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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Comparative study was performed on the Heart-Qi Deficiency and Blood Stasis type (HQDBS) of hypertensive patients treated with Qigong. The results showed that the clinical symptoms alleviated, cardiac morphology and function, hemorheology and erythrocyte deformity were improved. After one year of practicing Qigong, plasma histofibrinogen activation inhibitor (PAI) and VIII factor related antigen (VIII R: Ag) levels decreased, while plasma tissue fibrinolytic activator (t-PA) and anti-thrombogen III (AT-III) levels increased. Capillary blood velocity of nailfold microcirculation raised from 0.2940 +/- 0.0206 mm/s to 0.3045 +/- 0.0236 mm/s, the diameter and length of afferent limb tended to increase. The above data indicated that Qigong could benefit HQDBS. This might be the mechanism by which HQDBS type of hypertension was treated.
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PMID:[Effect of qigong on heart-qi deficiency and blood stasis type of hypertension and its mechanism]. 858 Jun 89

Clinical features of the anterior inferior cerebellar artery (AICA) territory infarcts were investigated in ten patients, ranging in age from 38 to 76 years. In all patients, there were MR images of infarction located in the area supplied by the AICA. The lesion was on the left side in 6 patients and right side in 4. The lesion of brain stem including the middle cerebellar peduncle was found in 7 patients and that extended to the cerebellum was in 3 patients. The main ipsilateral neurological signs were the VII and VIII cranial nerves palsy and cerebellar ataxia. The V and VI cranial nerves palsy. Horner's syndrome, and dysphagia were also present. The main contralateral sign was superficial sensory disturbance, but no hemiplegia. The underlying pathology included chiefly hyperlipidemia, hypertension, and diabetes mellitus. Cerebral angiography was performed in 8 patients, most of which was observed severe arteriosclerosis suggesting poor hemodynamics in the vertebral and basilar arteries. The prognosis was relatively good, but the VII, VIII, and V cranial nerves palsy and contralateral superficial sensory disturbance remained as the sequelae. As mentioned above, there were various neurological findings and MR images in AICA territory infarcts. Especially there were some patients whose lesion extended to the upper medulla and neurological findings were similar to the Wallenberg syndrome. It is important that one investigates not only axial slices but also coronal slices of MR image to estimate the extension of AICA territory infarct.
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PMID:[Clinical features of anterior inferior cerebellar artery territory infarcts--a study of ten patients]. 904 27

Four patients, 3 woman and 1 man, with giant petroclival meningiomata are presented. In all cases the tumor size exceed 44 mm in its greater diametre. Main clinical symptoms were endocranial hypertension and cranial nerves deficit. A modified transcochlear approach in two stages was used. A total petrosectomy was performed, using the petrosygmoidal via for opening the dura. Transversus and sygmoid sinus were spared. Total removal was achieved in 2 cases, subtotal and partly in each of the other 2. No operative mortality occurred (hospital exitus) and neurologic morbility related to V-VI-VII and VIII cranial nerves and 1 hemyparesia was recorded. The AA. explain and comment the fundamentals of the followed procedure and compare, as well, the own outcomes with those reported by more classic alternatives. Finally, the conclusion is drawn out that retroclival meningiomata are conditions treatable, although always are difficulty approached and demand meticulous microsurgical techniques.
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PMID:[Petrous bone approach for the surgery of petroclival meningiomas]. 965 67

In this study 79 pregnant women were analyzed, during the pregnancy, delivery and postnatal period. The control group consisted of 41 healthy women, while in the studied group there were 38 patients with severe chronic hypertension. Analyzed parameters: fibrinogen, fibrinolysis and FDP. Parameters were performed in all cases of pregnancies during third trimester (I), during the first stage of labor (II), immediately after delivery of placenta (III), two hours after placenta was delivered (IV), eight hours (V), 24 hours (VI), 48 hours (VII) and 72 hours (VIII) after placenta was delivered. Comparing certain measures in fibrinogen's value, high statistical significance was obtained for control group (healthy women), ANOVA (F = 5.17; p < 0.001) and for studied group (women for chronic hypertension), (F = 3.17; p < 0.001. Analyses of FDP values showed high statistically significant difference for control group, F = 15.03; p < 0.00001, and for studied group, F = 10.56; p < 0.00001. Statistically significant difference in fibrinolytic activity was obtained for control group, F = 60.72; p < 0.0001 and studied group, F = 5.70; p < 0.0001.
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PMID:[Changes in fibrinogen, fibrin-fibrinogen degradation products and fibrinolytic activity during pregnancy, labor and the puerperium in pregnant women with chronic hypertension]. 1087 73

