Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of psychosocial stress produced by aggregation in a special cage designed by Henry was investigated in three separate experiments using Wistar-Kyoto (WKY), Sprague-Dawley (SD) and F1 hybrids of the Japanese spontaneously hypertensive and Wistar-Kyoto (SHR-WKY F1) rats. Each aggregated group displayed typical 'stressed' behavioural disturbances. Adrenal hypertrophy, elevation of plasma renin activity and gastric erosions were noted in male aggregated SD rats; while adrenal enlargement, elevation of plasma noradrenaline and gastric erosions were found in male aggregated SHR-WKY F1 rats. Sustained hypertension, however, did not develop in any strain nor in any subgroup within each strain. Gastric erosions were also noted in isolated SD and SHR-SKY F1 rats suggesting that long term isolation of rats also induces stress. Isolated rats also remained normotensive throughout. Reduced haematocrit was found in both aggregated and isolated male SHR-WKY F1 rats suggesting increased plasma volume. We conclude that neither stress due to psychosocial disturbances nor that due to isolation produces chronic hypertension in the three strains of rat studied.
 ...
PMID:Failure of psychosocial stress to induce chronic hypertension in the rat. 654 22

With enzyme linked immunosorbent assays, using a solid phase Clq method, we determined free circulating immunocomplexes (CIC) in the serum of 47 pregnant women. In 30 normal pregnant women without EPH gestosis no CIC could be found. 3 normal pregnant women showed temporary CIC after viral infections. In 7 women with slight gestosis no traceable CIC concentrations were present. All 7 patients with medium or severe gestosis had clearly positive CIC levels simultaneous with hypertension and during the further course of the pregnancy. Hospitalisation and antihypertensive therapy had to be carried out because of increasing symptoms of gestosis. Thus only in medium and severe gestoses clearly demonstrable CIC concentrations could be measured. The presence of free circulating CIC might be a prognostically unfavourable indication for the further course of an EPH gestosis.
 ...
PMID:[Detection and clinical significance of free circulating IgG immune complexes in EPH (edema, proteinuria, hypertension) gestosis]. 655 Dec 97

Edema proteinuria hypertension gestosis represents a disease syndrome that is defined by its occurrence in association with pregnancy and by its patient population. Although the difference between true and superimposed EPH-gestosis remains poorly defined clinically, a clearer definition seems feasible if epidemiological data, which have been developed in long-term follow-up studies, are utilized. These circumstances permit the identification of a well-defined, young, primiparous population that is afflicted during pregnancy with a disease syndrome of unknown etiology. Among many suggested theories, the immunologic concept of EPH-gestosis has attracted increasing attention over the recent past. Assuming an immunologic etiology for this disease syndrome, EPH-gestosis is understood to represent a partial or total malfunction or maladaptation of the immune system of the mother and/or the fetus. According to this concept, EPH-gestosis is considered to represent partial rejection of the fetal allograft. In the present review evidence for an immunologic etiology of EPH-gestosis has been summarized. It may be concluded that, in spite of a large body of available information, no definitive proof for an immunologic etiology of EPH-gestosis has yet been presented. Only the further clarification of the immunologic processes involved in the tolerance of normal pregnancy will allow the detection in those mechanisms of abnormalities associated with EPH-gestosis. Until then, EPH-gestosis will remain a condition of unknown etiology. The immunologic concept, similar to other concepts, needs further clarification until the "concept" can become an etiology.
 ...
PMID:The immunologic concept of EPH-gestosis. 703 92

Two behaviorally-oriented, nonpharmacological treatments - rational-emotive therapy/assertiveness training (RET/AT) and anxiety management training (AMT) - and one control treatment - hypertension education counseling (HEC) - were compared in reducing blood pressures of 22 white-collar mold hypertensives in a worksite setting. Results showed significant reductions by posttreatment in diastolic pressures of participants in the two behavioral treatment conditions, but no significant differential treatment effect across groups. Systolic pressure reductions by postreatment were significant only in the RET/AT training condition. Reductions were generally maintained at an either-week follow-up.
 ...
PMID:Worksite-based behavioral treatment of mild hypertension. 711 11

Retrospective evaluation was applied to 162 pregnancies of women with hypertension at the Third Municipal Hospital of Sofia, Department of Obstetrics and Gynaecology, for a period between 1976 and 1980. The birth record in that period amounted to 9348. Hypertension was recorded from 1.7 per cent of the deliveries. All women examined were primiparae. They were subdivided by four groups: essential hypertension, organic hypertension, EPH gestosis, and plug gestosis. Sixty-two patients with an earlier record of EPH gestosis were additionally examined in a follow-up programme, between 1977 and 1980. Most of the hypertension cases were identified as having been different from EPH gestosis. An attempt is made to group hypertension during pregnancy. The authors suggest that higher accuracy of diagnosis will help to reduce the incidence of both essential hypertension and EPH gestosis. An analysis was made of diagnostic and therapeutic approaches, control of labour, and condition of the newborns.
 ...
PMID:[Hypertension, pregnancy and childbirth]. 716 56

