Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To evaluate the advantage of free fatty acid imaging on the detection of hypertrophied myocardium, we compared sequentially myocardial thallium and BMIPP (15-(p-iodophenyl)-3-(R,S)-methyl pentadecanoic acid) distribution in spontaneously hypertensive rat (SHR) using dual tracer autoradiography and in vivo pin-hole imaging. Autoradiography and pin-hole imaging showed uniform myocardial distribution of BMIPP and thallium within less than 27 weeks age SHR. In 40 weeks age SHR, thallium myocardial distribution showed uniform, however, BMIPP had focal decreases. Quantitative analysis of pin-hole images showed that myocardial BMIPP and thallium uptake ratio decreased according to the ages of SHR. Our data suggest that hypertension is associated with uniform myocardial perfusion and focal alternation in the substrate used for the performance of myocardial work. Based on the above autoradiographic and in vivo pin-hole imagings, I-123 BMIPP imaging may have a potential for early detection on hypertrophic myocardium compared to thallium perfusion in clinically hypertensive patients.
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PMID:[Serial assessment of myocardial thallium perfusion and fatty acid utilization in spontaneously hypertensive rats: assessment by autoradiography and pin-hole imaging]. 281 Sep 4

Although, the diagnosis of idiopathic cardiomyopathy is determined by cardiac catheterization including myocardial biopsy, non-invasive diagnosis is important. The most useful method is nuclear cardiology to differentiate dilated cardiomyopathy from ischemic cardiomyopathy. Cardiac images in ischemic cardiomyopathy have wider perfusion and metabolic defects than in dilated cardiomyopathy using Tl-201, Tc-99m perfusion tracers, I-123 BMIPP, N-13 NH3 and F-18 FDG. The degree of heterogenecity of the myocardium is higher in ischemic cardiomyopathy than in dilated cardiomyopathy by these tracers. Left ventricular hypertrophy is common finding in hypertension and hypertrophic cardiomyopathy. However, in hypertensive heart disease the left ventricular wall thickness rarely exceed than 20 mm, and the septal wall thickness/posterior wall thickness is not more than 1.5, which are frequently shown in hypertrophic cardiomyopathy. Right ventricular hypertrophy near the ventricular septum is also one of the characteristic findings in hypertrophic cardiomyopathy.
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PMID:[Differential diagnosis of idiopathic cardiomyopathy from ischemic cardiomyopathy and hypertensive heart disease using non-invasive methods]. 1088 17