Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors examined dynamicaly from the third day to the third month the activity of enzymes, participating in glycolysis (ALD, PK, LDH), pentosemonophosphate shunt (G6P-DH), citric cycle (MDH, INDH) in the myocardium of rats with hypertension, induced by the method of Selye, modified by Kolarova. There were phase changes in enzymatic activity in the myocardium, manifested at the first stages by lowering (LDH, ALD, INDH) or elevation (MDH, PK, G6-DH). The activity of all examined enzymes was over that of the control group on the thirteenth day, while there were also oscillations on the nineteenth day. Only the actimity of G6-DH revealed a progressive elevation during the whole experimental period. The changes in the enzymic activity of the myocardium at the first stages were interpreted as a sign of nonspecific adaptation to the changed conditions of heart activity. The later changes were manifestations of the disturbances at various metabolic links, which were unevenly involved in the processes of myocardial hypertrophy.
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PMID:[Changes in myocardial activity of several enzymes of glycolysis, the tricarboxylic acid cycle and pentosephosphate shunt in rats with experimental hypertension]. 101 10

The study was carried out on rats of the Wistar strain with experiments hypertension by the method of Selye, modified by Kolarova. These authors examined the activity of the enzymes of protein metabolism (GOT, GPT, AP), of glycolysis (ALD, LDH, alpha-HBDH) and of the citric cycle (MDH) in the left and right kidney at various intervals after modeling the process (3th, 15th, 30th and 90th day). The activity of the enzymes of the glycolytic chain and the cycle of Krebs in the left kidney was lowered at all stages of the experiment. Transaminase activity diminished progressively. Such a dynamics revealed the activity of adenosine phosphate as well. The activity of all examined enzymes of the right kidney showed phase changes-after initial elevation on the third day there was a lowering at the later stages of the experiment. The altered activity off the left kidney was connected with the disturbed vascularization with subsequent metabolic changes. The changes in the enzymic activity in the right kidney were assumed as a consequence of the occurred adaptive hyperfunction.
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PMID:[Changes in renal enzyme activity in rats with experimental hypertension]. 102 9