Hypertension is the most common medical complication of pregnancy in South Africa and a major cause of maternal and perinatal morbidity and mortality worldwide. At King Edward VIII Hospital in Durban, 18% of all admissions to the obstetric unit have some degree of high blood pressure. Hypertension in its most severe form produces convulsions, proteinuria, and edema and may lead to fetal and maternal death. High-risk groups for preeclampsia are teenage mothers, primigravidas, and women with a history of elevated blood pressure, previous preeclampsia, molar pregnancies, multiple pregnancies, or hydrops fetalis. Methods used to prevent preeclampsia include a low-salt diet supplemented with calcium, magnesium, zinc, fish, and pharmacological manipulation. In developing countries, prevention and detection of preeclampsia is difficult since women seek antenatal care late in their pregnancies. In Durban, the average gestational age at first antenatal attendance is 28 weeks, and 80% of patients presenting with eclampsia have defaulted antenatal care. Treatment includes admission to hospital to establish the etiology of the hypertension and maternal renal function tests . Fetal condition is a sensitive index of hypertension and is judged by 1) clinical evidence of fetal growth, 2) weekly antepartum cardiotocography, and 3) ultrasonographic screening. Patients are managed according to three clinical groups: 1) those identified before 36 weeks, 2) those identified after 36 weeks, and 3) patients in hypertensive crisis. Dihydralazine is the drug of choice for imminent eclampsia. If the patients has a ripe cervix, delivery is induced with 6-8 hours. Steroid contraception use in the older hypertensive patient should be avoided because of possible development of atherosclerosis and stroke. Puerperal tubal ligations in the hypertensive patient ought to be avoided because of the risks of thromboembolic phenomena and pulmonary embolism. Methyldopa is the treatment of choice in cases of moderate to severe hypertension. Intravenous dihydralazine is relatively safe for the rapid reduction of high blood pressure.
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PMID:Coping with hypertension in pregnancy. 1234 38

Long-term treatment with cyclosporine in solid organ transplantation has been shown to be associated with the development of hypertension and nephrotoxicity. Angiotensin-converting enzyme inhibitors have well-known nephroprotective properties and may prevent cyclosporine A (CYA)-induced hypertension. Angiotensin receptor 1 antagonists have similar properties. The purpose of this study was to investigate if losartan or enalapril could be administered with CYA to reduce its nephrotoxic effect in uremic rats. The studies were performed on the following groups of rats: group I--control; group II--control rats + losartan; group III--control rats + CYA; group IV uremic rats; group V--uremic rats + losartan; group VI--uremic rats + CYA; group VII--uremic rats + losartan + CYA, group VIII--control rats + enalapril; group IX--control rats + enalapril + CYA; group X - uremic rats + enalapril; group XI--uremic rats + enalapril + CYA. Pretreatment with CYA, losartan or enalapril in uremic rats resulted in a significant increase in urea and creatinine levels and a decrease in hematocrit. The same effect was observed when uremic rats were given CYA + losartan or CYA + enalapril. Pretreatment with losartan was associated with the increase in the level of CYA much higher than with CYA treatment alone. Similarly, pretreatment with enalapril resulted in a significant increase in CYA concentration in both groups of rats given CYA: uremic and non-uremic. Results of our study show that the treatment with cyclosporine and a combination of losartan or enalapril results in an increase in creatinine and urea levels and a decrease in hematocrit. Therefore, physicians should exercise caution, when they give losartan and enalapril to kidney allograft recipients treated with cyclosporine, particularly with impaired allograft function.
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PMID:Effects of combination of cyclosporine with losartan or enalapril on kidney function in uremic rats. 1259 33

