Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020538 (
hypertension
)
170,190
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Eight compounds were obtained from the dry fruits of
Piper longum
L., and their potential vascular relaxant activities were explored. The present study first revealed the access of Rosin (
7
) and Piperchabaoside (
8
) in the medicinal plant
Piper longum
L. The vessel tension studies showed that Piperine (
2
), (2E,4E,14Z)-N-isobutyleicosa-2,4,14-trienamide (
3
), and
Piperlonguminine
(
6
) exerted significant inhibitory effects on PE-induced mesenteric artery vasoconstriction. Furthermore, Calcium Imaging studies were applied to observe the effect of Piperine on the intracellular calcium in mesenteric artery smooth muscle cells (MASMCs). Piperine (
2
) was observed to promote the influx of extracellular calcium in MASMCs, and via an endothelium-independent mechanism involving Ca
2+
entry.
Piper longum
L. might have a great potential to be further studied as a vascular relaxant, even to be a drug candidate of anti-
hypertension
.
...
PMID:Chemical constituents from the fruits of
Piper longum
L. and their vascular relaxation effect on rat mesenteric arteries. 3274 9
