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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The whole-body retention of intravenously administered [99mTc]DTPA was measured by urine analysis and whole-body counting in eight normal subjects. On average, the elimination of [99mTc]DTPA was faster in these subjects than in 11 patients under study for hypertension whose whole-body retention data were used in MIRD Dose Estimate Report No. 12. The average residence time for [99mTc]DTPA in total body, less bladder contents, was only 65% of the MIRD value. However, despite this difference, the dosimetry is similar in both cases largely owing to the influence of radioactivity in bladder contents. Approximately 2-3% of the administered radioactivity was retained in the body for a time that was long relative to the physical half-life of 99mTc, and probably reflects a small amount of protein binding of the DTPA preparation.
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PMID:Radiation absorbed dose from technetium-99m DTPA. 310 Jul 35

The effects of surgical renal revascularization on both hypertension and kidney function was assessed in 16 patients with renovascular hypertension (14 unilateral). We have taken a special interest to the split renal function studied with DTPA renogram. The function of the operated kidney was improved in 9 patients and not improved (worsened or unchanged) in 7. Hypertension was cured in 25% and improved in 56% of the patients, without correlation with split renal function outcome.
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PMID:[Evaluation of surgical renal revascularization in renovascular arterial hypertension. Measurement by 99m Tc DTPA scintigraphy]. 314 29

In order to improve on the technique of noninvasive detection of renal artery stenosis, we studied the effects of angiotensin converting enzyme inhibition with captopril on individual kidney hemodynamics and function as assessed by technetium-99m diethylenetriaminepentaacetic acid [( 99mTc]DTPA) renal flow studies and iodine-131 orthoiodohippurate [( 131I]hippuran) renography in experimental Goldblatt's hypertension. In two-kidney, one-clip (renin-dependent) hypertension, captopril (1.5 mg/kg bolus with 1.5 mg/min infusion) reduced mean arterial pressure (MAP) and ipsilateral glomerular filtration rate (GFR) without changes in the contralateral kidney. Captopril infusion resulted in alterations in both the [99mTc]DTPA and [131I]hippuran studies, which were most evident in the 15-min [99mTc]DTPA renal flow studies. In one-kidney, one-clip (volume-dependent) hypertension, captopril reduced MAP but did not alter GFR, renal plasma flow, or the radionuclide studies. These studies suggest that the [99mTc]DTPA renal flow study coupled with captopril challenge may unmask intrarenal angiotensin II-dependent functional and hemodynamic changes of the stenotic kidney, and offers promise in the detection of renin-dependent hypertension.
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PMID:Captopril renography in two kidney and one kidney Goldblatt hypertension in dogs. 329 73

In summary, a natriuresis and diuresis following the relief of BUO is common. This is frequently associated with the reversal of hypertension and other signs of salt and water retention. The need for replacement therapy is best determined from clinical assessment of salt and water status. Only rarely will a prolonged salt-losing state ensue, but the physician must be aware of this possibility, since long-term replacement of water and electrolytes may be required. Recovery of function occurs in two phases, an early tubular phase and a later glomerular phase. The tubular phase appears to be quantitatively more important. There is some disparity between the improvement in creatinine clearance and that in 99mTc DTPA and iohexol clearance, and we would postulate that the initial improvement in creatinine clearance is due to secretion of creatinine during the predominantly tubular phase of recovery. It follows that when assessing renal functional recovery after insertion of a nephrostomy tube or other form of decompression of an obstructed upper urinary tract, these different phases must be borne in mind. Following the relief of UUO, changes in water and electrolyte excretion do occur, but they are rarely of clinical significance.
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PMID:Postobstructive renal function. 331 Jan 74

A nine-year-old child was referred for a routine renal dynamic study to detect a renal and/or renovascular cause for hypertension. Tc-99m DTPA renography accidentally discovered and correctly localized a pheochromocytoma.
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PMID:Serendipity in technetium-99m DTPA renal dynamic study. 354 8

