Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In view of the statistically significant falls in blood pressure achieved at the end of two weeks only, it would seem that methyclothiazide is an effective antihypertensive agent, at least in the new cases of mild hypertension treated in this trial. The results are, perhaps, particularly impressive in view of the fact that the majority of patients were treated with the smaller dose of 5mg daily. In this trial, postural hypotension was of no importance whatsoever, and the incidence of side effects was minimal. Methyclothiazide would seem to be a suitable choice for the treatment of mild hypertension in general practice.
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PMID:Methyclothiazide in hypertension. A report from the General Practitioner Research Group. 68 38

Methyclothiazide added for 7 weeks to the drinking water of weanling Dahl rats attenuated development of hypertension in salt-sensitive (DS) rats, but did not affect blood pressure in salt-resistant (DR) ones. There were no appreciable effects on heart rate, body weight, or sympathetic nerve activity. Cardiovascular responses to electrical stimulation of the ventromedial hypothalamus, or to intravenous injections of norepinephrine, tyramine, or vasopressin, were likewise unaffected. These results indicate that the antihypertensive effect of methyclothiazide in DS rats does not depend on sympathetic inhibition.
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PMID:Methyclothiazide attenuates salt-induced hypertension without affecting sympathetic responsiveness in Dahl rats. 619 Nov 35