Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020538 (
hypertension
)
170,190
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The identity of the specific
nitric oxide dioxygenase
(
NOD
) that serves as the main in vivo regulator of O
2
-dependent NO degradation in smooth muscle remains elusive. Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth muscle cells with unknown function. Cygb, coupled with a cellular reducing system, efficiently regulates the rate of NO consumption by metabolizing NO in an O
2
-dependent manner with decreased NO consumption in physiological hypoxia. Here we show that Cygb is a major regulator of NO degradation and cardiovascular tone. Knockout of Cygb greatly prolongs NO decay, increases vascular relaxation, and lowers blood pressure and systemic vascular resistance. We further demonstrate that downregulation of Cygb prevents angiotensin-mediated
hypertension
. Thus, Cygb has a critical role in the regulation of vascular tone and disease. We suggest that modulation of the expression and
NOD
activity of Cygb represents a strategy for the treatment of cardiovascular disease.
...
PMID:Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall. 2839 74