Gestosis index score at delivery was compared with factors reflecting the fetal development in a series of 95 patients with EPH-gestosis collected in Okayama University Medical School in 1975-1979. The prediction of small for date (SFD) was performed by means of multivariate analysis of 10 variables, i.e. gestosis index, maternal body weight, height, uterine fundal length, abdominal circumference, maternal age at delivery and urinary estriol within one week prior to delivery. The result was that gestosis index was as useful as uterine fundal length in predicting SFD. The more gestosis index score increased, the more markedly the fetal development ws disturbed. Especially in the cases with scoring above 4 and in those with hypertension and proteinuria, the incidence of SFD increased obviously. No correlation between gestosis index and neonatal asphyxia was noticed. From the growth pattern of uterine fundal length and BPD, intrauterine growth retardation (IUGR) in pregnancy with EPH-gestosis occurred mainly within the third trimester of pregnancy. The functional development of the fetus with EPH-gestosis was evaluated with the use of urinary estriol level and fetal heart rate (FHR) monitoring. In the cases with EPH-gestosis scoring above 4, extreme disturbance of functional development of the fetus was observed.
 ...
PMID:Estimation of gestosis of pregnancy (EPH-gestosis), relationship between fetal development and gestosis index. 719 59

Hyperoncotic hemodilution is proposed as a new therapeutic procedure in EPH-gestosis for improvement of uterine blood flow. By infusion of human albumin solutions in acute experiments on pregnant Merino sheep the effects of altered maternofetal colloid osmotic pressure gradients were investigated. The proposed hemodilution treatment improved uterine blood flow without a theoretically apprehended and undesired fetal hemoconcentration. An absolute indication for hypervolemic EPH-gestosis is suggested in accordance with modern knowledge of the pathophysiology of microcirculation. Isovolemic hemodilution is proposed to be of potential value in cases of EPH-gestosis with normovolemia, hypertension, intrauterine fetal growth retardation or other symptoms of placental insufficiency, at least as a subject to further studies.
 ...
PMID:[Hyperoncotic hemodilution in the ewe asa model of therapy in EPH gestosis (author's transl)]. 719 53

Five cases of pregnant woman with symptoms of right upper quadrant pain, hemoconcentration, liver dysfunction, and thrombocytopenia are presented as representative of impending gestosis. Plasma volume expansion achieved by either bed rest or intravenous albumin administration appeared to be effective therapy. It is presumed that impending gestosis represents an early form of severe toxemia (edema/proteinuria/hypertension [EPH[ gestosis).
 ...
PMID:Impending gestosis. 731 42

Of 27.978 newborns delivered at the University Hospital Department of Gynecology and Obstetrics in Beogradu, from 1978 to 1980, 2218 (7.92%) were born by cesarean sections. Clinical-biochemical and morphological elements of hypoxic and ischemic CNS lesions were found in 107 (4.82%) cases out of the infants born by cesarean section and in 1301 (5.05%) cases out of the infants born by vaginal delivery. The difference is not statistically significant. Investigations of the causes, i. e. risk factors of CNS lesions in infants born by cesarean section, in correlation with the control group consisting of 670 cesarean sections performed in 1980 without CNS lesions, have revealed: a) high risk factor (p less than 0.01) appeared to involve parity (para III and more), maternal diseases (hypertension, diabetes mellitus, EPH gestosis), placenta praevia, premature rupture of the membranes, prematurity birth weight below 2500 g, and low Apgar score (1-7); b) significant risk factors (p less than 0.05) are some social factors (unemployed mothers and mothers from rural areas), duration of labor (more than 10 hours), transverse presentation, hydramnion, previous spontaneous abortions and stillbirths. The analysis has shown that CNS lesions in infants born by cesarean section may result from different factors; medical, biological, and social.
 ...
PMID:[Analysis of causes of CNS damages in neonates delivered by cesarean section (author's transl)]. 734 21

Forty-eight patients hospitalised for EPH gestosis were treated for hypertension, using one constant dosage of Dilatol tablets. Blood pressure dropped at the beginning of the therapy, but it re-increased in the course of further treatment. Hypotensors had to be administered additionally to 22 patients.
 ...
PMID:[Effects of nylidrine (Dilatol) on blood pressure of hypertensive patients in advanced pregnancy (author's transl)]. 746 61


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>