Roentgen computed tomography (RCT) and MR-imaging (MRI) were used in investigation of vertigo etiology and affection of the cochleovestibular analyzer in 130 patients aged 28 to 74 years with recurrent systemic rotatory vertigo or its other symptoms. All the patients have undergone comprehensive otoneurological examination, RCT and MRI which showed that peripheral cochleovestibular syndromes (PCVS) caused by arterial hypertension (AH), atherosclerosis (AS), vascular dystonia (VD) are rarely characterized by focal alterations in the brain. PCVS comparison with blood flow in the vertebral arteries (VA) detected most frequently anomalies and asymmetries of the diameters. MR-angiography plays an important role in verification of pathology of intracranial VA. In central cochleovestibular syndrome (CCVS) with AH, AS, VD, principal pathological changes were registered in the brain trunk and cerebellum by MRI. Vestibulometry and otoneurological method detect not only vascular cochleovestibular peripheral and central syndromes but also to make differential diagnosis. RCT and MRI verify cochleovestibular syndromes in patients with multiple encephalomyelitis, VIII nerve neurinoma and tumors of the posterior cranial fossa.
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PMID:[The role of neurovisualization methods in diagnosis and verification of vertigo etiology]. 1648 4

To evaluate the association of inherited coagulopathies and acquired conditions (e.g. hypertension, aspirin use) with emergency department admission due to epistaxis. Patients admitted to the emergency department with epistaxis were included. A questionnaire for personal and family history of any bleeding disorder was used. Physical examination including ear, nose and throat examination was performed. Platelet counts, International Normalized Ratio, activated partial thromboplastin time, factors VIII, IX and XI, von Willebrand factor and ristocetin cofactor activity levels were determined. Nineteen patients were included in the study. Personal history of mucocutaneous bleeding was present in four cases and family history in two cases. Only one case (5%) had a decreased von Willebrand factor level (45%), and also had a personal and family history of bleeding tendency. Ten patients (53%) had a history of aspirin use. Thirteen (68%) patients had hypertensive values on admission. Aspirin use and hypertension were the leading causes of emergency service admission in adults due to epistaxis in this study, although the number of the patients was relatively low. Regarding the low prevalence of inherited coagulopathies, detailed coagulation tests should be reserved for adult patients with positive personal and/or family history of bleeding.
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PMID:Research for bleeding tendency in patients presenting with significant epistaxis. 1717 25

Patients with hypertension and ischemic heart disease develop oftener life threatening thromboembolic complications (ischemic stroke, myocardial infarction), which are conditioned by disorders in the system of blood hemostasis. Along with this, laboratory tests used in medicine are rather variable and not considered to assess risk factor and optimize the treatment individually. In the end of the last century we have developed a laboratory technology called "Co-aguloscop-TC" (the patent of Ukraine), which allows registering in blood 36 parameters of coagulation cascade and calculate two integral parameters which we have named modules of coagulation (MC) and fibrinolysis (MF). As these modules, especially MC reflect the character and degree (from 1 to X) of disorders of coagulation potential, in last studies these modules were used to identify intensity of hypercoagulation as the predictor of thrombus formation and detection of a hemostatic risk factor and calculation of individual doses of some antiaggregants. This article presents results of continuous monitoring (2-6 months) of parameters of blood hemostatic balance in two outpatients with stage II arterial hypertension. Obtained data showed that antiaggregants should be prescribed only after revealing hypercoagulation signs in individual doses depending on the severity of the MC and weight of a patient. At presence of a high risk factor relevant to the VI-VIII degree of hypercoagulation (the thrombosis develops at IX-X degree) it is necessary to use hypotension and antiatherogenic therapy together with parenteral use of antiaggregants (acelisinum, aspisolum) one time per day during 4-6 days).
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PMID:[Optimization of the treatment and prevention of thrombus formation in arterial hypertension]. 1866 39

Chemically induced dynamic nuclear polarization (CIDNP) and electron paramagnetic resonance (EPR) techniques have been used to study the paramagnetic species formed during the photolysis of the alkaloid lappaconitine and its synthetic analogues in solution. Lappaconitine is a photosensitive antiarrhythmic and hypertension drug, whose major photoproduct (N-acetyl anthranilic acid) is also a potent photosensitizer. Both these compounds are lipophilic and might bind efficiently to cell membranes thereby causing phototoxic damage. Photolysis of natural lappaconitine (I) as well as its N(20) des-ethyl derivatives (N-Bz (II), N-Me (III), N-H (IV), and N(O)-Et (V)) results in cleavage of the ester bond with the formation of N-acetyl anthranilic acid (VIII) and corresponding enamine. The lappaconitine derivative V shows maximum photostability which correlates with reference data about its low toxicity. It was shown that the primary reaction step is electron transfer from the amino group to the anthranilic fragment of lappaconitine resulting in an intermediate biradical. The final products are formed via fragmentation of the neutral lappaconitine radicals.
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PMID:CIDNP and EPR study of phototransformation of lappaconitine derivatives in solution. 2023 76


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