Recent studies have reported that captopril can acutely induce a marked decrease of glomerular filtration rate in kidneys affected by renal artery stenosis, an effect detectable by scintigraphic techniques. Experience which confirms and extends this observation, obtained in five patients with renovascular hypertension, is reported here. For comparison, eight essential hypertensives and six patients with non-vascular unilateral renal diseases were studied. In each patient the ratio of glomerular filtration rate between the two kidneys was estimated during two consecutive scintigraphic studies with the glomerular tracer 99mTc-DTPA: in all renovascular patients captopril induced a marked decrease of glomerular filtration rate on the affected side, whereas negligible changes were observed in all other subjects. These results confirm that captopril may almost completely suppress glomerular filtration in kidneys affected by unilateral renal artery stenosis, an effect which may not be apparent clinically because of compensation by the other kidney, but which is scintigraphically detectable. Renal scintigraphy after captopril is easy to perform and non-invasive. It therefore seems to be a promising tool for the screening of renovascular hypertension.
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PMID:Acute effect of captopril on single kidney glomerular filtration rate in arterial hypertension. 391 Jul 69

Suppression of the renin-angiotensin system (RAS) by angiotensin converting enzyme (ACE) inhibition may induce renal failure in patients with bilateral renal artery stenosis. Recent scintigraphic studies with the glomerular tracer technetium-99m-diethylenetriaminepenta-acetate (99m-Tc DTPA) indicate that in patients with unilateral renal artery stenosis, glomerular filtration rate (GFR) may be markedly reduced in the affected kidney after inhibition of ACE. This finding reflects the important role of the RAS in maintaining GFR (by increasing postglomerular resistance) in states of low renal perfusion pressure. Preliminary observations suggest that this scintigraphic test might be useful in the detection of renovascular hypertension.
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PMID:Kidney scintigraphy after ACE inhibition in the diagnosis of renovascular hypertension. 391 23

A case of neonatal adrenal hemorrhage associated with transient obstruction of the kidney and hypertension is reported. Sonography demonstrated a mass in the right suprarenal area, consistent with hemorrhage into the adrenal gland. DTPA renal scan showed prolonged retention of the injected material in the right kidney, consistent with obstructed outflow from the renal collecting system. Gradual decrease in the size of the suprarenal mass was associated with relief of the renal obstruction as evidenced by a normal repeat renal scan, and a return to normal of the blood pressure. It appears that the cause for the hypertension was the acute renal obstruction, which was due to either direct pressure on the proximal ureter by a large adrenal mass or secondary to displacement of the kidney by the mass resulting in kinking of the proximal ureter.
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PMID:Transient obstruction of the kidney and hypertension due to neonatal adrenal hemorrhage. Case report. 391 65

One hundred forty-nine standardized K/A rations (renal bolus ascending slope: aortic bolus ascending slope) were performed on 33 post-transplant patients with acute or chronic rejection, obstruction, acute tubular necrosis, infection or acute hypertension after rapid intravenous injection of Tc-99m DTPA. The correlation of creatinine clearance versus the K/A ratio for 123 pairs of data performed on the same day was poor (r = 0.37), but the correlation was greatly improved (r = 0.72) when K/A ratio maxima or minima were compared with corresponding creatinine clearances performed during a nonrejection period, or acute rejection episode, respectively. Seventeen acute rejection episodes resulted in a 20% or greater decrease in the K/A ratio 16 times, but were observed as a change in the serial perfusion phase scintiphotos only five times, or in the function phase scintiphotos only six times. Of 27 significant decreases in K/A ratios, 22 were due to acute rejection, two to obstruction, one to infection, one to acute hypertension, and one was unexplained. Thus the K/A ratio is a sensitive but not specific index for following pathological changes in the renal allograft.
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PMID:Application of the kidney to aortic blood flow index to renal transplants. 635 51

To evaluate the clinical validity of 99m Tc DTPA renal investigation, we have studied 60 patients with different renal diseases: 1) Renovascular hypertension (22 patients); 2) Chronic pyelonephritis (11 patients); 3) Renal hypoplasia (12 patients); 4) Bilateral parenchymatous nephropathy with hypertension (15 patients). We observed a good correlation between the creatinine clearance and the total DTPA clearance (N = 51: r = 0.68; p less than 0.001); and also a good correlation between the respective renal surface extrapolated from renal X-Rays, and the respective renal function of each kidney (expressed in percentage) measured from DTPA data. This correlation is higher in group 1 and lower in group 2. From individual kidney function percentage and glomerular filtration rate measurement or estimation, we could calculate the GFR of each kidney, which serves as a guideline for surgical decisions.
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PMID:[Comparative evaluation of the function of each kidney using Tc 99m DTPA]. 637 85


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