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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The morbidity and mortality due to cardiovascular complications of chronic arterial hypertension are distinctly reduced by persistent and successful antihypertensive therapy. The principal emphasis is on drug therapy. Diet and psychotherapy should be used as supportive measures. Examples of antihypertensive drugs available for general practice: saluretics, beta-receptor blockers, dihydralazine (Nepresol), alpha-methyldopa, clonidine (Catapresan), reserpine and guanethidine (Ismelin). With mild hypertension (diastolic blood pressure up to 105 mm Hq), monotherapy with a beta-receptor blocker or a saluretic is indicated first. Contrary to the medical rule never to use a combination preparation if it can possibly be avoided fixed combinations have proved valuable in hypertensive therapy and facilitate therapy for the hypertensive patient and for the doctor.
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PMID:[Therapy of hypertension in general practice. Comments on the recommendations of the German Antihypertension League (author's transl)]. 30 37

Guanethidine sulfate, a potent antihypertensive agent with a prolonged duration of action, was given in large oral doses to eight hypertensive patients in a loading technique. Blood pressure control resulted within one to three days without side effects, with total loading doses varying from 125 to 650 mg. Based on the drug's pharmacokinetic properties, a maintenance dose required to sustain the desired antihypertensive effects was calculated from the loading dose for each individual. Blood pressure was satisfactorily controlled in the seven patients followed for at least 12 months, and no modification of the calculated guanethidine dose was required. Side effects were minimal and well tolerated. The ease of initial blood pressure regulation with this regimen and the precision with which a maintenance dose can be determined suggest that guanethidine deserves a more prominent role in the therapy of established hypertension.
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PMID:Guanethidine in antihypertensive therapy: experience with an oral loading regimen. 110 67

1. The antihypertensive effect and side-effects of the new centrally acting agent guanfacine (BS 100-141, Estulic) and guanethidine (Ismelin) were compared in a single-blind, cross-over study. The study consisted of two active treatment periods of 6 weeks each, both preceded by a 1-3 weeks placebo period. 2. Sixteen ambulant patients (six male, ten female) with mild or moderate hypertension were admitted to the study. The patients were also receiving diuretic therapy (clopamide 10-20 mg daily). On average the optimal daily dose of guanfacine was 3 mg and of guanethidine 20 mg. 3. An equally large and significant decrease in blood pressure was produced by both drugs. Both guanfacine and guanethidine caused a very slight reduction in heart rate. Mild orthostatic hypotension occurred in 11 patients during guanethidine therapy. Dryness of the mouth occurred in 13 patients taking guanfacine.
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PMID:Comparative study of two antihypertensive agents: guanfacine and guanethidine. 699 86