Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020538 (
hypertension
)
170,190
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The gasotransmitter hydrogen sulfide (H
2
S) is involved in the regulation of the vascular tone and an impairment of its endogenous production may play a role in
hypertension
. Thus, the administration of exogenous H
2
S may be a possible novel and effective strategy to control blood pressure. Some natural and synthetic sulfur compounds are suitable H
2
S-donors, exhibiting long-lasting H
2
S release; however, novel H
2
S-releasing agents are needed to improve the pharmacological armamentarium for the treatment of cardiovascular diseases. For this purpose, N-phenylthiourea (PTU) and
N,N'-diphenylthiourea
(DPTU) compounds have been investigated as potential H
2
S-donors. The thioureas showed long-lasting H
2
S donation in cell free environment and in human aortic smooth muscle cells (HASMCs). In HASMCs, DPTU caused membrane hyperpolarization, mediated by activation of K
ATP
and Kv7 potassium channels. The thiourea derivatives promoted vasodilation in rat aortic rings, which was abolished by K
ATP
and Kv7 blockers. The vasorelaxing effects were also observed in angiotensin II-constricted coronary vessels. In conclusion, thiourea represents an original H
2
S-donor functional group, which releases H
2
S with slow and long lasting kinetic, and promotes typical H
2
S-mediated vascular effects. Such a moiety will be extremely useful for developing original cardiovascular drugs and new chemical tools for investigating the pharmacological roles of H
2
S.
...
PMID:Searching for novel hydrogen sulfide donors: The vascular effects of two thiourea derivatives. 3256 13
