet function, coagulation, anti-coagulation system, fibrinolysis and TEG examination. The results showed that there was a hypercoagulable state in patients with diabetes mellitus, pregnancy induced hypertension and glomerular diseases, especially in those with uremia and nephrotic syndrome.
Zhonghua Nei Ke Za Zhi 1990 Jul
PMID:[Clinical research of hypercoagulation in patients with diabetes mellitus, glomerular diseases and pregnancy induced hypertension]. 228 69

The effect of EPA enriched marine oil on platelet function in 12 cases of hypertension, 15 cases of diabetes and 20 cases of coronary heart disease is reported. The result of our study showed that there was platelet hyperfunction of various degrees in patients with those three kinds of diseases. The murine oil had an effect of inhibition, which were manifested by the prolongation on bleeding time, and decreased on platelet adhesion and aggregation. TxB2 in plasma was reduced, while 6-keto-PGF increased. There was no influence of EPA enriched fish oil on blood sugar and liver or kidney function. The authors concluded that platelet hyperfunction is an important element in the development of cardio vascular and cerebro vascular complications and increases the mortality rates in these diseases. Treatment with such a drug has beneficial effect with clinical improvement.
Zhonghua Nei Ke Za Zhi 1990 Jul
PMID:[The effect of eicosapentaenoic acid enriched marine oil on the platelet function in hypercoagulable state]. 228 70

To investigate the relationship between renin-angiotensin-aldosterone system and pulmonary hemodynamic parameters in patients with chronic pulmonary artery hypertension, we measured plasma levels of renin activity, angiotensin II and aldosterone in 11 patients during right heart catheterization. All patients had chronic obstructive pulmonary disease. At rest, plasma concentration of angiotensin II positively correlated with mean pulmonary artery pressure (r = 0.76, P less than 0.01) and pulmonary vascular resistance (r = 0.64, P less than 0.05). During exercise, plasma level of angiotensin II increased from 70 +/- 21 to 81 +/- 24 pg/ml (P less than 0.01) and plasma renin activity from 0.66 +/- 0.54 to 1.28 +/- 1.2 ng/ml/h (P less than 0.05), whereas mean pulmonary artery pressure increased from 3.73 +/- 0.85 to 6.27 +/- 1.81 kPa (28 +/- 6.4 to 47 +/- 13.6 mmHg). Increase of angiotensin II correlated with changes in mean pulmonary artery pressure (r = 0.69, P less than 0.05) but not with systemic artery pressure. The results of present study suggest that angiotensin II might play a role in the development of pulmonary artery hypertension in patients with chronic obstructive pulmonary disease.
Zhonghua Nei Ke Za Zhi 1990 Jul
PMID:[Renin-angiotensin-aldosterone system and pulmonary hemodynamics in patients with pulmonary artery hypertension]. 228 76

The clinical classification and characteristics of various types of plateau sickness were reported after analysing 13,403 such cases in Tibet region. The conception of plateau sickness and the opinion of its classification in China and abroad were discussed and the names suggested for various types of the disease were also given. However, the rationality of different classifications of the sickness was questioned according to the present understanding of its pathology and clinical manifestations. It is the opinion of the authors to divide this sickness, first of all, into two categories of acute and chronic and then to subdivide each of them into several types according to clinical symptoms and the pathological changes of principally encroached organs. The acute category was subdivided into 4 types as follows: 1. high altitude acute response (HAAR); 2. high altitude pulmonary edema (HAPE); 3. high altitude cerebral edema (HACE); 4. high altitude children cardiopathy (HACC). The chronic category was subdivided into 5 types as follows: 1. high altitude chronic response (HACR); 2. high altitude erythoblastosis (HAEb); 3. high altitude adult cardiopathy (HAAC); 4. high altitude hypertension (HAHyper); 5. high altitude hypotension (HAHypo). This classification is useful in clinical practice and research.
Zhonghua Nei Ke Za Zhi 1990 Jan
PMID:[Clinical classification of altitude sickness: analysis of 13,403 cases]. 240 Nov 67


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